🚨 New preprint alert!! 🧠🦟🦠 What does West Nile virus actually do to a human neuron? We built an hiPSC-neuron platform, mapped WNV infection by temporal proteomics + RNA-seq, and found LA24, a new strain that is attenuated in neurons. 📄 www.biorxiv.org/content/10.6... 🧵👇

Human iPSC-derived neurons identify West Nile virus neuropathogenesis signatures and reveal strain-dependent neuroattenuation

West Nile virus (WNV) is one of the leading causes of arthropod-transmitted encephalitis in the world, yet its effects on neurons, the principal target of WNV in the brain, remain poorly defined. Here...

biorxiv.org

Human iPSC-derived neurons identify West Nile virus neuropathogenesis signatures and reveal strain-dependent neuroattenuation https://www.biorxiv.org/content/10.64898/2026.09.23.753976v1

🚨 New preprint alert!! 🧠🦟🦠 What does West Nile virus actually do to a human neuron? We built an hiPSC-neuron platform, mapped WNV infection by temporal proteomics + RNA-seq, and found LA24, a new strain that is attenuated in neurons. 📄 www.biorxiv.org/content/10.6... 🧵👇

Human iPSC-derived neurons identify West Nile virus neuropathogenesis signatures and reveal strain-dependent neuroattenuation

West Nile virus (WNV) is one of the leading causes of arthropod-transmitted encephalitis in the world, yet its effects on neurons, the principal target of WNV in the brain, remain poorly defined. Here...

biorxiv.org

Watch the full #ECDCOnAir episode for more on dengue, chikungunya, West Nile virus and Europe’s changing mosquito landscape on: 🎧 Spotify: bit.ly/ECDConAir77 📺 YouTube: youtu.be/PCSg7UjHdoY 🎶 Soundcloud: soundcloud.com/ecdc_eu/ecdc... more on #WorldMosquitoDay: www.ecdc.europa.eu/en/news-even...

World Mosquito Day 2026: Europe must upgrade control tools as disease risks rise

Europe needs to improve its preparedness and control efforts as the risk of mosquito-borne diseases increases, with West Nile virus (WNV) continuing to spread to new regions and invasive mosquito spec...

ecdc.europa.eu

West Nile virus activity is at a five-year high in California. CDPH urges Californians to take steps to protect against mosquito bites as hot temperatures contribute to more mosquitoes and increased risk of transmission. Learn more: www.cdph.ca.gov/Programs/OPA... [1/4]

How worried should you be about West Nile virus? Berkeley public health professor Dr. Justin Remais discusses how to protect yourself from this mosquito-borne disease, as he notes another sharp rise in California’s West Nile virus activity. bit.ly/4cn0JpV

How worried should you be about West Nile virus?

Dr. Justin Remais of the UC Berkeley School of Public Health on how to protect yourself from this mosquito-borne disease.

bit.ly

First WNV death in Spain this year: efe.com/andalucia/20... #WestNileVirus

Confirman la muerte en Sevilla de un hombre de 82 años por virus del Nilo - EFE

La Consejería de Presidencia, Sanidad y Emergencias de la Junta confirma la muerte en Sevilla de un hombre de 82 años por virus del Nilo.

efe.com

Very high WNV activity this year in California 🦟 Take care out there! ...and report dead birds here: westnile.ca.gov

Mosquito-borne diseases are breaking records as climate change and other human influences allow the insects to expand their range go.nature.com/4x6xhMK

How mosquitoes are conquering the world — in four charts

Mosquito-borne diseases are breaking records as climate change and other human influences allow the insects to expand their range.

go.nature.com

Excited to share our new review! 🎉 Together with @rhuttenhain.bsky.social, we discuss how emerging proteomics approaches are revealing the spatial and temporal organization of the cellular proteome. Great fun writing this together! www.sciencedirect.com/science/arti...

Resolving cellular signaling in space and time: From organelle proteomics to spatial phosphoproteomics

Cellular signaling is inherently organized in space and time, requiring coordinated control of protein localization, molecular interactions, and enzym…

sciencedirect.com

Ruth Huttenhain@rhuttenhain.bsky.social · 3mo ago

Excited to share our new review in Current Opinion in Chemical Biology! We discuss how advances in proteomics are transforming our understanding of where, when, and how signaling occurs in cells. Thanks to @alexmatia.bsky.social for writing the article with me. www.sciencedirect.com/science/arti...

Preprint out! We optimized synchro-PASEF for phosphoproteomics & found equivalent biological insights to dia-PASEF despite fewer total IDs. Practical tip: apply retention time summation factor 2 to any PASEF phosphoproteomics data—you'll gain IDs and precision. www.biorxiv.org/content/10.6...

Systematic optimization and benchmarking of synchro-PASEF for high-throughput phosphoproteome profiling

High-throughput data-independent acquisition (DIA) workflows paired with short chromatographic separations are increasingly adopted for systems biology and clinical proteomics. However, narrower peak ...

biorxiv.org

V-SWITCH: A single-vector OFF-to-ON fluorescent reporter of live RNA virus infections https://www.biorxiv.org/content/10.64898/2026.04.08.717260v1

Not the best way to start a Thursday in the Bay Area

Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social

Could targeting viruses be a new hope against neurodegenerative diseases?

Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…

plos.io

Not all West Nile virus lineages behave alike: vector competence and minimum infectious dose differences between lineages 1 and 2 https://www.biorxiv.org/content/10.64898/2026.02.03.700853v1

NEW PAPER OUT! Pathogenicity assessment of Spanish West Nile virus isolates of lineages 1 and 2 in a Swiss mouse model doi.org/10.1016/j.ve...

Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...

Austria, Spain, and several other countries just lost their measles elimination status too.

📢 Abstract submission is now open for ViBioM 2026 in Vilnius!! Share your work and be part of the conference in May! #virology #bioinformatics #ViBioM2026 🎤 Talk Abstract Deadline: 6 March 2026 📜 Poster Title Deadline: 17 April 2026 🔗 evbc.uni-jena.de/events/vibio...

Sadly, another country is losing its measles elimination status for a virus whose vaccine is highly effective. www.bbc.com/news/article...

UK loses measles elimination status

Decision made after outbreaks in 2024, when there were nearly 3,000 cases in England and Wales.

bbc.com

Weekly respiratory viruses update: - #influenza circulation HIGH, but has peaked - #RSV circulation ELEVATED and increasing and increasing - #SARSCoV2 circulation remains at LOW levels. More info: erviss.org #ERVISS #RespiratoryViruses #IDsky #EpiSky #COVID19

Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾 www.biorxiv.org/content/10.1...

Global Landscape of Human Kinase Motifs in Viral Proteomes

Viruses are classically viewed as targets of host sensing, yet whether they also sense and respond to host cues remains largely unexplored. We propose that host-driven post-translational modification ...

biorxiv.org

The subclade K of influenza virus is currently 80% of the H3N2 circulating worldwide nextstrain.org/seasonal-flu...

West Nile death reported in California The death, in a county where high numbers of West Nile virus-positive mosquitoes and dead birds have been found, is the fifth West Nile-related death in the state this year.

West Nile death reported in California

It's the fifth West Nile virus-related death in the state this year.

cidrap.umn.edu

Europe's record mosquito-borne disease activity could signal new normal Rising temperatures, longer summers, milder winters, and changing rainfall patterns are creating more favorable conditions for mosquito populations. www.cidrap.umn.edu/c... Photo: Judy Gallagher/Flickr cc

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫 We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

🚨 Out now! Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff #MicroSky 🦠 #NorthwesternUniversity #FeinbergSchoolofMedicine www.nature.com/articles/s41...

Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff - Nature Microbiology

During poxvirus-induced shutoff, certain cellular and viral mRNAs continue to be translated through distinct modes of non-canonical initiation, in part due to altered ribosome activity, to produce hos...

nature.com

Vietnam reports H5N1 avian flu case with encephalitis Tests on respiratory samples were negative, but results were positive for the cerebrospinal fluid sample. www.cidrap.umn.edu/a...

Out now at @nature.com The entry receptor for enterovirus D68 👀 www.nature.com/articles/s41...

Aging might not be enough to eliminate H5N1 viruses in raw-milk cheese. #H5N1 www.cidrap.umn.edu/avian-influe...

Aging might not be enough to eliminate H5N1 viruses in raw-milk cheese

cidrap.umn.edu