Mathew Jones
@jonesmjk.bsky.social
Investigating kinase-dependent regulation of DNA replication and repair
Happy to share our new review on 3D chromatin organisation by cohesin with you. It was a great pleasure to review recent advances and future prospects with @danielgerlich.bsky.social.
Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 7mo agoNew Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion
Pleased to see our latest research highlighted news.uq.edu.au/2025-10-ai-p...
AI-powered genomics platform brings hope for better cancer treatments
Researchers from the University of Queensland and University of Cambridge have developed a platform for human cells powered by artificial intelligence that could aid the development of therapeutics an...
news.uq.edu.au
For decades, human genome editing has been limited to small, localized modifications. Today, in a new paper published in @science.org , researchers from Arc's Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
CAR T cells showcase the enormous potential of cell therapies, but often fail due to lack of evolutionary optimization. Today in @nature.com , we use #CELLFIE to engineer cell therapies at scale and share the largest resource of CRISPR screens in CAR T cells. www.nature.com/articles/s41...
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
nature.com
Fantastic meeting with an excellent line up of speakers. Come join us for the Australian Cell Cycle meeting in Melbourne.
Andrew Deans@genomestability.bsky.social · 10mo agoAustralian Cell Cycle, DNA repair and Telomere meeting draft schedule is now online! Join us with 5 plenary speakers, 16 invited national speakers, 22 selected speakers, 61 poster presenters and lots and lots of fun science. Less than one month to go. australiancellcycle.org/draft-schedu...
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
nature.com
1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...
An electrostatic repulsion model of centromere organisation
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
doi.org
🦘🧬Australian invited speaker list finalised for the 2025 Cell Cycle, DNA repair and Telomere Meeting! Friday 5 Sep is your last chance to register at the EARLY BIRD rate & submit an abstract 🤩 australiancellcycle.org/australian-i...
Australian Invited Speakers 2025
We are in the process of inviting a number of outstanding Australian leaders in the fields of DNA repair, Cell Cycle and Telomere biology. Current invited speakers include: Lisa Alcock, Curtain Uni…
australiancellcycle.org
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels. www.nature.com/articles/s41...
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications
The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…
nature.com
Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
rdcu.be
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
#NEW_PAPER In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR). rdcu.be/eCGxF
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...
rdcu.be
This insightful manuscript implicating STAG3 in mitotic, rather than the known meiotic, control of chromatin architecture came out a couple of days ago. Glad to see it in our pages @natsmb.nature.com and I am looking forward to see what the community will think www.nature.com/articles/s41...
The mitotic STAG3–cohesin complex shapes male germline nucleome - Nature Structural & Molecular Biology
Nagano et al. identify the third mitotic cohesin complex, STAG3–cohesin, which, with its unique biophysical properties, weakens insulation and rewires regulatory interactions of spermatogonial stem ce...
nature.com
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.
dlvr.it
Nature research paper: Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors go.nature.com/45JauuG
Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature
Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.
go.nature.com
ICYMI: New Online! Snoozing APC/C for a sweet cell cycle entry
Snoozing APC/C for a sweet cell cycle entry
Nature Reviews Molecular Cell Biology, Published online: 21 August 2025; doi:10.1038/s41580-025-00891-8Paul et al. demonstrate that entry into the cell cycle from quiescence involves a transient, partial inactivation of the APC/C ubiquitin ligase, which halts the degradation of glycolysis enzymes and ensures sufficient ATP production for cell division.
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