A “precision guided” CAR T-cell therapy designed at Peter Mac to kill solid tumours will progress to a first-in-human clinical trial thanks to almost $18 million from @ausgov. More: www.petermac.org/about-us/new... #CARTCellTherapy #Immunotherapy

I’m excited to share our latest study, published today in @natimmunol.nature.com. It is long known that pregnancy reduces the risk of developing breast cancer, yet the biological mechanisms underlying this protection have remained largely unknown. Read the paper here: www.nature.com/articles/s41...

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer - Nature Immunology

Here the authors identify an abundance of a tissue-resident memory-like T cell population in the breasts of women who have given birth. These cells can contribute to tumor control and may thereby prov...

nature.com

Thrilled to share our newest study led by @categraca.bsky.social and @yannick-alexandre.bsky.social published in @cp-immunity.bsky.social Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳 url.au.m.mimecastprotect.com/s/NE67C6X1Py...

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection

B cells are highly abundant lymphocytes and central players in humoral immunity. Although T cells are well known to support humoral responses, how B c…

url.au.m.mimecastprotect.com

Doherty Institute@thedohertyinst.bsky.social · last mo.

New research reveals B cells do much more than produce antibodies - they also help activate and sustain T cells to fight chronic infections, like cancer or auto immune diseases. https://bit.ly/4wdXKrw

🚨 We’re hiring! We’re looking for a Research Assistant / Junior Postdoc to join the Christie Lab at @petermaccc.bsky.social Ideally the candidate will have experience in analysis of single cell/nuclei RNA sequencing, and be capable of developing bioinformatics workflows and statistical analysis.

Registration & abstracts closing soon for the 1st International Conference on T cells in Health & Disease in Crete, a new conference series in a great location. Plenty of trainee travel awards available but attendance spots are limited so register now: aegeanconferences.org/conferences/...

Do you like beach, summer, Greek food AND T cells??? Then please join us for the 1st Aegean conference on T cells in health and disease aegeanconferences.org/conferences/... Registration closes soon (June 15th)!!!

Great News&Views piece covering the three papers on BACH2 dosing recently published in @natimmunol.nature.com Love the title: BACH2 the future! www.nature.com/articles/s41...

NOW ON YOUTUBE youtu.be/5OHRntr_McU 'Understanding CD8+ T cell Tolerance' Ian Parish, PhD Assoc. Professor & Group Leader, Peter MacCallum Cancer Centre lnkd.in/gkXdZbRy @IanParish_AU 🎙️@dmcmanus123 Thursday, Feb 19th, 2026 5pm ET | 4pm CT | 2pm PT Zoom👇️ lnkd.in/gQime6rC

TCF1 is a master regulator of T cell stemness – but can it make exhausted cells go backwards? We setup a CRISPR KI system to ask this question, and the answer was unexpected. www.nature.com/articles/s41...

High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion @natcomms.nature.com @ianparish.bsky.social @petermaccc.bsky.social @paulbeavis4.bsky.social www.nature.com/articles/s41...

OBS Immunology | Young Investigator Seminar 'Understanding CD8+ T cell Tolerance' Ian Parish, PhD Assoc. Professor & Group Leader, Peter MacCallum Cancer Centre tinyurl.com/Parish-Lab @ianparish.bsky.social 🎙️@danmcmanus123.bsky.social Thursday, Feb 19th, 2026 5pm ET | 4pm CT | 2pm PT Zoom👇️

New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...

Atlas-guided discovery of transcription factors for T cell programming - Nature

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunother...

nature.com

A great piece in ACIR discussing the there papers on #BACH2 dosing for T cell therapy of cancer recently out in @NatImmunol bit.ly/3atHQyV

We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs

Great to see this out, it was fun to work with Roychoudhuri lab on this really nice story. A good illustration that too much "stemness" in T cells can be a bad thing.

Roychoudhuri Lab@roychoudhurilab.bsky.social · 7mo ago

Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...

Peter Mac has been awarded $7.5M+ in @nhmrc.bsky.social Ideas Grant funding for five innovative projects tackling cancer metastasis, treatment resistance and immunotherapy. An outstanding result in a highly competitive scheme! Read more: www.petermac.org/about-us/new...

A $5 million @nhmrc grant will help Peter Mac researchers tackle one of cancer’s toughest challenges: advanced, metastatic disease. The project, led by @belindaparker.bsky.social, will focus on understanding how metastatic cancers evade the immune system. More: www.petermac.org/about-us/new...

👇See our newest study: What was supposed to be a control experiment uncovered a new function of mTOR: 3’mediated translation control in primary human T cells, mediated through DDX21. AU-rich elements are required for this effect. Happy reading! authors.elsevier.com/a/1mDFf3vVUP...

1/ We are making progress towards finding a cure for HIV. In a trial @UCSF led by Steve Deeks and @michaelpelusomd.bsky.social, 7/10 participants who received a combination of immunotherapies achieved partial control of HIV after stopping antiretroviral therapy (ART).🧵 www.nature.com/articles/s41...

We're hiring! We are looking for a Research Assistant with protein biochemistry skills to develop novel protein-based immunotherapeutics targeting Treg cells in cancer. You'll join @roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

cell.com

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

nature.com

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential

Persistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...

biorxiv.org

It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social‬ to preview a great upcoming article in @cp-immunity.bsky.social‬ by @kamphorstlab.bsky.social‬ showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells. www.cell.com/immunity/abs...

The high (I)COSt of costimulation for exhausted T cells

ICOS agonists are being investigated for cancer immunotherapy based on the idea that they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al. unexpectedly find the opposite—th...

cell.com

Online now: The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

Understanding regulation of progenitor exhausted CD8+ T (Tpex) cell differentiation is important for immunotherapies. Humblin et al. report that sustained ICOS costimulation is detrimental to PD-1+CD8+ T cell responses. Limiting ICOS signaling enhances Tpex cell stemness and differentiation into effector-like cells with improved survival and functionality. ICOSL blockade reinvigorates PD-1+CD8+ T cells and promotes viral or tumor control, potentiating PD-1 targeted immunotherapy.

dlvr.it

NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models @nature.com @paulbeavis4.bsky.social www.nature.com/articles/s41...

🎓 PhD positions available @MonashUni Join our lab to explore how neurons and immune cells shape gut immunity! 🧬 Single-cell RNAseq 🔬 3D imaging 🧠 Neuro-immune interactions 👥 Great mentoring & collaborations Apply now 👉 tinyurl.com/Seilletlab

We're looking for an experienced lab manager to join our wonderful team investigating fundamental T cell biology 🤓 careers.pageuppeople.com/513/cw/en/jo...

Join us as a group leader!!! Only a week left to apply to become part of our talented, fun and enthusiastic cancer research faculty in Melbourne. 👇

Ben Hogan@benjhogan.bsky.social · last yr.

A group leader position is open at Peter Mac in Melbourne, Australia! Join us! Applications until May 5. 👇👇 www.nature.com/naturecareer...