The Downs Lab
@thedownslab.bsky.social
The Downs lab at the Institute of Cancer Research in London, studying chromatin biology and genome stability. thedownslab.org
Interested in mechanobiology, transcription factors and stem cell differentiation? Please check out this postdoc opportunity between my lab @imperiallifesci.bsky.social and the lab of Maxim Molodtsov @mmlab.bsky.social @crick.ac.uk (Deadline: 6 January 2027): www.crick.ac.uk/careers-stud...
Mechanical control of gene expression
crick.ac.uk
We’re hiring! 🧬 We're looking for a Postdoctoral Training Fellow to join our group at the ICR in London and work on chromatin biology, transcription regulation and AML. Curious about how histone modifications shape gene regulation and cell identity? Come join us! jobs.icr.ac.uk/vacancies/15...
Postdoctoral Training Fellow - Chromatin Biology and Epigenetics in Chelsea | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Chromatin Biology and Epigenetics vacancy in Chelsea . Salary: Salary range £45,600 - £51,450 per annum. Dependent on re...
jobs.icr.ac.uk
So nice to see Pierre's @pierrecaron.bsky.social highlight of our preprint (led by @lillianwu.bsky.social ) was selected by @jcellsci.bsky.social to include in their latest issue. Also, what a great initiative - ended up reading them all! prelights.biologists.com/highlights/c...
CENP-B binds hairpin motifs in chromosome arms influencing gene expression - preLights
CENP-B escapes the centromere and plays a surprising role in gene regulation
prelights.biologists.com
It's a wrap! Thanks to all the organisers (@haicovanattikum.bsky.social, @titiasixma.bsky.social, @sylvie-noordermeer.bsky.social, @luijsterburglab.bsky.social, @thedownslab.bsky.social, and many others) for assembling this fantastic conference. One of the best meetings I have attended so far!
Basil Greber@bjgreber.bsky.social · 6mo agoIt is almost over, so this seems to be a good time to share a few photos taken during the DNA repair meeting in Egmond aan Zee (mostly in the early mornings before sessions). What a fantastic setting to hold a conference!
Only few days left to submit an abstract for our second annual QMUL centre for epigenetics meeting in June in London! Deadline 3rd may! Details below
QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 7mo agoWe're excited to announced that our 2nd Annual QMUL Centre for Epigenetics Conference is happening on June 18th, 2026 at Mile End! To find out more and book your ticket, please follow this link: www.qmul.ac.uk/epigenetics/... The deadline to book your tickets is Monday, June 8th 2026.
@alison-harrod.bsky.social has her wonderful project on SMARCA4 and G quadruplex stability out now in Genome Biology link.springer.com/article/10.1...
New preprint from the lab! Our awesome @lillianwu.bsky.social drove this project with contributions from @kezlane.bsky.social @alison-harrod.bsky.social and collaborators @andrea-musacchio.bsky.social @chromatinlab.bsky.social and @claudioalfieri.bsky.social #CENP-B www.biorxiv.org/content/10.6...
biorxiv.org
The little one heading back to Uni after Easter break. (When does this get easier? 💔)
Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social
Karen Lane@kezlane.bsky.social · 10mo agoSome Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!
Some Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!
Boundary issues: SWI/SNF shapes chromatin patterns in and around centromeres
Abstract. The SWI/SNF family of chromatin remodelling complexes, comprising BAF, PBAF and ncBAF, is known for their critical roles in regulating chromatin
royalsocietypublishing.org
My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT). Informal enquiries to r.a.broderick@bham.ac.uk APPLICATION LINK: sits.bham.ac.uk/urd/sits.urd...
IPP login screen
sits.bham.ac.uk
The amazing @lillianwu.bsky.social is now the amazing Dr Lillian Wu 🎉 She passed her viva with flying colours. Massive thanks to her wonderful examiners @esashilab.bsky.social and @viji-draviam.bsky.social
Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
jobs.ac.uk
#Jobalert 🚨: Please RT ! Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism: How do (nuclear) metabolic enzymes reguate chromatin function ? #epigenomics, #epigenetics, #metabolism www.helmholtz-munich.de/en/ife/job-o...
Are you interested in working on related projects? 🌱 The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position. Apply here: www.hubrecht.eu/jobs
hubrecht.eu
@puckknipscheer.bsky.social · last yr.Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇 www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
imperial.ac.uk
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
imperial.ac.uk
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs www.cell.com/cell-reports...
ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
The ARID1A subunit of the BAF chromatin remodeling complex is frequently mutated in cancer. Simões-Sousa et al. demonstrate that ARID1A promotes the assembly of repair factors on chromatin and promote...
cell.com
The Downs Lab@thedownslab.bsky.social · last yr.New preprint from the lab on ARID1A, G quadruplexes, and repair: www.biorxiv.org/content/10.1...
Beautiful #pyrenees 😍. Totally refreshed and decompressed. Wonder how long that will last....
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum www.helmholtz-munich.de/en/stem-cell... Peer-networking / Career orientation and more !!! Please distribute :) 🙂
Epigenetics at Helmholtz Munich@epihmgu.bsky.social · last yr.🎤 Postdocs: want to take the next step and become a #PI? Apply to speak at the TALENT FORUM @www.helmholtz-munich.de, showcase your research in Epigenetics & Nucleic Acids, and connect with top scientists. 🧳 Travel & accommodation covered if selected! 📝 Apply by 31July. 🔗 Info: lnkd.in/drkRvz7N
New preprint from the lab on ARID1A, G quadruplexes, and repair: www.biorxiv.org/content/10.1...
ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...
biorxiv.org
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms Please forward to prospective students! Thank you url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex
At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.
url.uk.m.mimecastprotect.com
A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
tinyurl.com
We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025
Senior Research Officer at University of Essex
Searching for an academic job? Explore this Senior Research Officer opening on jobs.ac.uk! Click to view more details and browse other academic jobs.
jobs.ac.uk
