📣 Abstract submission deadline for CSHL TEs extended to July 24! Two more weeks to submit your abstract for a short talk or poster — do it! It’s gonna be a fantastic meeting!! meetings.cshl.edu/meetings.asp...

Transposable Elements

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

Cedric Feschotte@cedricfeschotte.bsky.social · 3mo ago

👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...

Thank you to organisers to James Hombría and Antónia Monteiro @monteirolab.bsky.social and everyone who joined us at this week's Workshop on 'Novelty, Co-option and Divergence During Gene Network Evolution' biologists.com/workshops #BiologistsWorkshops

Cannot express how much fun I had the past few days at the workshop “Novelty, Co-option and Divergence During Gene Network Evolution” organized by James Hombría and Antónia Monteiro ! This would not have been possible without the support of @biologists.bsky.social

New preprint! We show that cell fate can be predicted from a snapshot of combinatorial signaling — and the underlying map is a single angle in signaling space. Work by first authors Bassit Fijabi and Seth Teague and collaboration with @davidbrueckner.bsky.social. www.biorxiv.org/content/10.6...

Two new papers 📖 from our lab 1️⃣ What is epigenetics (and why X inactivation is?) rdcu.be/fhzSz and 2️⃣ A Baculovirus-based tool to express any gene of interest with high efficiency in Anopheles cells rdcu.be/fhzTy

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

But wait! There’s more! So you thought you knew nucleosome structure? Think again! @vram142.bsky.social @gladstoneinst.bsky.social and @genophoria.bsky.social @arcinstitute.org show that there is plenty of distortion largely due to TFs butting in www.nature.com/articles/s41...

Pervasive and programmed nucleosome distortion on single chromatin fibres - Nature

An analytical pipeline called Iteratively Defined Lengths of Inaccessibility (IDLI) maps the genome-wide occupancy of a range of nucleosome types and shows that most nucleosomes exhibit programmed ‘di...

nature.com

now published at BMC Biology! rdcu.be/fdITD

@sandraduharcourt.bsky.social · 9mo ago

Excited to share our new preprint on BioRxiv! A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1... 1/5

Really happy to share that our preprint is now published in @narjournal.bsky.social! 🎉

A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination

Abstract. Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In t

academic.oup.com

Thomas Balan@thomasbalan.bsky.social · 10mo ago

🚨 Excited to share my first preprint on bioRxiv! 🎓 We uncover a non-canonical role of condensin I, beyond chromosome segregation 🧬 This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs! ➡️ doi.org/10.1101/2025...

Our latest publication is now out at Genome Biology! link.springer.com/article/10.1... We uncover a unique association between a H3K27me3 reader complex and active transcription. A thread with our key findings: (1/8) #TEsky #Polycomb #transcription #smallRNAs

A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology

Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

link.springer.com

Very happy to have been selected for the Young investigator award ✨ See you in Copenhangen folks ! Many thanks to @official-smbe.bsky.social !!

Society for Molecular Biology and Evolution@official-smbe.bsky.social · 5mo ago

🏅 Recipients of the different SMBE 2026 awards have now been notified. If you didn’t receive a message, you were unfortunately not selected this time. The conference remains open to all interested participants, and we’d love to see you in Copenhagen. 🔗 smbe2026.org #SMBE2026

I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳 Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/... #TEsky #RNAsky #RNAbiology #immunity #NAR

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev

academic.oup.com

I'm looking for a Swiss department to host me for an SNSF Starting Grant. I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com If your department might be a match, let’s chat!

⚡👩‍🔬Electrical signals are key for promoting organ regenerative growth, a new study! Out now in Science Advances, from the Mateus group @ritamateus.bsky.social at PoL and @mpi-cbg.de along with the lab of Frank Jülicher @mpipks.bsky.social Read the news here: tud.link/7jzptz Video:©️ Mateus group

This feeling of panic when university tells you that ordering system will undergo change+you cannot order for 10 days 😰Tried to order primers ahead of time but as new data come in, I feel paralyzed to not react+plan follow-up experiments😆 Even after being PI for 17yrs, my❤️ for science never changed!

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports.... Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity

Milovanović et al. uncover a mechanism by which KZFPs restrict the activity of transposon-derived cis-regulatory elements to safeguard cardiomyocyte functionality. This work extends the classical TE-K...

cell.com

🚨 The final version is out: how transposons help keep our hearts beating ❤️ Proud of this one with @1995dana.bsky.social, huge thanks to @trono-lab.bsky.social. Give it a read! #TEsky

Danica Milovanović@1995dana.bsky.social · 6mo ago

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports.... Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

New paper: Remodeling of XIST regulatory landscape during primate evolution We are glad to share with you our latest publication investigating the evolution of XIST regulation in primates ES cells. urlr.me/eyG38M @manucazottes.bsky.social @crougeulle.bsky.social @charbel-alfeghaly.bsky.social

We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...

Sven Klumpe@svenklumpe.bsky.social · last yr.

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

Our work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41... Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)

This is the equivalent of Jesus on a toast for developmental biologists 🧪

Christmas has come early. Fantastic to see this beautiful study from Peter Rugg-Gunn's lab at The Babraham Institute published today. Congratulations to Matteo Mole, Sarah Elderkin, Irene Zorzan and all other authors! www.cell.com/cell/fulltex...

Modeling human embryo implantation in vitro

Building an in vitro model of receptive endometrium allows investigation of human embryo implantation and early post-implantation development and recapitulates the earliest stages in establishing the ...

cell.com

🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....

Michelle Percharde@mpercharde.bsky.social · 2y ago

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

🚨 New paper out! A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development Here is the full paper: rdcu.be/eSWEs 🧵 A twittorial: THREAD

A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development

Nature Cell Biology - The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is...

rdcu.be

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Escape from X inactivation is directly modulated by Xist noncoding RNA

Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

rdcu.be

Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC). 📍 Renaissance Tuscany Il Ciocco (Italy) 🗓️ March 22 - 27, 2026 Theme: "Molecular Codes of Cell Identity and Recognition" #LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime

Attending #EMBOevoChromo25 next week? Our Reviews Editor @ingridtsang.bsky.social will be attending - feel free to talk to her about the journal or @biologists.bsky.social activities!

EMBO@embo.org · last yr.

Learn about #chromatin and #evolution at EMBO Workshop "EvoChromo: Evolutionary approaches to research in chromatin" in Sant Feliu de Guixols, Spain, 9–12 December 2025 Deadline: 10 September 2025 meetings.embo.org/event/24-evo... #EMBOevoChromo25 #EMBOevents 🧪

The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk

Happy to present TOGA2, developed by Yury Malovichko @ymalovichko.bsky.social, the faster, memory-efficient & more accurate TOGA1 successor (github.com/hillerlab/TO...). And annotations, orthologs & gene loss/dup data generated with 4 references for 883 placental mammal and with 5 refs for 676 ...

Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...

Q & A

Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard Univ...

cell.com