Dear microbiome enthusiasts: I'm excited to be moving my lab to New York University this fall (& the NYU Institute for Engineering Health); with joint-appointment @isbscience.org I'm hiring a postdoc @ NYU to look at diet-driven evolution in the gut: apply.interfolio.com/189980 Please share! 🦠🤓

Inference of secreted protein signaling activities in intercellular communication www.nature.com/articles/s4...

Me as I continue to write NIH grants like it is 1999

Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndrome @natcomms.nature.com www.nature.com/articles/s41... @weillcornell.bsky.social

If you're registering for the @cytokinesociety.bsky.social meeting, don't forget to also register to our ifnlworkshop.org held for #free on the 22nd of October.

International Cytokine & Interferon Society (ICIS)@cytokinesociety.bsky.social · 8mo ago

Cytokines 2026 in Glasgow (Oct 18-21) has an incredible Scientific Organizing Committee! Simon Jones, Iain McInnes, Clare Bryant, Clare Lloyd, and Luke O'Neill creating the program. This one's going to be special. Details: 2026.cytokinesociety.org

Our new manuscript, by lead author Gargi Mishra, shows that the IFN-I locus in pDCs is poised for rapid interferon production, as PU.1 and IRF8 establish an open chromatin architecture. #Immunology #Interferons #InnateImmunity #Epigenetics

Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells

Plasmacytoid dendritic cells (pDCs) produce robust type I interferons (IFN-I) within hours of viral sensing, while epithelial cells at mucosal surfaces mount a delayed response dominated by type III i...

urldefense.com

Review @sciimmunology.bsky.social @slg1717.bsky.social Tissue-specific roles and downstream signal transduction mechanisms of IL-17 www.science.org/doi/10.1126/...

The tissue-specific regulation of immunobiology by IL-17 signaling

The tissue-specific roles and downstream signal transduction mechanisms of IL-17 in immunobiology are reviewed.

science.org

Two more alumni for the acknowledgment slide. Omkar and Morgan you will be missed!

We are hiring @umichmicroimmuno.bsky.social ! Tenure-track assistant professor position in our Microbiology and Immunology department. We are especially looking for someone working in bacterial pathogenesis

Thrilled to share the first paper from the lab, out now in Molecular Cell! A wonderful collaboration with @thurstonlab.bsky.social bridging Salmonella host-pathogen interactions and regulatory genomics - two of my favourite things in one story. www.cell.com/molecular-ce... 🦠 🧵1/10

Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

Diaz-del-Olmo et al. reveal how a Salmonella virulence protein alters the transcriptional layout of infected macrophages through hyperactivation of a transcription factor and coordinated chromatin rem...

cell.com

New research published in @natimmunol.nature.com by @poholeklab.bsky.social shows how the transcription factor BLIMP1 controls the identity of cells involved in allergic asthma in mice. Read more: www.immunology.pitt.edu/news/blimp1-...

Excited to share our paper out today in @science.org! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4) www.science.org/doi/10.1126/...

Disordered protein LAT encodes relative levels of signaling pathways in T cell activation

The disordered adapter protein linker for activation of T cells (LAT) propagates T cell receptor signaling. To interrogate how LAT coordinates multiple downstream pathways, we developed a single-cell ...

science.org

Introducing our new staff spotlight section! Meet Omkar Betsur, a research technician in @gottschalklab.bsky.social's lab, who is actually leaving us next month to start medical school at D'Youville University College of Medicine. Congrats, Omkar! 🩺 www.immunology.pitt.edu/news/staff-s...

#discovery from my lab @nature.com. Three isoforms of caspase-5, long known for #inflammation & #celldeath, exist in human #gut. CASP5C uniquely amplifies Wnt to nurse transit-amplifying cells supporting #homeostasis & #regeneration. Implications for #IBD & #CRC www.nature.com/articles/s41...

Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis - Nature

CASP5 expression is restricted to the human intestinal epithelium, and the CASP5C isoform has a key role in promoting Wnt signalling, which is required for epithelial homeostasis, through binding...

nature.com

New research published in @natimmunol.nature.com by Pitt Immunology researchers sheds light on how the immune system balances B cell quality and diversity during infection or after vaccination, offering a potential new avenue to improve vaccines. Learn more: www.immunology.pitt.edu/news/blimp1-...

Tomorrow (April 17) is a busy day for the Pitt Department of Immunology at the @aai.org #IMMUNOLOGY2026 meeting! Here’s where you’ll find us in the morning!

Go chat with Sonia Kruszelnicki about how microbiota-dependent IGF-1 shapes alveolar macrophage function. AAI, tomorrow morning!

Pitt Department of Immunology@pitt-immunology.bsky.social · 4mo ago

And posters at the morning session 11:30am-12:30pm

Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....

Excited for this! If you are in the area, would love to see you.

Samuel A. Myers' lab@samyers-lab.bsky.social · 4mo ago

Another great speaker @gottschalklab.bsky.social coming to @lji.org. Come join!

Good things come in threes! Please join us in congratulating @gottschalklab.bsky.social, @rh-lab.bsky.social, and @meisellab.bsky.social on promotion to associate professor! (1/2)

Excited to share that our paper was accepted at @insight.jci.org ! GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function insight.jci.org/articles/vie...

GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function @insight.jci.org @gottschalklab.bsky.social insight.jci.org/articles/vie...

New preprint! TL;DR: Network analysis reveals that CEBP/β and PU.1 stabilize regulatory architecture in tissue-resident alveolar macrophages to constrain inflammatory responses www.biorxiv.org/content/10.6...

TNF is a driver of rheumatoid arthritis, but the pathway details remain incomplete @SLG1717.bsky.social & team now report Arid5a as an activator of TNF signaling elevated in human RA tissues. And its loss in mice results in resistance to arthritis: doi.org/10.1172/jci....

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

Just quit

Quitting projects in science is hard, but we should be doing a lot more of it.

open.substack.com

Her training is almost complete

49 travel grants awarded! 🎉 These early-career scientists are going to absolutely crush it at Cytokines 2025. The future of cytokine biology is looking bright with talent like this! Check out all the recipients: cytokinesociety.org/2025/08/29/2... #CytokineSociety #Cytokines2025 #NextGenScientists

Do you know an undergrad at Pitt, Chatham University, or @cmu.edu who hasn't had opportunities for hands-on research? Please encourage them to apply for the Microbiology and Immunology Departments (MID) Scholars Program! Learn more and apply: lnkd.in/eT-gYTqR

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n facultypositions.stanford.edu/en-us/job/49...