Harihar Mohan
@harimohan.bsky.social
Postdoc in the Parker lab at HHMI/CU Boulder 🦬. Studying RNA processes in repeat expansion disorders. PhD from UMich 〽️. He/him, views are mine, proud immigrant from India 🇮🇳
Our paper discovering novel roles for the retrovirus-like proteins RTL8 and PEG10 in shaping stress granule biology is now online on Science Advances! #llps #stressgranules www.science.org/doi/full/10....
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
Virus-like proteins help our cells respond to environmental stress.
science.org
Earlier this month, I defended my PhD in front of friends and family. As a teenager, I dreamed of this moment and I’m glad it finally came true. Thanks to my mentors, Drs. Paulson and Sharkey and my committee members! I will be starting a postdoctoral position in Dr. Roy Parker’s lab at CU Boulder.
Wow, really stunning pictures!
Ricardo Henriques@henriqueslab.bsky.social · last yr.🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors pubs.aip.org/aip/apr/arti...
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically connecting ‘cell surface RNA biology’ to cancer biology @natbiotech.nature.com www.nature.com/articles/s41...
Mismatch repair inhibitors lift off in Huntington’s www.nature.com/articles/s41...
Mismatch repair inhibitors lift off in Huntington’s - Nature Biotechnology
Startups targeting DNA repair seek to build on recent findings that neurodegeneration in Huntington’s disease is triggered only after CAG triplet repeats reach a critical threshold.
nature.com
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv
Really cool finding about how VCP protects against bacterial pathogens…
Nature Microbiology@natmicrobiol.nature.com · last yr.🚨 Out now: A new study showing that VCP/p97 extracts ubiquinated proteins from bacterial membranes to lyse and kill intracellular bacterial pathogens #MicroSky 🦠 www.nature.com/articles/s41...
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
nature.com
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers https://www.biorxiv.org/content/10.1101/2025.04.07.647611v1
Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...
Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome https://go.nature.com/4iECjJz
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistance mechanisms and shows no toxicity towards human cells.
go.nature.com
Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...
cell.com
If you have a federal grant, I *highly* recommend going to this Friday's webinar on responding to grant terminations. Lisa Brown, former general counsel at Dept of Ed, will present along with other lawyers. Friday, March 21, 2-3 pm. More info & register here: www.linkedin.com/pulse/regist...
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed
Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%
datawrapper.dwcdn.net
High-quality manuscripts complement scientific value and readability "Views and suggestions for young scientists and early-career researchers on how to prepare a high-quality manuscript." PDF: www.cell.com/action/showP...
This is going to be an important paper for years to come in the HD field! www.nature.com/articles/s41...
Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification - Nature Neuroscience
Nguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA modification and loc...
nature.com
I wonder if in the future we could take a CRISPRi pill along with penicillin to get rid of a UTI
Antimicrobial resistance #AMR@antimicrobial.bsky.social · 2y agoCRISPR is a gene-editing tool that uses RNA-guided enzymes to target specific DNA sequences. Italian researchers used CRISPR interference (CRISPRi), a non-cleaving version, to suppress ARGs in E. coli, restoring antibiotic effectiveness without causing mutations. 👍 www.nature.com/articles/s41...
Does anyone have suggestions on detecting viral particle formation in cells fluorescently?
One of the best pieces of advice to hear for basically everything is: the time will pass anyway. Whether it is transitioning, or a health goal, learning how to play music or make art or speak a language or whatever. No matter how long that'd take to do: that time will pass anyway
"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmap
E11 Bio Roadmap | E11 Bio
e11.bio
Woah, this has so many potential applications! www.nature.com/articles/s41...
Designing artificial fluorescent proteins and biosensors by genetically encoding molecular rotor-based amino acids - Nature Chemistry
The toolbox of artificial fluorescent proteins can be expanded by engineering mimics of the molecular rotor-based fluorophore found in the green fluorescent protein (GFP) into diverse protein scaffold...
nature.com
"Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations" www.pnas.org/doi/abs/10.1...
Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations | PNAS
Disparities continue to pose major challenges in various aspects of science. One such aspect is editorial board composition, which has been shown t...
pnas.org
This is such a useful tool to study mRNA localization across the whole brain at a single cell resolution. Can’t wait to see studies that use it to map where disease-specific transcripts localize to! www.science.org/doi/10.1126/...
Whole-brain spatial transcriptional analysis at cellular resolution
Recent advances in RNA analysis have deepened our understanding of cellular states in biological tissues. However, a substantial gap remains in integrating RNA expression data with spatial context acr...
science.org