Deniz Fraemke

@denizfraemke.bsky.social

PhD Candidate | GxE Interplay of cognitive development and educational attainment at Max-Planck Research Group „Biosocial“

Why do people stop pursuing goals they care about❓ Motivational deficits are among the most disabling symptoms, yet current treatments often have only modest effects. In @lillyt.bsky.social new paper, she asks if we're missing an important piece of the puzzle 🧠 #neuroscience #cogpsyc #psychscisky

Arousal shapes motivation: an integrative framework for understanding motivational deficits - Translational Psychiatry

Translational Psychiatry - Arousal shapes motivation: an integrative framework for understanding motivational deficits

nature.com

Heritability = one of the most commonly confused concepts in public (mis)understanding of genetics. Let’s break it down. Imagine studying a cohort of people in a specific set of environmental circumstances. You assess everyone for an observable trait & find it varies from one person to another. 🧪1/5

The populations in East&West Germany were far from being randomly selected groups: 1. the later border is already visible in pre-WWII data 2. WWII & the subsequent occupying forces affected East & West differently 3. a selective fifth fled from East 2 West Germany before the building of the Wall

Stephanie Wang@sweiwang.bsky.social · 3mo ago

are you familiar with this terrific paper in the JEP by @essobecker.bsky.social @lukasmergele.bsky.social @woessmann.bsky.social www.aeaweb.org/articles?id=...

Last week, I mentioned this in passing in a workshop: In 1938 Enrico Fermi won a Nobel Prize for discovering two new elements of the periodic table. Lise Meitner shortly showed that Fermi was mistaken and instead had produced known lighter elements by fission. She did not win a Nobel prize.

Portrait of Lise Meitner taken in 1928. She is smoking a cigarette and looking impatient to get back to her experiments.

I wrote about Nucleus Genomics' "Have your best baby" ad campaign and Kris Jenner's "best version of myself" facelift, the parallels between embryo selection and cosmetic surgery, and competing definitions of "eugenics" kathrynpaigeharden.substack.com/p/have-your-...

"Have Your Best Baby"

Four parallels between cosmetic surgery and polygenic embryo selection, two competing definitions of "eugenics," and one short excerpt from my forthcoming book

kathrynpaigeharden.substack.com

I'm working on some figures for a book to illustrate the foundation of quantitative genetics (as confirmed by GWAS a century later). Mendel showed discrete inheritance in peas (left figure, 1860s). Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).

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I drafted a letter to the editor, please help me out by DMing, commenting, emailing feedback if you are an expert on colliderbias, id obviosuly ad you as a author, Ideally we submit within 24-48 hrs, draft: zenodo.org/records/1800... (click download if the pdf doesnt preview on zenodo)

Negative Associations Between Early and Adult Performance Arise from Colider Selection Bias

Güllich et al. argue that among elite performers there is a negative associationbetween early and adult performance, a pattern they link to distinct developmentalcausal mechanisms for early, and adult...

zenodo.org

Within Anomaly’s defense of eugenics, one passage in his book especially alarmed me. It implies that his advocacy for “free reproductive choice” applies only when people choose to 'enhance' — since once an “enhanced” majority exists, those who refuse may face coercion or exclusion from reproduction.

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Sasha Gusev@sashagusevposts.bsky.social · 8mo ago

I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

Mapping the genetic landscape across 14 psychiatric disorders - Nature

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...

nature.com