The dark horse of biology: how RNA is becoming a nanotool maker’s dream

Scientists are harnessing its ability to fold, switch and reorganize itself to create a new generation of cellular technologies.

nature.com

Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

nature.com

Biotech’s coming of age - Nature Biotechnology

Biotech is back. But continued investor caution, the rise of China and fast-moving AI are changing the sector’s contours.

nature.com

The broader sense of nonsense

The term ‘nonsense-mediated mRNA decay’ (NMD) was initially coined to describe the translation-dependent degradation of mRNAs harboring premature termination codons (PTCs), but it is meanwhile known t...

cell.com

The long-lived immune system of centenarians

Nature Reviews Immunology, Published online: 23 April 2026; doi:10.1038/s41577-026-01291-5What is unique about the immune system of people who live to extreme old age? Here the authors describe that centenarians may achieve such longevity through several mechanisms, including limiting the pathological effects of inflammageing and immunosenescence, preservation of immune surveillance, sustained gut microbial diversity and maintenance of intestinal barrier integrity.

dlvr.it

#hdgratitudeday #huntingtonsdisease #raredisease | Inverna Therapeutics

Today, on Huntington’s Disease Gratitude Day, we honor the strength and commitment of the HD community. We recognize the collective progress made through collaboration and the shared foundation it cr...

linkedin.com

Thymus health is a predictor of lifelong well-being and immunotherapy effectiveness

It was thought that the thymus serves its purpose for the immune system early in life. Insights about the organ in adults reveal its importance for later well-being.

nature.com

#rnatherapeutics #pseudoexons #rnaleaders #precisionmedicine | Poul Sørensen

I’m looking forward to speaking at RNA Leaders Europe 2026 in Vienna March 17-19 🧬 At Inverna Therapeutics we are developing precision RNA therapeutics that activate disease-relevant pseudo-exons wi...

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Immune reset and immune retune: approaching cure? - Nature Reviews Rheumatology

The emergence of potent depletion therapies for the treatment of refractory autoimmunity has led to the concept of immune reset. Understanding whether immune reset equates to cure, and whether cure is...

nature.com

Huntington’s disease is the best investment in neuroscience today

Huntington’s disease (HD) is usually described as rare, tragic, and intractable. Yet, HD offers a strategically unique entry point for neuroscience. W…

sciencedirect.com

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

science.org

A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice

A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

science.org

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress | Nature Neuroscience

Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged healthy donors directly into neurons, which retained their aging hallmarks, and we verified key findings in aged human and mouse brain tissue. Here we show that aged neurons are broadly depleted of RNA-binding proteins, especially spliceosome components. Intriguingly, splicing proteins—like the dementia- and ALS-associated protein TDP-43—mislocalize to the cytoplasm in aged neurons, which leads to widespread alternative splicing. Cytoplasmic spliceosome components are typically recruited to stress granules, but aged neurons suffer from chronic cellular stress that prevents this sequestration. We link chronic stress to the malfunctioning ubiquitylation machinery, poor HSP90α chaperone activity and the fai

doi.org

Women have supercharged immune systems and we now know why

Being born with two X chromosomes brings a host of health benefits, and recognising this could lead to personalised medical treatments for men and women

newscientist.com

Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions - Nature Reviews Gastroenterology & Hepatology | Elena Kotsiliti

As immune tolerance is trending now, have a look at this Review on 'Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions' by Ludvig M. Sollid that was published...

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Novel Novartis Malaria Drug Shows Promise to Become New Asset Against Resistant Strains

Phase 3 results for the Novartis malaria drug “GanLum” show it was comparable to the standard of care and led to cure rates that top the threshold recommended by the World Health Organization. If approved, this new combination drug would become the first novel malaria therapy in more than 25 years.

medcitynews.com

Aarhus Immunotherapy Symposia

conferences.au.dk

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

go.nature.com

Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris

Functionally stable regulatory T cells converted in vitro from pathogenic T cells can confer antigen-specific immunosuppression in pemphigus vulgaris.

science.org

Inverna Therapeutics announces the formation of its Scientific Advisory Board consisting of world-renowned leaders in RNA therapeutics and neurodegenerative research | Inverna Therapeutics

Inverna Therapeutics is delighted to announce the formation of our new Scientific Advisory Board (SAB)🚀 We welcome world-renowned leaders in RNA therapeutics and neurodegenerative research to advance...

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