I gave in! After students asking for it, I now made a simple figure design checklist. To help all scientists w/o graphic skills create clear, accessible, and truthful charts! -> Out in @nature Cell Biology: rdcu.be/erwl4 #DataVisualization #PhD #SciComm Thx for review @bethcimini.bsky.social + 2

A checklist for designing and improving the visualization of scientific data

Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...

rdcu.be

Here are some of the best entries in NPR's 2024 College Podcast Challenge.

Announcing the 2024 NPR College Podcast Challenge Honorable Mentions

Here are some of the best entries in NPR's 2024 College Podcast Challenge.

n.pr

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: @cellpress.bsky.social www.cell.com/cell/fulltex...

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

cell.com

Peripheral infection wires T cells in the brain www.nature.com/articles/s41...

I’m thrilled to share our work out now in Nature identifying CREM as a central intracellular checkpoin in #CARNK cells. 📄Link: nature.com/articles/s41... Our story👇🏼

CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells - Nature

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeri...

nature.com

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease

In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloi...

cell.com

🚀 Excited to release BoltzDesign1! ✨ Now with LogMD-based trajectory visualization. 🔗 Demo: rcsb.ai/ff9c2b1ee8 Feedback & collabs welcome! 🙌 🔗: GitHub: github.com/yehlincho/Bo... 🔗: Colab: colab.research.google.com/github/yehli... @sokrypton.org @martinpacesa.bsky.social

A study published in Genome Medicine provides a framework to support the integration of a single untargeted proteomics test into routine diagnostic practice for the diagnosis of mitochondrial and potentially other rare genetic disorders. bit.ly/4dKQ48e #Epigenetics #MedSky

In #Science #Immunology, researchers at @stanfordmedicine.bsky.social studied #IFNs in human #fetal #thymus development. They found type I & II IFNs play distinct but critical roles in cortical & medullary thymic #EpithelialCell differentiation!

Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development

Single-cell transcriptomics identifies type I and II interferons as regulators of cortical and medullary thymic epithelial differentiation.

science.org

These beautiful pins came in! 🙌🏾 they’re gifts for our MINDS post-bacc scholars who will be starting grad school in the fall ❤️🎉 • • Always love supporting women-owned, people-of-color-owned businesses ✨ but I especially love supporting my friends @christineliu.art 😍 twophotonart.com

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature

Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

nature.com

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/cor... Paper link below 👇

JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...

Online now: Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses

Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses

T helper (Th) 2 cells and group 2 innate lymphoid cells (ILC2s) express similar effector molecules in response to distinct signals—TCR engagement and interleukin-33, respectively. Guichard et al. find that NF-κB is essential for type 2 cytokine production in ILC2s but dispensable in Th2 cells, with pre-existing chromatin accessibility dictating NF-κB recruitment and shaping cell-type-specific transcriptional programs.

dlvr.it

#GliaPapers #GliaMay2025 MAY COVER Carl Weigert, Mihály (von) Lenhossék, Gustav Retzius, and Hans Held surround hand drawn images of glia from the late 1800 and early 1900s. (see Kettenmann et al, onlinelibrary.wiley.com/doi/10.1002/...)

T cell-specific antigens are discovered at high throughput without killing target cells go.nature.com/3L6cuDp rdcu.be/ekKtU

High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits - Nature Biotechnology

T cell-specific antigens are discovered at high throughput without killing target cells.

go.nature.com

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...

Redefining CNS immune privilege - Nature Reviews Immunology

In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

nature.com

My mom used to love #FluorescenceFriday, so I will keep posting in her memory ❤️ This photo shows neurons in the hippocampus accumulating phospho-tau in our monkey model of Alzheimer's Disease. Markers: Dapi 🔵, Neun 🔴, pTau 422🟣, AT8🟡

Together with leading science organizations, ASM filed an amicus brief calling for immediate restoration of NIH grants supporting early-career scientists. Read the press release: asm.org/press-releas...

I’m excited to be speaking at #IMMUNOLOGY2025™ on May 7 during the Lymphatic Immunophysiology Major Symposium! Join us to discuss the meningeal lymphatic system and its impact on brain immunity and function. #immunology #neuroimmunology Register today! immunology2025.aai.org/register/ #AAI2025

Register - IMMUNOLOGY2025™

Join or renew your AAI membership for 2025 to immediately be eligible for discounted IMMUNOLOGY2025™ registration fees.

immunology2025.aai.org

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Inflammasome signaling in astrocytes modulates hippocampal plasticity

The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

cell.com

It was so great for my lab to be able to contribute to this awesome study led by @fchrisbennett.bsky.social @nachoriko.bsky.social @waisenberg.bsky.social.

Immunity@cp-immunity.bsky.social · last yr.

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace. Congrats to first author Jonathan Bastos!

Immunity@cp-immunity.bsky.social · last yr.

Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia

Open call for Next Generation Leaders! Our NGL program recognizes early career scientists with fresh and innovative perspectives. For 3 years, NGLs contribute to ongoing research and initiatives at the Allen Institute. Apply by June 3. alleninstitute.org/about/people...

Next Generation Leaders

The Next Generation Leaders program at the Allen Institute aims to support emerging and diverse early-career researchers in bioscience who will contribute to cultivating new ideas to make a broad, tra...

alleninstitute.org

New NYT Article on the first 100 days in Charts www.nytimes.com/interactive/... Deeply concerning in many regards... Sadly (although it is good for folks to understand), NIH funding slowdown made the cut... 1/2

Trump’s Astonishing 100 Days, in 8 Charts (Gift Article)

By many measures, the opening months of President Trump’s second term stand apart from those of essentially any modern president.

nytimes.com

Mammalian cells eliminate nascent chains stalled during co-translational protein translocation by activating a ribosome UFMylation-dependent TAQC process at the ER. Ennis, Wang, Ye et al. establish a role for NEMF-mediated CAT tailing in TAQC. rupress.org/jcb/article/... #ER_literature

Our latest work now online in Cell: Rewriting regulatory DNA to dissect and reprogram gene expression Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression Thread 👇

Michael Montgomery@michaeltmont.bsky.social · last yr.

I am elated to share that our manuscript describing Variant-EFFECTS, a high-throughput technology we developed to precisely and quantitatively measure the effects of CRISPR-mediated edits on gene expression, is now published at @cellpress.bsky.social: authors.elsevier.com/c/1kxgiL7PXu...

Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics. doi.org/10.1038/s420...

Real time characterization of the MAPK pathway using native mass spectrometry - Communications Biology

Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.

doi.org

At Princeton University we are being clear about our continued commitment to diversity and nondiscrimination, in full compliance with law (as opposed to executive order) and consistent with our ethical responsibilities as educators for the entire nation. www.dailyprincetonian.com/article/2025...

University websites updated to reflect commitments to diversity, non-discrimination

Many University websites, including those affiliated with admissions, academic departments, and diversity, equity, and inclusion (DEI) initiatives, have been updated to reflect Princeton’s ongoing com...

dailyprincetonian.com

Explore top neuroscience meetings and events. Filter events by topic, and see upcoming webinars compiled by @worldwideneuro.bsky.social. Are you organizing a neuroscience conference? Share it with us at community@thetransmitter.org #neuroskyence www.thetransmitter.org/events/?utm_...

Events

thetransmitter.org