Bahne Bahners
@bahnebahners.bsky.social
Research Fellow @ Brigham & Women‘s Hospital and Harvard Medical School interested in #DBS⚡️#MEG 🧲 #EEG 🧠 #Parkinson 🌷 @netstim.org https://scholar.google.com/citations?hl=de&user=GmeYFEcAAAAJ
Which way best defines the optimal deep brain stimulation target in #Parkinsons? x-y-z coordinates? sweet spots? fiber tracts? whole-brain networks? @patriciazvarova.bsky.social has just answered this question: All of them. New study out now in AoN: onlinelibrary.wiley.com/doi/epdf/10....
New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.
Revisiting the methodological foundation of lesion network mapping
Lesion network mapping (LNM) links focal brain lesions to distributed neural circuits by projecting lesion locations through a normative functional connectome. van den Heuvel and colleagues recently s...
doi.org
A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...
Michael Fox@foxmdphd.bsky.social · 7mo agoA recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...
Netstim on route to the DBS summit in Würzburg! Looking forward to seeing everybody soon!
For the first time, we characterized the Parkinson's Disease Response Network across space and time, simultaneously. Fantastic work led by @bahnebahners.bsky.social out in BRAIN now 👇👇
Andreas Horn@andreashorn.org · 7mo agoNew @netstim.org publication alert: @bahnebahners.bsky.social in BRAIN out now: academic.oup.com/brain/advanc... A 🧵:
Researchers report the identification of "a deep brain stimulation response network that resembles the previously defined MRI network & operates in the high beta band"; Maximal connectivity to this network was associated with optimal DBS outcomes academic.oup.com/brain/advanc...
The deep brain stimulation response network in Parkinson’s disease operates in the high beta band
Bahners et al. identify a brain network linked to optimal therapeutic outcomes in patients with Parkinson’s disease receiving deep brain stimulation. This
academic.oup.com
🧠 Deep brain stimulation for Parkinson’s disease achieves its best results when a precisely defined brain network operating in the high beta frequency range is targeted. This was shown by a team @andreashorn.org @bahnebahners.bsky.social in both space and time for the first time.👇 uni.koeln/5LYV7
🧠 Die Tiefe Hirnstimulation bei Parkinson zeigt ihre bestmögliche Wirkung, wenn ein präzises Gehirnnetzwerk im Beta-Frequenzbereich (20–35 Hz) stimuliert wird – das zeigt ein Team um @andreashorn.org @bahnebahners.bsky.social jetzt erstmals gleichzeitig räumlich und zeitlich👇 youtu.be/ZrREFuDI-as
🚨 New research alert: What happens at the cortex during pallidal #DBS in patients with cervical #dystonia? 🧠 ⚡ ---> www.researchgate.net/publication/... <-----
Interpreting EEG requires understanding how the skull smears electrical fields as they propagate from the cortex. I made a browser-based simulator for my EEG class to visualize how dipole depth/orientation change the topomap. dbrang.github.io/EEG-Dipole-D... Github page: github.com/dbrang/EEG-D...
Can Christmas calm the Parkinson's brain? Feldmann, Neumann colleagues describe in a paper in Movement Disorders how Christmas alters brain signals recorded from deep brain stimulation systems in the setting of Parkinson’s disease. @parkinsondotorg.bsky.social #christmas #xmas
Looking forward to reading this paper (see thread). 👀 #neuroskyence
Ben Hayden@benhayden.bsky.social · 9mo agoThe organization of function is mostly determined by anatomical connectivity, but that’s quite different from cytoarchitecture, which is how Brodmann areas are defined. Connectivity-defined areas probably don't have compact blobby shapes, and are definitely patchy.
**Rethinking the centrality of brain areas in understanding functional organization** New paper I anticipate will become a classic in neuroscience and a must-read for students at all levels. Understanding brain function beyond brain areas. #neuroskyence www.nature.com/articles/s41...
What is the status of DBS for epilepsy? Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/ A 🧵 — please RT for reach! 🙏
🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com 🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals. www.nature.com/articles/s41... Join us: penglab.de
Longitudinal Changes in Cortical Response Dynamics with Deep Brain Stimulation to the Subcallosal Cingulate for Treatment-Resistant Depression https://www.biorxiv.org/content/10.1101/2025.11.26.690543v1
Long-term adaptive deep brain stimulation (aDBS) provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving continuous DBS. ja.ma/3M2ENGl
New paper out in npj Digital Medicine! Fayed Rassoulou demonstrates how electrophysiology + machine learning can help identify the optimal contact for deep brain stimulation. rdcu.be/eNgG1
Electrophysiological signatures predict the therapeutic window of deep brain stimulation electrode contacts
npj Digital Medicine - Electrophysiological signatures predict the therapeutic window of deep brain stimulation electrode contacts
rdcu.be
📈🧠 We're looking for brains! 🧠📈 Postdoc + PhD positions are available to help pioneer fetal MEG with optically pumped magnetometers, measuring prenatal responses to sound and light to understand how we start making sense of the world even before we're born. 🐣 Please get in touch to hear more!
There's still time to apply! #neurojobs
Decision, Action, and Neural Computation (DANC) lab@danclab.bsky.social · last yr.🚨Postdoc job offer🚨 Are you interested in beta bursts? Want to help drive methods for laminar inference with MEG? Now hiring a postdoc: run head-cast MEG experiments, help build our laMEG toolbox, and collaborate across Lyon–Marseille–Strasbourg. emploi.cnrs.fr/Offres/CDD/U... Please repost! 🧠📈
🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover! 🔗 Full article: onlinelibrary.wiley.com/doi/full/10.... @childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review
Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...
onlinelibrary.wiley.com
Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions shorturl.at/5Atjh
Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo
Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe
shorturl.at
My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!
Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.
Big thanks to @patriciazvarova.bsky.social and @bahnebahners.bsky.social for their wonderful contributions, and to @andreashorn.org for his mentorship on this project! Read the full study here: onlinelibrary.wiley.com/doi/10.1002/...
Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?
Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P....
onlinelibrary.wiley.com
🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--
Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
This is amazing work!
Frederic Schaper@fredschaper.bsky.social · 2y agoIs generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:
