Harsha Gouda
@harshagouda.bsky.social
Post-doc at Dorrestein lab. Interested in all things metabolism, microbes and enzymes.
🚨 I'm delighted to share that I'll be a funded through the Eric & Wendy Schmidt AI in Science Postdoctoral Fellowship! Excited to push the boundaries of ML in metabolomics for human health. Thank you to my mentor @pieterdorrestein.bsky.social and Dorrestein lab team!🚀
Where has this molecule been detected before across samples, organisms, body parts, and environments? With StructureMASST, you can explore this directly by entering a molecule name and running a search in your browser. 🔗 structure-masst.gnps2.org 📄 www.nature.com/articles/s41...
Streamlit
structure-masst.gnps2.org
Structure-centric searching enables global mapping of the public metabolome - @pieterdorrestein.bsky.social @mingxunwang.bsky.social @yelabiead.bsky.social go.nature.com/481Sbmk
Structure-centric searching enables global mapping of the public metabolome - Nature Biotechnology
StructureMASST enables pan-repository MS/MS searches using a chemical name or structure.
go.nature.com
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/interactive/...
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article)
A quiet policy change means the government is making fewer bets on long-term science.
nytimes.com
Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6
Get your paper reviewed before peer review at www.qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities #CurrOpinMicrobiol by @harshagouda.bsky.social et al from @pieterdorrestein.bsky.social www.sciencedirect.com/science/arti...
The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities
With the exception of molecules acquired through the lungs, skin absorption, or part of a medication regime, nearly all molecules in our bodies origin…
sciencedirect.com
The interactions between food, microbiome and host that modulate health can be complex. Here, we offer a perspective on how mass spectrometry can be leveraged to address some of these challenges to understand host and microbial metabolism of food. A step closer to personalized health and nutrition.
The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities
With the exception of molecules acquired through the lungs, skin absorption, or part of a medication regime, nearly all molecules in our bodies origin…
sciencedirect.com
Poster is made, printed and ready to go! Looking forward to my first mass-spec conference #ASMS2025 at Baltimore next week!
Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods https://go.nature.com/4kybHea
How much ultra-processed food do you eat? Blood and urine record it
Samples could provide an objective measure of diets and help to unravel their contribution to disease.
go.nature.com
New @science.org Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective www.science.org/doi/10.1126/...
Should you return home after earning your PhD abroad? This Nature article explores the dilemmas faced by international researchers considering a move back to their home countries. A thought-provoking read for anyone navigating global academic careers.  www.nature.com/articles/d41...
Should I return to my home country after my PhD abroad?
A graduate student from southeast Asia, now based in a European country and missing her homeland, agonizes over her next career move.
nature.com
QC:MXP version 2.0 is now available to download for free from my GitHub page: www.qcmxp.org Repeat-injection-based Quality Control, Batch Correction, Exploration & Data Cleaning. #Metabolomics #AnalyticalChemistry #Matlab
Individuals who were conceived in colder seasons are more likely to show higher brown adipose tissue activity, increased energy expenditure and a lower BMI, and lower fat accumulation around internal organs, suggests a study in Nature Metabolism. https://go.nature.com/4i3EYM0 🧪
New blog post! In which I explain the issue with mediation analysis and sketch out one way to deal with the underlying causal inference problem -- in just a bit over 1,000 words! If you have never found the time to read up on this, now is your chance. www.the100.ci/2025/03/20/r...
Reviewer notes: That’s a very nice mediation analysis you have there. It would be a shame if something happened to it.
Mediation analysis has gotten a lot of flak, including classic titles such as “Yes, but what’s the mechanism? (Don’t expect an easy answer)” (Bullock et al., 2010), “What mediation analysis can (not) ...
the100.ci
Event organizers often overlook the visa-related difficulties that researchers in low- and middle-income countries face. This must change, says Kara Hanson https://go.nature.com/3DioEc0
We moved a conference halfway around the globe to avoid visa discrimination
Event organizers often overlook the visa-related difficulties that researchers in low- and middle-income countries face. This must change.
go.nature.com
Discovery of metabolites prevails amid in-source fragmentation #NatMetab www.nature.com/articles/s42...
Discovery of metabolites prevails amid in-source fragmentation - Nature Metabolism
Nature Metabolism - Discovery of metabolites prevails amid in-source fragmentation
nature.com
Another fun paper that was started by a good and important question by Prajit - an undergrad in the lab - about imputation. We then teamed up with the Kelley lab as they are good at such benchmarking in data science. So fun to work woth them. pubs.acs.org/doi/10.1021/...
To Impute or Not To Impute in Untargeted Metabolomics─That is the Compositional Question
Untargeted metabolomics often produce large datasets with missing values. These missing values are derived from biological or technical factors and can undermine statistical analyses and lead to biase...
pubs.acs.org
The #InternationalSpaceStation is overly sterile; making it “dirtier” could improve astronaut health, microbiologists say. cell.com/cell/fulltex... Learn more in @cp-cell.bsky.social @pieterdorrestein.bsky.social, Rob Knight
The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns
With long-term space travel and extraterrestrial habitation becoming feasible, understanding how space environmental exposures, microbial communities, and molecular profiles differ from Earth is cruci...
cell.com
A new resource rating >50,000 foods from 3 grocery stores (Walmart, Target, and Whole Foods) for degree of processing and breakdown of ingredients www.nature.com/articles/s43... Website for consumers www.truefood.tech
Such a wonderful SIMB workshop on @gnps2.bsky.social covering classical mol networking, FBMN, ion identity based mol networking, FBMN-STATS, gnps-dashboard, CMMC-kb, Modifinder, MicrobeMASST, MassQL, and limited ReDU - many were covered at a workshop for the first time. 1/4
An accurate IDMS-based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean #JFoodSci ift.onlinelibrary.wiley.com/doi/10.1111/...
An accurate IDMS‐based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean
Abstract Phytohemagglutinin (PHA), a natural tetramer comprising PHA-E and PHA-L subunits that preferentially bind to red and white blood cells, respectively, constitutes a significant antinutrition...
ift.onlinelibrary.wiley.com
Welcome to the wonderful #mzmine @mzmine.bsky.social team in Bluesky @bsky.app . So nice to have you in #ICTC13 metabolomics workshop ! Check it out at www.ictc13.gr
New tensor factorization paper out today — a fun collaboration with Pixu Shi, Liat Shenhav, Rob Knight, & Anru_Zhang! 🎉 Check it out here: genomebiology.biomedcentral.com/articles/10....
TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies - Genome Biology
Longitudinal studies are crucial for understanding complex microbiome dynamics and their link to health. We introduce TEMPoral TEnsor Decomposition (TEMPTED), a time-informed dimensionality reduction ...
genomebiology.biomedcentral.com
I’m starting to fall in love with math again. It was enzyme kinetics in grad school, now it’s testing different models on clinical data.
What if I told you that if you have coyote "problems" (as in, you feel there are too many), killing them...can make it WORSE? Me on @rolandkays.com 's latest paper, so glad his lab is studying this! teamtrash.substack.com/p/hunt-more-...
Hunt more coyote, get more coyote
Humans often assume killing will solve the problem. Here's yet another example of why we are wrong.
teamtrash.substack.com
