Federica Danzi, PhD
@federicadanzi.bsky.social
Postdoc in Donadelli Lab @University of Verona studying pancreatic cancer | p53 | HMGA1 | secretome | cancer metabolism
Back from two great days at the 6th Workshop of the #SIB #BiochimicaDeiTumori! It was a great opportunity to connect with colleagues doing exciting cancer research while presenting my poster! A huge shout-out to Maria Poles for winning the Best Poster Award! 🏆🎉 Congrats Maria! So well deserved!💪🏻
New study from the lab 🧵 1/ Pancreatic cancer is metabolically rewired and immunosuppressive. We asked: can targeting metabolism trigger immunogenic cell death (ICD) to boost anti-tumor immunity? Key twist: ferroptosis shows ICD signals in vitro, but is largely tumor-protective in vivo rdcu.be/fc55T
🚨New @lyssiotislab.bsky.social paper led by @radykm.bsky.social in @NatureMetabolism "NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions" 🧵Follow for a tweetorial... and bonus highlight of Vousden Lab co-published study and News & Views link from Wellen Lab!
Sweet weekend for a great cause! 🍫💙 Happy to have joined AIRC’s Chocolate for Research and supported cancer research🔬 @chiaramortali.bsky.social
Thanks Federica and congratulations once again! 🥳
Federica Danzi, PhD@federicadanzi.bsky.social · 9mo agoBack from the 37th AICC International Meeting in Florence 🇮🇹! Honored to present my work and receive the Best Oral Presentation Award 🏆 Huge thanks to the organizers, especially @andreamorandi.bsky.social and his team, for their support and for such an inspiring event! 🤩
Back from the 37th AICC International Meeting in Florence 🇮🇹! Honored to present my work and receive the Best Oral Presentation Award 🏆 Huge thanks to the organizers, especially @andreamorandi.bsky.social and his team, for their support and for such an inspiring event! 🤩
IT'S OUT! I invite you to read this amazing and important work!! Congratulation @federicadanzi.bsky.social !!! 💪💪💪
Federica Danzi, PhD@federicadanzi.bsky.social · 9mo agoExcited to finally share my PhD work! Huge thanks to my amazing collaborators and especially to my mentors for their guidance, support, and inspiration along the way: Massimo Donadelli, Alessandra Fiore and @lyssiotislab.bsky.social 🙏✨ www.nature.com/articles/s41...
Excited to finally share my PhD work! Huge thanks to my amazing collaborators and especially to my mentors for their guidance, support, and inspiration along the way: Massimo Donadelli, Alessandra Fiore and @lyssiotislab.bsky.social 🙏✨ www.nature.com/articles/s41...
Chemotherapy enhances HMGA1 secretion through the mutant p53-CK2 axis in pancreatic ductal adenocarcinoma cells - Cell Death & Disease
Cell Death & Disease - Chemotherapy enhances HMGA1 secretion through the mutant p53-CK2 axis in pancreatic ductal adenocarcinoma cells
nature.com
Excited to share a new story from the Lab! 🚨🩸 🧵 1/ Aspartate transaminases control blood development, by Narges Pourmandi, et al www.biorxiv.org/content/10.1...
Aspartate transaminases are required for blood development
Red blood cells (RBCs) have a limited lifespan of approximately 120 days. This necessitates continuous RBC production, resulting in ∼200 billion new RBCs made per day to maintain oxygen delivery. Desp...
biorxiv.org
New publication out! Proud to be part of this work exploring fatty pancreas disease from a multi-disciplinary perspective and to contribute to a growing field. www.sciencedirect.com/science/arti...
Fatty pancreas disease: an integrated study on frozen tissues shows distinct compartments of inter/intra-lobular, intra-acinar, and intra-islet fat deposition
Obesity-related diseases and perturbations of fat metabolism represent some of the most common health challenges. In this complex scenario, recent evi…
sciencedirect.com
Thrilled to share our latest work from the lab! Huge congrats to Maria, Raffaella & @chiaramortali.bsky.social for leading our new paper! 👉 doi.org/10.1111/febs...
FEBS Press
The TP53 tumor suppressor gene is frequently mutated in pancreatic ductal adenocarcinoma (PDAC). We focused on mitochondria and found that mutant p53 promoted MYH14 expression and mitochondrial fragm...
doi.org
I'm excited to share the lab’s new paper on PDAC-associated cachexia on bioRxiv today, led by star postdoc @nikitab.bsky.social “Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis” A 🧵 below, if you are interested... www.biorxiv.org/content/10.1...
Supporting cancer research with the Azalea by AIRC today!🌸
Congrats to @djcalebc.bsky.social and @lyssiotislab.bsky.social for this awesome work🤩 www.nature.com/articles/s41...
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer - Nature
A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.
nature.com
www.nature.com/articles/s41... Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer Congrats @anirbanmaitra.bsky.social!!
Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer - Nature
Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation i...
nature.com
Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis
Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…
sciencedirect.com
An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells. www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
science.org
ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al. Read it for free until March 19th at: authors.elsevier.com/a/1kWLq3jDgW...
🚨New paper dropped from Zeribe (now @NwosuLab) @PascaLab, @LyssiotisLb in @JCI_insight insight.jci.org/articles/vie...
Tremendous resource paper from NCI-PSRC member Nina Steele on collating a single cell RNA SEQ dataset in #PancreaticCancer The dataset is now housed with the PSRC. aacrjournals.org/clincancerre...
Our new preprint is now online! Here we describe in detail our strategy to isolate bacteria and fungi from pancreatic cancer patients. We also characterized a newly isolated Klebsiella oxytoca strain (UMKO1) in more detail. Thank you to all the co-authors and mentors! @lyssiotislab.bsky.social
bioRxivpreprint@biorxivpreprint.bsky.social · 2y agoIsolation and characterization of microbiota from human pancreatic tumors and small intestine https://www.biorxiv.org/content/10.1101/2024.11.27.625762v1
Selective metabolic regulations by p53 mutant variants in pancreatic cancer 🧪 Congrats @ivanoamelio.bsky.social & team jeccr.biomedcentral.com/articles/10....
Selective metabolic regulations by p53 mutant variants in pancreatic cancer - Journal of Experimental & Clinical Cancer Research
Background Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effect...
jeccr.biomedcentral.com