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Jeff Maltas

@jeffmaltas.bsky.social

Studying therapy resistance through the lens of complex systems, ecology, and evolution. Assistant Professor of Biology, University of Maryland www.maltaslab.com

33 Posts295 Follower457 Folgt
Paper Skygest Team@paper-feed.bsky.social · last yr.

**Please repost** If you're enjoying Paper Skygest -- our personalized feed of academic content on Bluesky -- we'd appreciate you reposting this! We’ve found that the most effective way for us to reach new users and communities is through users sharing it with their network

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Juan Angueyra@juanonyme.bsky.social · 2mo ago

Preprint for the first manuscript of the Angueyra Lab is out! We delve deep into cell-fate decisions during photoreceptor development and discover that the 𝘵𝘣𝘹2 paralogues play multiple roles to control the fate of the five photoreceptor subtypes in zebrafish.

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 2mo ago

Transcriptional regulation by Tbx2 paralogs creates diversity within photoreceptor subtypes https://www.biorxiv.org/content/10.64898/2026.07.20.739565v1

Julia Van Etten@couchmicroscopy.bsky.social · 6mo ago

I have a new review out in TiG titled, “The ecology of horizontal gene transfer”! I’ve been thinking about these ideas for years and this field is growing so fast it’s becoming impossible to review it. I hope this paper sparks discussion on different ways we can look at DNA transfer!

The ecology of horizontal gene transfer

Horizontal gene transfer (HGT) generates genetic variation in populations across all domains of life; however, most studies focus on individual transf…

sciencedirect.com

Katie Mack@astrokatie.com · 7mo ago

I'm constantly trying (/failing) to get this point across. If you're a trained expert in a field, then it may be worthwhile to question the scientific consensus of your peers. If you're not, the scientific consensus is absolutely the best you can do and it's arbitrary foolishness to disregard it.

Vaughn Cooper@vscooper.micropopbio.org · last yr.

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine. 1) MMG (my dept): fundamental research in med micro 2) Peds ID / I4Kids institute 3) Center for Vaccine Research 🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Faculty Professor Associate - Full-Time | Vaughn Cooper

We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

linkedin.com

Andrew Steele@statto.bsky.social · 2y ago

WhatsApp is owned by Meta, the company behind Facebook, Instagram and, most recently, firing all their content moderators for political expediency. So this is a reminder to download Signal, a free messenger run by a nonprofit which is like WhatsApp but more secure and private: signal.org

Signal Messenger: Speak Freely

Say "hello" to a different messaging experience. An unexpected focus on privacy, combined with all of the features you expect.

signal.org

Jeff Maltas@jeffmaltas.bsky.social · 2y ago

Very excited to have this paper officially out. This one is pretty special... Unfortunately, @kevinwoodum.bsky.social passed away when this paper was in its final stages. He was my biggest supporter, and I miss him deeply as a mentor and friend.

PLOS Biology@plosbiology.org · 2y ago

Evolution of antibiotic resistance #AMR can lead to collateral resistance/sensitivity to other drugs; @jeffmaltas.bsky.social &co show that these effects can fluctuate over time, needing precise timing & stochastic control models to optimize treatment strategies 🧪 @plosbiology.org plos.io/3C2Ao1y

Success of switching to a second antibiotic is contingent on temporally dynamic collateral effects. Top: Twenty replicate populations of E. faecalis V583 were exposed to increasing concentrations of the antibiotic ceftriaxone over the course of 14 days via serial passage. At the end of each day, a sample of the population was isolated and cultured in a range of doxycycline concentrations for 24 h. Middle: Density (OD) after 24 h versus drug (DOX) concentration for all 20 populations (light gray), and the mean over the 20 populations (dark black) at different days of the evolution experiment. Bottom left: Average sensitivity over 20 populations (error bar standard error of the mean) at different time points. Bottom right: Collateral effects; dashed region highlights a transient six-day window where collateral sensitivity is more pronounced.