Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

Very excited to share our newest findings! A very long team effort pursued by multiple team members -to frantically reproduce everything over and over-, we show mTOR-Polycomb synergy at promoters of developmental master regulator TFs in ESCs prior to their expression. www.biorxiv.org/content/10.6...

🚨The abstract submission deadline is this Friday 17 April 2026.

the Node@the-node.bsky.social · 4mo ago

Mark your calendars! The @lscn.bsky.social 9th Annual Symposium is happening on 15 May – and it's shaping up to be an unmissable day of cutting-edge science, collaboration, & community! A great line-up has also been announced. www.eventbrite.co.uk/e/9th-annual...

De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion www.nature.com/articles/s41...

De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion - Nature Genetics

The authors deplete the cohesin activator NIPBL during the mitosis-to-G1-phase transition. They observe that structural loop formation is impaired proportionally to loop length, while gene activation ...

nature.com

We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬🧬Looking forward to your application!✉️

Friends Davor Solter and Azim Surani receiving the wonderful Paul Ehrlich and Ludwig Darmstaedter Prize for Genomic Imprinting👏 👍 @Frankfurt Germany. With official talks from politicians using words like Education, Knowledge, Democracy 🙏 @maxplanck.de @gurdoninstitute.bsky.social

Enhancers are genetic regions that promote the activation of neighbouring genes. @radaiglesiaslab.bsky.social asks how long-range enhancers maintain specificity by constructing synthetic gene landscapes and exploring how they affect gene activity. #gfe2026 Alvaro's @dev-journal.bsky.social Review⤵

Enhancer-gene specificity in development and disease

Summary: This Review discusses recent insights into the factors controlling enhancer specificity and how this might help us understand the genetic basis of human disease.

doi.org

Great to see this work out from our neighbours @mrc-lms.bsky.social driven by Noura Maziak @vaquerizasjm.bsky.social! With Pico-C they reveal a modular regulatory logic driving genome establishment - congrats to all authors!

Noura Maziak@nmaziak.bsky.social · 6mo ago

Excited to share my PhD work! The question: How is genome organization established? Here, we developed a low-input Micro-C method, Pico-C, and used it to map chromatin architecture across early stages of fly development. Here’s a quick Blue-torial 🙂 (1/n) www.nature.com/articles/s41...

📢Magda Koziol @epigenome.bsky.social will be speaking at the DPZ @primatenzentrum.bsky.social in Göttingen this Wednesday. 🗓️11 March ⏰13:00 Join us for an exciting seminar! 👇👇

Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: academic.oup.com/nar/article/... A huge effort to pull together what we’ve learned about nucleosome spacing in many systems. Enjoy! @milena-bikova.bsky.social @chrsclrksn.bsky.social

Considerations for the future of in vitro gametogenesis in fertility care - @hannahlandecker.bsky.social @uclacrshe.bsky.social @uclamcdb.bsky.social @uclastemcell.bsky.social go.nature.com/4l2e9en

Institut Pasteur (@pasteur.fr) is recruiting new young PIs to open new groups in the Institute. Deadline is February 9th! Don't miss the opportunity!

Deadline TODAY January 23 - please join the Systems Biology: Global Regulation of Gene Expression meeting in beautiful @cshlnews.bsky.social (March 11-14). Register and submit your abstract here: meetings.cshl.edu/meetings.asp.... Please Repost!

Systems Biology: Global Regulation of Gene Expression

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

Do not miss this great symposium in Utrecht! Stellar speakers, free registration and fun audience in a great institute!! 🤩 Registration is open now

Hubrecht Institute@hubrechtinstitute.bsky.social · 8mo ago

Register now for the second Hubrecht Symposium, themed Molecular Machines in Development in Utrecht on March 26, 2026. Visit hubrecht.eu/hubrecht-symposium-2026/ for registration and abstract submission. Abstract submission deadline: February 1, 2026.

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

An integrated view of the structure and function of the human 4D nucleome - Nature

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

nature.com

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...

Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology

Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

nature.com

We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists. The piece is available open access in Nature Communications: www.nature.com/articles/s41...

Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

nature.com

Want to shape the future of genome science? 🧬 PhD positions available at Max Planck Institute & Uni Göttingen (IMPRS-GS/GönomiX)! Join a vibrant, interdisciplinary research community. Apply by Jan 14, 2026: www.uni-goettingen.de/de/applicati... #GenomeScience #Research

We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉 Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠

Our latest paper on comparative analysis of HiChIP data is now online! HiChIP is one of the most useful/practical assays to profile 3D genome organization and chromatin loops but has its challenges in the data analysis especially when it comes to comparative analysis.

🚨 Exciting conference for stem cell aficionados! ‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling. fisci2026.eventbrite.co.uk Please repost 🙏

Frontiers in Stem Cell Innovation 2026

Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery

fisci2026.eventbrite.co.uk

Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....

New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here: www.biorxiv.org/content/10.1... 👇 1/

Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.

Most read, I hear! Here is your chance to read what @mariekeoudelaar.bsky.social and I had in mind when writing this together.

Annual Reviews@annualreviews.bsky.social · 12mo ago

The latest Annual Review of Genomics and Human Genetics is now online 🧬 Most read article so far is "Mechanisms of Enhancer-Mediated Gene Activation in the Context of the 3D Genome" @akispapantonis.bsky.social @mariekeoudelaar.bsky.social Check it out arevie.ws/47BZEJp Full TOC: arevie.ws/4plCaPe

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

So, we (Dylan Liabeuf and Anastasiia Maksiuk) are organising the first Berlin symposium on organoids. The objective is to bring together the Berlin organoid community and to develop further interactions. Info: www.bihealth.org/en/notices/b... Free registration: www.bihealth.org/en/news/even...

Berlin Organoid Symposium - News - BIH at Charité

The Berlin Organoid Symposium will highlight recent advances in the field, covering topics from fundamental organoid biology to translational applications. By uniting scientists from various instituti...

bihealth.org

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells www.cell.com/developmenta...

Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm

Correct patterning of emerging tissues in the developing embryo is essential for the formation of functional organ systems. Using genetic tools for controlled protein depletion, Ee et al. identify the...

cell.com

Great honor to be nominated as one of the top 10 Falling Walls Foundation Science Breakthroughs of the Year 2025 in the Life Sciences. A big thank you to @ovarylab.bsky.social & @tabeamarx.bsky.social for their outstanding contributions, & to everyone else who helped move this project forward.

MPI for Multidisciplinary Sciences@mpi-nat.bsky.social · last yr.

Keeping our fingers crossed for you, Melina @schuhlab.bsky.social! We are thrilled that our director has been nominated for the Falling Walls Foundation Science Breakthroughs of the Year 2025 in the Life Sciences category with her project “Breaking the Wall of Invisible Ovulation”. 🥂