Mehdi Jafarnejad
@rnanomad.bsky.social
mRNA translation & RNA biology.... Principal Investigator @QubPGJCCR. https://jafarnejad-lab.com
We are extending the nomination deadline for the RNA Canada ARN awards! The deadline is now August 5th at 11:59 EST. These awards for the discovery, trainee, and volunteer of the year have prizes of $7 000, $2 000, and $1 000 respectively. For more information : www.rnacanada.ca/rna-canada-a...
rnacanada.ca
The AGO2 adaptor LIMD1 expands the functional and evolutionary reach of microRNA targeting | Science Advances www.science.org/doi/10.1126/...
The AGO2 adaptor LIMD1 expands the functional and evolutionary reach of microRNA targeting
LIMD1 helps AGO2 silence microRNA targets more effectively, revealing an additional layer of control beyond RNA sequence alone.
science.org
Great opportunity! We’re looking to hire a Platform Manager to lead the decelopment and operations of the @ircm.bsky.social RNA Therapeutics core facility. If you have solid expertise in #RNA biology, particularly in methodologies to synthesize and purify oligonucleotides, mRNA and LNPs, apply now!
workforcenow.adp.com
🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...
We have a new preprint!!! Our very talented PhD student Tom McGirr, along with our outstanding collaborators, show that translational attenuation is critical for avoiding proteotoxic stress upon exposure to ionizing radiation. #RNASky, #RNA, www.biorxiv.org/content/10.6...
GIGYF2/4EHP-Mediated Translational Attenuation Maintains Cellular Homeostasis Following Ionizing Radiation
Translational regulation is a critical component of the cellular response to environmental stress. Ionizing radiation (IR) exists naturally at low doses (e.g., cosmic rays and radioactive materials) b...
biorxiv.org
We're no longer asking whether mRNA works. We're refining it. New in Nature: ac4C, an mRNA modification that boosts protein yield AND accuracy, reducing translational errors. This is what a maturing platform looks like—precision, molecule by molecule. 🔗 www.nature.com/articles/s41...
N4-Acetylcytidine enhances synthetic mRNA translation yield and fidelity - Nature
Different RNA modifications elicit different translation elongation rates for in vitro transcribed mRNAs that result in disparate translation outputs and fidelity, as shown here for N4-acetylcytidine ...
nature.com
Very glad to have our latest study, led by the former stellar PhD student @pharrissnell.bsky.social and postdoc Parisa Naeli, out in @cp-cellreports.bsky.social. Translation-dependent regulation of stability of non-optimal mRNAs by 2 vertebrate-specific RBPs, ZC3H7A/B. www.cell.com/cell-reports...
Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins
Harris Snell et al. report that ZC3H7A and ZC3H7B, two chordate-specific RNA-binding proteins, directly bind and coordinate the decay and translational regulation of A/U3-rich non-optimal mRNAs. By re...
cell.com
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions: Molecular Cell www.cell.com/molecular-ce...
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions
Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...
cell.com
Looking for a truly unique PhD programme on RNA drugs and therapeutics? We have just opened the call for the second cohort of RNAmed-Future leaders in RNA-based medicine. More details under www.rnamed.de Please spread the word.
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
nature.com
Answer to a key and longstanding question; How does the integrated stress response terminate? | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
science.org
There ain’t much that eIF3 doesn’t do! Very nice (and rather comprehensive) review on all things eIF3. link.springer.com/article/10.1...
eIF3 musketeers: loyal in health, rogue in disease, and redeemed by therapeutic targeting - The EMBO Journal
The eukaryotic translation initiation factor 3 (eIF3) is the largest and most complex initiation factor in eukaryotes, functioning as a central hub that integrates signals from cellular stress, metabo...
link.springer.com
This is brilliant!
Kranzusch Lab@kranzuschlab.bsky.social · 6mo agoMax Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps: www.cell.com/cell/fulltex...
eIF5B-Driven Translational Control Impacts Oral Squamous Cell Carcinoma Pathophysiology. From the talented PhD student Pavan Narasimha in Nehal Takhor lab. Great to see this work out in preprint and looking forward to more cool stuff from Pavan's recent works! www.biorxiv.org/content/10.6...
biorxiv.org
⭐NAR Breakthrough! ⭐ #RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪. Read the full article here: doi.org/10.1093/nar/...
Join us; We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system. #Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs hrwebapp.qub.ac.uk/tlive_webrec...
Job profile
hrwebapp.qub.ac.uk
Just out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology
RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...
nature.com
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
Very much looking forward to hosting @alf-castello.bsky.social for this talk as part of the @irishrna.bsky.social online lecture series. Don’t miss it if either host-virus interactions, RNA-binding proteins, or both are interesting to you!
All-Ireland RNA club@irishrna.bsky.social · 7mo agoHappy New Year from the All-Ireland RNA Club. We are starting the year with an exciting online seminar this Friday! Get in touch with martina.schroeder@mu.ie if you want the Teams link and are not on our mailing list. @rnasociety.bsky.social #RNASalon
⭐NAR Breakthrough! ⭐ 🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival. 🧬Read more: doi.org/10.1093/nar/...
We can learn a lot about our own biology just by figuring out how viruses hack our systems! Avoid mRNA circularization to scape the codon usage trap set by the host. www.nature.com/articles/s41...
Viral RNA blocks circularization to evade host codon usage control - Nature
Rather than adapting to the codon usage of their host, viruses use viral 5′ untranslated regions to initiate translation, which allows them to produce viral proteins in host cells efficiently despite ...
nature.com
New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...
ZAKα is a sensor of mRNA stasis at the ribosomal exit channel
Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...
biorxiv.org
RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions academic.oup.com/nar/article/...
RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions
Abstract. RNA–protein complexes have emerged as central players in numerous key cellular processes with significant relevance in health and disease. To fur
academic.oup.com
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
nature.com
Programmable initiation of mRNA translation by trans-RNA - @cornelluniversity.bsky.social @iecb.bsky.social go.nature.com/3K7SEdO
Programmable initiation of mRNA translation by trans-RNA - Nature Biotechnology
Translation can be initiated from a specific start codon using trans-RNA.
go.nature.com
We’ll soon be advertising a postdoc position (3 years) to study how mRNA-specific translational regulation shapes the innate immune system, in collaboration with @alf-castello.bsky.social. The formal ad will be out soon but get in touch if you’d like an informal chat! #RNASky
🚨 New paper alert!! RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells. A new mechanism showing how post-transcriptional control keeps our immune cells in check! #RNA #Bcells #GenomeStability www.science.org/doi/10.1126/...
RNA binding proteins control the G2-M checkpoint of the germinal center B cell
Germinal center B cells rely on ZFP36L1 and ZFP36L2 to control cell division and avoid replication stress that leads to apoptosis.
science.org
