Unpacking into our new house and I found this. Many happy evenings at He’s not. And many science discussions!

🧵 El verano de 2026 por ahora (junio-julio) es el más cálido de la serie histórica en España, que arranca en 1961. ➡️ Con una temperatura media de 24,5 ºC, supera en 0,7 ºC a los bimestres junio-julio más cálidos, los de 2022 y 2025. Es 2,9 ºC más cálido que el promedio 1991-2020.

To what extent is cancer development deterministic? Does the germline genome affect that predictability? We re-ran cancer evolution to answer these questions. www.nature.com/articles/s41...

I have my own racks! And they’re new!

Bienvenidas las #Plazas de investigación, los contratos #ATRAE, #RyC, etc. Pero si no se inyecta más dinero en el sistema, eso solo sirve para que se rechacen más proyectos. Y los que se conceden, se quedan con una financiación estancada desde hace 5 años, que no cubre siquiera la inflación. 😠

Jose A. Esteban@jaestebancbm.bsky.social · 4w ago

Y si queréis ver la tendencia de los últimos años: - Está subiendo mucho el número de solicitudes (casi un 10% respecto al año pasado). - La financiación total no sube al mismo ritmo (un 5,7%). - La financiación media por proyecto se mantiene. - Conclusión: se rechazan más proyectos.

Muchos ya habréis visto la resolución provisional de los proyectos #PID2025 de la @ageinves.bsky.social Aquí va la distribución. La financiación media por proyecto se ha quedado como el año pasado. Y seguimos con 2/3 de los proyectos con <50 k€ por año. ☹️ www.aei.gob.es/convocatoria...

Delighted to share that I’ll be sticking around at Michigan to start my lab in the Department of Human Genetics! Starting in May 2027, the Tovar lab will use functional genomics to study transcription factor biology and regulatory network dynamics in complex disease. Stay tuned for more details…

Chromosome loss is detrimental to cellular fitness, yet can be one of the earliest events in cancer. How can a deleterious genomic alteration initiate tumorigenesis? 🤔 Our latest preprint tackles this paradox using clear cell renal cell carcinoma (ccRCC) as a model. www.biorxiv.org/content/10.6...

A single chromosome 3p break initiates clear cell renal cell carcinoma evolution

Clear cell renal cell carcinoma (ccRCC) is initiated by chromosome 3p loss, yet chromosome losses impose a profound fitness burden on normal cells. How renal epithelial cells tolerate this deleterious...

biorxiv.org

Lo de Balogun es un escándalo tan grande como me parece, ¿no?

We teamed with Jim Crott's lab at BU to show that administration of freeze-dried Parabacteroides distasonis extends Drosophila mean lifespan by preventing leaky guts. How? Maybe hormesis. A fun collaboration that features the work of 8 Tufts undergraduates! www.aginganddisease.org/EN/10.14336/...

Now published on @narjournal.bsky.social ! academic.oup.com/nar/article/...

Processing of reversed replication forks is required for the resolution of replication-transcription conflicts

Abstract. DNA replication and transcription occur simultaneously on the same template, leading to conflicts between the two machineries. Conflicts stall re

academic.oup.com

Juan Carvajal Garcia@jucarvag.bsky.social · 5mo ago

Third first-author and first (co-)corresponding author pre-print from my postdoc! In which we do a whole-genome transposon screen to determine how replication-transcription conflicts are resolved in Bacillus subtilis. Check out! www.biorxiv.org/content/10.6...

Join us! Postdoc position (2-3 years) in our lab @molbiolau.bsky.social Looking for candidates with experience in cell culture, genome editing, biochemistry, and/or structural biology. Application opens in August via AU's system but informal enquiries by email are welcome from now. (1/2)

Related: if you know a great undergrad interested in grad school (or if YOU are interested), & they'd like to work in fungal biology using population genomics to study pathogenicity and genome plasticity, please encourage them to reach out! See annehatmaker.com/contact/ for more info on how

Annie Hatmaker, Ph.D.@annemakerofhats.bsky.social · 3mo ago

I shared on LinkedIn already, but I wanted to post here as well since I've got a different audience: I will be joining the Department of Plant Pathology at the @universityofga.bsky.social as an Assistant Professor on Aug 1!! I will keep studying #Aspergillus & #Fusarium that infect plants & humans 🥰

Paper accepted!

Juan Carvajal Garcia@jucarvag.bsky.social · 5mo ago

Third first-author and first (co-)corresponding author pre-print from my postdoc! In which we do a whole-genome transposon screen to determine how replication-transcription conflicts are resolved in Bacillus subtilis. Check out! www.biorxiv.org/content/10.6...

I will be recruiting research technicians and post-bac fellows and accepting rotation students beginning in fall 2027. Please email me or ask to chat at the FASEB Genetic Recombination and Genome Rearrangements meeting in July if you are interested!

First conference as (almost) PI!

Today is the last day of 11 magnificent years living in the United States. Today, I move back to Spain. I came as a 22 year old aspiring scientist and I’m coming back with a wonderful wife, and the best scientist I could become. And of course, with little Mango.

Extended abstract deadline (June 7th) for FASEB Dynamic DNA Structures in Scottsdale, AZ July 19-24. Speaking slots still open, and scholarships available for trainees (grad students and postdocs). Let your colleagues know! events.faseb.org/event/Dynami...

Last night out in Nashville

Carolyn started this as a whole-genome revisit of the classic 1996 papers on spontaneous nondisjunction from Hawley (Dros X) and Sherman (human 21) labs. She looked at a metacentric (Dros 2) and found that the rules are different - no obvious relationship between ndj and crossovers. Shape matters!

Genetics Society of America@genetics-gsa.bsky.social · 2mo ago

Carolyn Turcotte and @jeffsekelsky.bsky.social employed whole-genome sequencing to study spontaneous meiotic nondisjunction of the metacentric chromosome 2 in #Drosophila, identifying chromosome-specific mechanisms of meiotic nondisjunction. 🪰 Learn more in #GENETICS: 🔗 buff.ly/LmC3qZU

Last (?) preprint as a postdoc in the Merrikh lab! Awesome collaborative effort with graduate student Oyku! I hope people give it a read!

bioRxivpreprint@biorxivpreprint.bsky.social · 2mo ago

Polynucleotide Phosphorylase Stops Replication Restart by Degrading the RNA within R-loops during Replication-Transcription Conflicts https://www.biorxiv.org/content/10.64898/2026.06.02.729377v1

Polynucleotide Phosphorylase Stops Replication Restart by Degrading the RNA within R-loops during Replication-Transcription Conflicts https://www.biorxiv.org/content/10.64898/2026.06.02.729377v1

The Ly Lab is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏 Full posting: cri.utsw.edu/careers/

This is beautiful and soccer is wonderful.

Zohran Kwame Mamdani@zohrankmamdani.bsky.social · 3mo ago

“Why argue with an Arsenal fan when you can just wait?” We waited. We won. We are champions of England - and we are just one game away from being crowned champions of Europe. Read my piece on what Arsenal means to me here: www.nytimes.com/athletic/731...

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

is this dataset a candidate for SubtiWiki incorporation, @joergstuelke.bsky.social?

Ákos T Kovács@evolvedbiofilm.bsky.social · 3mo ago

"compact pooled CRISPRi library targeting all protein-coding genes in B. subtilis and test its growth in ~150 stress conditions" The phenotypic landscape of the model firmicute Bacillus subtilis bioRxiv from Carol Gross www.biorxiv.org/content/10.6...

US universities genuinely are like “welcome to Tennessee Agricultural College in Bumfuck Nowheresville. We invented the modern potato and our facilities include a particle accelerator, nuclear reactor, and TOP500 supercomputer. Tuition is $12,000 for instate students and we have 40,000 of them”

Excited to drop our visual systems pre-print 10 years in the making. We hacked nature's cheat code to protect the eye from light damage. This unexpectedly also boosts rod sensitivity. Huge thanks to collabs Tonia Rex, @amandalea.bsky.social , Alex Bick, and their labs! @evolutionvu.bsky.social

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 3mo ago

Rhodopsin is a tunable capacitor buffering the toxic, desensitizing retinoids of the vertebrate eye https://www.biorxiv.org/content/10.64898/2026.05.05.722510v1

Abstract deadline approaching (May 24) for FASEB Dynamic DNA Structures in Scottsdale, AZ July 19-24. This is a not-to-miss conference if you're interested in the intersection of nucleic acid structures and human health. Speaking slots still open! Please repost. events.faseb.org/event/Dynami...

My lab is currently hiring at the Research Technician level. This would be a great opportunity for a recent graduate looking to gain additional research experience prior to applying to graduate school! Job ad below: careers.uvahealth.org/us/en/job/R0...

Lab Technician 1 or 2 in Biochemistry & Molecular Genetics-Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia Health System

Apply for Lab Technician 1 or 2 in Biochemistry & Molecular Genetics-Weaver Lab job with University of Virginia Health System in Charlottesville, Virginia, United States of America. Research at Univer...

careers.uvahealth.org