Reprocessed an old Glacios dataset and pushed this Fab fragment to 3.8 Å resolution! Not a record-breaker by today’s standards, but still pretty satisfying for a C1 particle with only ~48 kDa of ordered mass. #cryoEM
Ieva Drulyte
@ievadr.bsky.social
Data & AI for Life Sciences @ Databricks | PhD in Structural Biology | Views my own | She/her
Just back from #NIDO2026 in Hong Kong! 🇭🇰 It was a pleasure to present our latest work, catch up with colleagues, and see three Utrecht Virology Lab PhD candidates present their work. Thanks to the organisers for a fantastic meeting and EMBO YIP for the financial support. See you in Banff in 2029!
Honoured to receive the first Sir Dave Stuart Early Career Award today. Dave was my PhD external examiner, making this award, recognising his contributions to structural biology, especially meaningful to me. Thank you to Instruct-ERIC and Thermo Fisher Scientific for championing ECRs.
Thank you again for the invitation @instruct-eric.bsky.social! I really enjoyed the workshop and the discussions throughout the day. Excited to see these conversations and initiatives continuing to grow in structural biology!
Instruct-ERIC@instruct-eric.bsky.social · 2mo agoAlso speaking at the Women in Science workshop, we have @ievadr.bsky.social of WeINSPIREBio. Instruct-ERIC is happy to support the mission of WeINSPIREBio "empower, connect, and elevate women scientists in the fields of structural biology and structure-based design"!
Excited to share our new preprint! Using deep mutational scanning and multivalent engineering, we developed our SARS-CoV-2 spike-targeting macrocyclic peptide into a potent inhibitor that blocks infection in HAE cultures and protects hamsters after intranasal dosing. chemrxiv.org/doi/full/10....
Development of a Multivalent Macrocyclic Peptide that Shows In Vivo Protection Against SARS-CoV-2 Infection Following Intranasal Administration | ChemRxiv
The risk of zoonotic spillover of coronaviruses poses a constant threat to humanity, as recently exemplified by SARS‑CoV-2. During the pandemic, the rapid emergence of immune escape mutations led to a loss of efficacy of both therapeutic and humoral anti‑...
chemrxiv.org
Applications and prospects of cryo-electron tomography in drug discovery and understanding disease Review article by @camilaclemente.bsky.social in our lab www.sciencedirect.com/science/arti...
Applications and prospects of cryo-electron tomography in drug discovery and understanding disease
Cryo-electron tomography (cryo-ET) is emerging as a transformative tool for structural biology. Unlike methods based on purified molecules, cryo-ET en…
sciencedirect.com
Honoured to receive the 2026 ACS Infectious Diseases Early Career Award alongside Laura Dassama and Patrick Dolan! Grateful for this recognition, and especially grateful to my wonderful colleagues, collaborators, and lab members who made the work possible. axial.acs.org/biological-c...
Biological and Medicinal Chemistry 2026 Lectureship and Award Winners | ACS Publications Chemistry Blog
Learn about the 2026 winners of ACS Publications' Biological and Medicinal Chemistry lectureships and awards.
axial.acs.org
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
2D classes of the 58 kDa sample collected on the 100 keV Tundra TEM with a Falcon C detector at @nusbf.bsky.social @newcastleuni.bsky.social. Still much work to do to optimise the sample & data collection but its cool to see what a 100 keV TEM is capable of. #cryoEM @recon4imd.bsky.social
We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...
For a plain-language overview of our work, see this lay summary courtesy of Kudos: www.growkudos.com/publications...
Shapeshifting spike proteins help coronaviruses infect whales and dolphins
Coronaviruses use spike proteins to enter cells. This study shows these spikes can change shape, helping the viruses adapt to new hosts, including whales and dolphins. Understanding this flexibility may help predict and prevent future cross-species infections.
growkudos.com
Our paper describing the #cryoEM structures of unusual spike proteins from marine mammal–infecting gammacoronaviruses is now published in PLOS Pathogens! 🐬 journals.plos.org/plospathogen...
Cetacean coronavirus spikes highlight S glycoprotein structural plasticity
Author summary Coronaviruses are well known for their ability to jump between species, a process driven mainly by the spike protein on their surface. In this study, we examined spike proteins from coronaviruses found in marine mammals (whales and dolphins) to better understand how these viruses evolve and interact with their hosts. Using structural biology and mass spectrometry, we discovered several unusual features of the cetacean spike proteins. These spikes contain an extra domain within their receptor-binding region that resembles cupin proteins, assemble into trimers in a novel way that hides the receptor-binding domains, and show clusters of sugars (O-linked glycans) near the sites thought to interact with host receptors. These distinctive features suggest that cetacean coronaviruses may use a different entry mechanism, in which the extra domain acts as a switch to reveal the hidden receptor-binding regions. Such a mechanism could affect which species these viruses can infect, how easily they cross species barriers, and how they evade the immune system. Our findings emphasize the structural diversity and modularity of coronavirus spike proteins, highlight the unique adaptations of coronaviruses in marine mammals, and provide insight into their potential to give rise to new diseases in other species.
journals.plos.org
Daniel Hurdiss@danielhurdiss.bsky.social · last yr.Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses. www.biorxiv.org/content/10.1... This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.
Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation. www.biorxiv.org/content/10.6...
@embo.org Practical Course: Advances in cryo-electron microscopy and 3D image processing 📅 17-25 August 2026 📍 @embl.org Hamburg 📝 Registration Open| Deadline: 11 May 2026 🔗 instruct-eric.org/events/embo-... #cryoEM #Training
EMBO Practical Course: Advances in cryo-electron microscopy and 3D image processing
<p>We are delighted to announce the 2026 EMBO Practice Course on “<a href="https://www.embl.org/about/info/course-and-conference-office/events/cry26-01/#vf-tabs__section-dtc24-01" target="_blank"…
instruct-eric.org
New Online! Overcoming the challenge of preferred particle orientation in cryo-EM
Overcoming the challenge of preferred particle orientation in cryo-EM
Nature Reviews Molecular Cell Biology, Published online: 26 March 2026; doi:10.1038/s41580-026-00962-4Yang and Liu discuss strategies that help address particle orientation bias in cryogenic electron microscopy (cryo-EM), and offer practical advice to tackle it.
dlvr.it
The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!
Cryo-electron microscopy scientist
Join our team to contribute to the operation and innovation of state-of-the-art cryo-electron microscopes and empower groundbreaking research.
uu.nl
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social www.nature.com/articles/s41...
Cryo-EM success starts before the microscope. Join us @royalmicrosoc.bsky.social for a free Cryo-EM SPA mini-course (1 of 3) on sample prep. Learn purification, grid prep & screening tips + live Q&A. 🗓️ Apr 14 Register once to attend all 3 - Sample Prep, Collection, Processing 👉 ter.li/pksdqb
Excited to welcome @tejashyamk.bsky.social to the ERC starting grant team, as he starts his PhD! Teja joins us from @sc-lab.bsky.social, where he built a solid foundation in biochemistry & #cryoEM 🔬 He’ll be uncovering new insights into norovirus replication and assembly. Exciting science ahead!
February Map of the Month: Aca2–RNA We reprocessed EMPIAR-11918 and achieved 2.76 Å in 50.5 compute hours. Sub-3 Å at ~40 kDa is a strong example of what modern cryo-EM workflows (and RELION with Blush) can deliver for small targets. 📧 hi@cryocloud.io #CryoEM #CryoCloud
Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation pubmed.ncbi.nlm.nih.gov/41702403/ #cryoEM
Not every day your work helps protect baby elephants 🐘💙 Super proud to have contributed to the cryo-EM part of this project - it also happens to be my 20th publication, which makes it feel extra special ☺️
Daniel Hurdiss@danielhurdiss.bsky.social · 8mo agoHow can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬 Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉 www.biorxiv.org/content/10.6...
Honoured to be selected as one of this year’s EMBO Young Investigators! Grateful to my team and colleagues for all their support, and excited about the opportunities this will create for my group and for our work in structural virology. www.embo.org/press-releas...
🌟 WeINSPIREBio is hosting its first event! On Dec 4, we’re running a webinar: Structures of Success: Career Journeys of Women in Structural Biology If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼 lnkd.in/ewjD5WPt #cryoEM
Heading to #PSDI2025 in Basel! Excited for good science, great discussions and familiar faces. Come say hi or book a chat with us!
CryoCloud@cryocloudio.bsky.social · 9mo agoWe’re heading to #PSDI2025! Meet the CryoCloud team and don’t miss our talks: ⚡ Sun 9 Nov: Towards Automating Cryo-EM Data Analysis 🚀 Tue 11 Nov: Accelerating Data Analysis with CryoCloud Drop by our booth or book a chat 👇 connect.cryocloud.io/meetings/cry... #CryoEM #XrayCrystallography
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
uu.nl
Yikes! In this paper the AlphaFold model of human plasminogen (PDB-8uq6) has been refined into noise (EMD-42462) using Phenix & ISOLDE. For some reason the authors even interpret side-chain interactions: #cryoEM
cryoEM papers@cryoempapers.bsky.social · 10mo agoInteractions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy pubmed.ncbi.nlm.nih.gov/41069681/ #cryoEM
✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1...
