Preprint Review @TheSainsburyLab FTW I said it and I say it again: high-profile papers that don't get preprinted are suspicious. BAD ACTORS DON’T PREPRINT. www.tsl.ac.uk/science-comm...

I am delighted to share the final version of our latest study, led by the extraordinary PhD student Jiaoqi Cheng. We developed CenSegNet, a generalist AI framework for large-scale mapping of centrosome phenotypes at both spatial and single-cell resolution. (1/6) www.nature.com/articles/s41...

On 19th Sept @britsciassoc.bsky.social festival join @theeliaslab.bsky.social @clarkinbonebiol.bsky.social @owenrackham.bsky.social & other researchers🔬, artists🎨poets schools 🎓 to explore how AI & 3D imaging are uncovering hidden diseases in our bones 🦴 and detecting cancer earlier 👇#bsf2026

Invisible illness through AI eyes | British Science Festival

This drop in event runs from 11.00 – 17.00 AI has the potential to transform our understanding of hidden diseases. Doctors use specialist medical imaging to uncover what’s beneath the skin – think X…

britishsciencefestival.org

Biological Sciences@sotonbiosciences.bsky.social · last mo.

We are very excited to be a part of the @britsciassoc.bsky.social festival this year 🥳 More details to follow!!!

I am delighted to share the final version of our latest study, led by the extraordinary PhD student Jiaoqi Cheng. We developed CenSegNet, a generalist AI framework for large-scale mapping of centrosome phenotypes at both spatial and single-cell resolution. (1/6) www.nature.com/articles/s41...

Proud of Jiaoqi Cheng who has successfully passed her PhD viva 🎉 🎓Many thanks to her examiners, Susana Godinho @susanagodinho.bsky.social and Charlie Birts @sotonbiosciences.bsky.social #theeliaslab

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo

A 🆕 #Ichthyosporea story Led by@margaridaaraujo.bsky.social, in Co. @gautamdey.bsky.social & @hiralshah.bsky.social+🔥team across @embl.org & @sciencesunige.bsky.social We finally have a look at what #microtubules are doing during #cellularization in #Sphaeroforma ▶️ tinyurl.com/MTSARC #ProtistsOnSky

2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word. crick.ac.uk/WayPostdoc20...

Throughout the year, our community has been sharing stories with us about how The Company of Biologists has supported you over time. Your stories were heartfelt, and we feel grateful and humbled that we have been able to be part of your journeys. bit.ly/4q7C0Ki

Excited to share our latest work exploring the link between aging, pregnancy, and breast cancer risk. 🧬 nature.com/articles/s41...

Last newsletter of 2025 highlighting a few of GetGenome’s recent activities.

GetGenome@getgenome.bsky.social · 8mo ago

I just published: GetGenome in 2025: onward and upward 2025 was a big year for @GetGenome. We doubled down on our mission to democratize genomics, connect early-career researchers, and amplify microbial voices from every corner of the planet. medium.com/p/getgenome-...

I just published: GetGenome in 2025: onward and upward 2025 was a big year for @GetGenome. We doubled down on our mission to democratize genomics, connect early-career researchers, and amplify microbial voices from every corner of the planet. medium.com/p/getgenome-...

GetGenome in 2025: onward and upward

2025 was a big year for GetGenome. We doubled down on our mission to democratize genomics, connect early-career researchers, and amplify…

medium.com

Humbled and honoured to join this club, alongside some of my scientific heroes and colleagues. Grateful to my team, collaborators, and mentors &, just as much, to my wife, family and friends.

Life Sciences Switzerland (LS2)@lifesciswitzerland.bsky.social · 8mo ago

Congratulations to Prof. Omaya Dudin for receiving the Friedrich Miescher Award 2026! Find out more: www.ls2.ch/awards/fried... Prof. Dudin will present his award lecture at the LS2 Annual Meeting 2026 in Zurich: annual-meeting.ls2.ch/2026 @dudinlab.bsky.social @fmiscience.bsky.social

Congratulations to Prof. Omaya Dudin for receiving the Friedrich Miescher Award 2026! Find out more: www.ls2.ch/awards/fried... Prof. Dudin will present his award lecture at the LS2 Annual Meeting 2026 in Zurich: annual-meeting.ls2.ch/2026 @dudinlab.bsky.social @fmiscience.bsky.social

Quite a busy day on #Bluesky ! Been a while since we have been #preLight -ed ! Discover HAK-Actin if you haven't already ;)

preLights@prelights.bsky.social · 9mo ago

Reliable actin labelling in expansion #microscopy 🔬 Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social Read the latest #preLight from @kanishka03.bsky.social ⬇️👀 prelights.biologists.com/highlights/h...

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

So sad to hear the news - John truly was an inspiration to so many, and one of a kind. www.cam.ac.uk/research/new...

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

cam.ac.uk

Are you looking for a reliable strategy to quantify the architecture of mammary tissue using whole mount images?? Well, maybe you should check MaGNet, our new computational based and user friendly approach (and you probably can adapt it to other organs as well). link.springer.com/article/10.1...

MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice - Journal of Mammary Gland Biology and Neoplasia

The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A common approach in mammary gland biology is the evaluation of branching morphogenesis to characterize the role of developmental, physiological and molecular perturbations on branching tissue invasion, growth, and maintenance. Yet, the field still lacks a fully open-sourced, quantitative framework to analyze whole-mount mammary tissue images, as a commonly utilized methodology. Here, we present MaGNet (Mammary Gland Network analysis tool), a method that leverages network theory to characterize key features of ductal branching during mammary gland development. Applying this pipeline to mammary gland images captured at three pubertal timepoints, we achieved reproducible quantification of ductal tree expansion across development. In addition, this network analysis pipeline captures ductal expansion induced by pregnancy hormones. By providing open-source tools to the research community, this method may increase reproducibility and broad applicability across diverse organ systems, model organisms, and developmental stages.

link.springer.com

Excited to share our new preprint introducing CenSegNet, a deep learning framework for high-throughput, spatially resolved and single-cell centrosome profiling in heterogeneous tissues. A huge effort co-led by brilliant PhD students, Jiaoqi Cheng & Keqiang Fan. 1/3 www.biorxiv.org/content/10.1...

CenSegNet: a generalist high-throughput deep learning framework for centrosome phenotyping at spatial and single-cell resolution in heterogeneous tissues

Centrosome amplification (CA) is a hallmark of epithelial cancers, yet its spatial complexity and phenotypic heterogeneity remain poorly resolved due to limitations in conventional image analysis. We ...

biorxiv.org

Excited to share our new preprint introducing CenSegNet, a deep learning framework for high-throughput, spatially resolved and single-cell centrosome profiling in heterogeneous tissues. A huge effort co-led by brilliant PhD students, Jiaoqi Cheng & Keqiang Fan. 1/3 www.biorxiv.org/content/10.1...

CenSegNet: a generalist high-throughput deep learning framework for centrosome phenotyping at spatial and single-cell resolution in heterogeneous tissues

Centrosome amplification (CA) is a hallmark of epithelial cancers, yet its spatial complexity and phenotypic heterogeneity remain poorly resolved due to limitations in conventional image analysis. We ...

biorxiv.org

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

The #PrimaryCilium dynamically assembles & disassembles, but how is this controlled? @cytolabkoc.bsky.social shows that #ciliopathy linked protein Ccdc66 regulates both #cilium stability & length in epithelial cells via microtubules, actin & vesicular trafficking @plosbiology.org 🧪 plos.io/4mdTS4A

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription. www.cell.com/cell/fulltex... Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites

Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...

cell.com

A short break from paper writing, with family

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences

Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

lms.mrc.ac.uk

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

nature.com

I just published: Why I’m skipping the Congress this year (And why you should still publish your posters) Publishing your poster creates a citable record and protects you from bad actors. #ISMPMI2025 #OpenMPMI #AcademicChatter #PhDchat medium.com/p/why-im-ski...

Why I’m skipping the Congress this year (And why you should still publish your posters)

Publishing your poster creates a verifiable and citable record of your work. It also protects you from bad actors — the evidence will be…

medium.com

“Want to know which papers are flawed…the ones that don’t get preprinted” Not the first time I’ve heard people say this.

Sophien Kamoun@kamounlab.bsky.social · last yr.

I just published: Why I’m skipping the Congress this year (And why you should still publish your posters) Publishing your poster creates a citable record and protects you from bad actors. #ISMPMI2025 #OpenMPMI #AcademicChatter #PhDchat medium.com/p/why-im-ski...

Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors @tolgaboz.bsky.social and @jiorgoskourelis.bsky.social labs: www.jobs.ac.uk/job/DNV032/r...

Research Associate in Programmable Plant Immunity at Imperial College London

Apply for the Research Associate in Programmable Plant Immunity role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

jobs.ac.uk