Excited to share that my main PhD work with @labsalta.bsky.social is now out in @cp-cellstemcell.bsky.social ✨ — with lots of new additions! Feeling very grateful for all the teamwork and everyone who contributed along the way 💜 www.cell.com/cell-stem-ce...

Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience

Tosoni and colleagues identify immature neurons in the aged human hippocampus with signatures of younger biological age and cellular fitness. Their molecular programs and intercellular interactions ar...

cell.com

Giorgia Tosoni@giorgitos.bsky.social · 2y ago

🧵 1/ Excited to share our new research on immature neurons (ImN) in the adult human brain and their roles in healthy aging, Alzheimer’s disease (AD), and cognitive resilience. Here’s what we discovered 👇

Looking forward to trying this out!!

Will Macnair@willmacnair.bsky.social · 5mo ago

New preprint! Our workflow for processing single cell and nuclei data, called 🎉 scprocess 🎉 We have been working on it for ~18 months now, over which time we have processed at least 2k samples with it, so it has had a decent amount of testing.

Adult neurogenesis: New neurons, new opportunities

Adult neurogenesis: New neurons, new opportunities

Kempermann and colleagues discuss new directions in neuroscience stemming from an understanding that adult neurogenesis contributes to brain function in health and disease. They discuss the role and function of adult stem cells; the impact of environmental regulation; the interplay between development, plasticity, and aging; and other fundamental questions.

dlvr.it

Huntington’s disease is the best investment in neuroscience today www.sciencedirect.com/science/arti... #Huntingtons #Neuroscience #Investment

Huntington’s disease is the best investment in neuroscience today

Huntington’s disease (HD) is usually described as rare, tragic, and intractable. Yet, HD offers a strategically unique entry point for neuroscience. W…

sciencedirect.com

#MSCA success rates now below 10%, yet the work that goes into writing this application is immense. Beyond the obvious increase in funding we need to find ways to lighten the time investment as well. Thousands of researchers spend weeks if not months working on this.

José Cerca@naturalselection.bsky.social · 6mo ago

Let's look at some numbers 2022: 7 044 applications submitted. 17.9 % success rate 2023: 8 039 applications submitted. 15.8 % success rate 2024: 10 360 applications submitted. 16.6 % success rate 2025: 17 058 applications submitted (record high). 9.7% success rate (preliminary numbers).

Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...

tinyurl.com

For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠 www.nature.com/articles/s41...

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience

The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

nature.com

Why do some people with Alzheimer’s do not show symptoms of Alzheimer's? During her PhD, @giorgitos.bsky.social explored this question. Part of the answer led her to an unexpected group of brain cells: underdeveloped neurons. Read the full article on our website: nin.nl/news/the-eld...

The elderly brain is less mature than you think and that could protect you from Alzheimer’s Disease - Netherlands Institute for Neuroscience - Master the Mind

nin.nl

Important perspective on a fascinating study from the Frisén group, which used machine learning to identify neural progenitors in the adult human brain, a fresh lens on a long-standing debate 💥 Always exciting to see this field evolve, and grateful to be part of it @labsalta.bsky.social

The Transmitter @thetransmitter.bsky.social · last yr.

Single-nuclei RNA sequencing combined with machine learning provides a way to identify neural progenitor cells in the adult hippocampus, a new study suggests. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/neurogenesis...

Hora est 🎓 Last Thursday, I defended my PhD at the University of Amsterdam, @nin-knaw.bsky.social—graduated cum laude ✨ Huge thanks to my amazing supervisor @labsalta.bsky.social, co-promoters Paul Lucassen, Inge Huitinga & @fitzsimonslab.bsky.social. Thanks to all who made the day unforgettable!

I'm proud of contributing to @nkrauth.bsky.social @clemmensenc.bsky.social @olekiehn.bsky.social discovery of the role of an hypothalamic-brainstem circuit for prioritization of safety. Really impressive amount of work led by @nkrauth.bsky.social

Nathalie Krauth@nkrauth.bsky.social · last yr.

Honored to share that our paper is out today in Nature Neuroscience: www.nature.com/articles/s41... We identify a hypothalamic-brainstem circuit linking internal states to locomotion: These projections drive safety-focused movement over competing behavior. #Neuroscience #Hypothalamus #Locomotion

@labsalta.bsky.social identified persistent populations of immature neurons that were associated with ‘juvenile’ cellular functions, suggesting that these immature populations may actively contribute to maintaining homeostasis within the aged human hippocampus. www.biorxiv.org/content/10.1...

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience

The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have high...

biorxiv.org

Our paper has sparked a lot of people asking me – so Keri, what’s the tldr – is there, or isn’t there, new neurons in the human hippocampus? It's a little more complicated than a yes or no IMO.

Keri Martinowich@martinowk.bsky.social · last yr.

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published. www.cell.com/cell-reports...

Excited to share our preprint led by Ain Chung & @jasonalipio.bsky.social showing how immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n www.biorxiv.org/content/10.1...

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published. www.cell.com/cell-reports...

Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...

Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans

Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...

biorxiv.org

I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz

The NINclusion team launched the NIN Gym to support mental and physical health within the institute. Over the next 10 weeks, employees can join alternating Yoga and Bootcamp sessions led by personal trainer Ties (@tiesverbeekpt.bsky.social) on Thursdays. The first session took place last week! 💪

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

🧵 1/ Excited to share our new research on immature neurons (ImN) in the adult human brain and their roles in healthy aging, Alzheimer’s disease (AD), and cognitive resilience. Here’s what we discovered 👇

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y ago

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer's disease, and cognitive resilience https://www.biorxiv.org/content/10.1101/2025.01.08.631686v1

Big achievement for the green office (and not only!), finally LEAF is implemented in our Institute @nin-knaw.bsky.social 💚

Netherlands Institute for Neuroscience (NIN)@nin-knaw.bsky.social · 2y ago

🌱 Exciting news from our green office! Two labs have joined the certified sustainability programme, LEAF. Congratulations to Evgenia Salta’s lab and the @socialbrainlab.bsky.social for earning the bronze award and making impactful strides toward environmentally friendly research practices. 🎉

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n

Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction link.springer.com/article/10.1...

Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction - Acta Neuropathologica

Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to contribute to cellular dysfunction in age-related disorders, including late-ons...

link.springer.com

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

Hello, (Bluesky 🦋) World! I’m Giorgia, and I’m new here. Wrapping up my PhD in the SaltaLab at the Netherlands Institute for Neuroscience. My research focuses on adult neurogenesis, Alzheimer's, and single-cell approaches. Check out our past work here: tinyurl.com/373x5r9z. Stay tuned for more!

Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate?

Tosoni et al. probe the challenges related to the design, analysis, and interpretation of single-cell transcriptomic studies in the adult human hippocampal neurogenic niche and propose a series of cri...

tinyurl.com

Anyone working with single nuclei data should read this paper! (single cell too, but for nuclei data it's essential) If I could only have one QC metric for single nuclei data, it would be spliced pct / intronic fraction (I think it's more useful even than number of UMIs 🤯). #SingleCell

Tomàs Montserrat Ayuso@tmontsay.bsky.social · 2y ago

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8