WATCH THIS ⬇️⬇️⬇️ Extremely interesting and insightful: Zack Polanski's refreshingly down to earth conversation with Thomas Piketty about inequality, its underlying causes, its consequences and possible ways of addressing it. Grab a cuppa, it's a long watch.

Zack Polanski@zackpolanski.bsky.social · 5d ago

I went to Paris to speak to Thomas Piketty - one of the world’s leading thinkers on inequality. We talk about why wealth keeps concentrating at the top, the case for public investment, and what it would take to build a fairer economy. A fascinating conversation. youtu.be/d_83pFubGvQ?...

Tau-induced mitochondrial reverse electron transport drives neurodegeneration www.cell.com/neuron/abstr...

Tau-induced mitochondrial reverse electron transport drives neurodegeneration

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

cell.com

If you would like to teach theoretical modeling skills to your psychology or cognitive science students, or would like to learn these skills yourself, check out our open online textbook: computationalcognitivescience.github.io/lovelace/

Hunter J. Weaver and colleagues reveal that pharmacological corticosterone suppresses pro-inflammatory cytokines in brain and peripheral tissues, independent of sleep fragmentation, revealing tissue-dependent glucocorticoid immune regulation. doi.org/10.1242/bio....

Biofilm formation in #Bacillus subtilis is thought to precede sporulation, but T. Updegrove says that a subpopulation of sporulating cells triggers other cells to become biofilm formers via an intracellular metabolite (glycerol) repurposed as a signaling molecule (!) www.science.org/doi/10.1126/...

A metabolite morphogen coordinates multicellular development in Bacillus subtilis

Cell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.

science.org

Drinking-water disinfection byproducts were linked to higher uterine cancer risk among California women.

I think being anti AI is entering a more mainstream phase! While incredibly good at the same time we're finally meeting a low bar. This means: 1) more critical thinking is needed now as non-experts are making anti AI arguments so we could promote worse arguments overall — remember: 1/

Olivia Guest · Ολίβια Γκεστ@olivia.science · 8mo ago

Respecting Expertise is the epistemic compact between professionals and society. See section 5 here: doi.org/10.5281/zeno... 6/

Less protein, more lifespan! A comprehensive review of the merits of protein restriction for healthy aging A flip from the proteinmaxxing craze cell.com/cell-press-b...

www.science.org/doi/10.1126/...

Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging

Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.

science.org

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

☕Nguyen et al. show that accumulation of dimethylarginine in lysosomes in disease models is associated with lipotoxicity and lipid droplet abundance. 👉https://rdcu.be/fvKac www.nature.com/articles/s41...

Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome - Nature Cell Biology

Nguyen et al. show that accumulation of dimethylarginine in lysosomes in disease models is associated with lipotoxicity and lipid droplet abundance.

nature.com

🥂In a recent study in our journal, the authors combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN) subtypes and a VEN signal-processing strategy. www.nature.com/articles/s41...

An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons - Nature Cell Biology

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

nature.com

A new, rather unexpected glycolipid class. Very well done study. Given how they look structurally, I think it makes a lot of sense to test these lipids against a panel of GPCRs. Lipid biology keeps surprising me. I like that. www.biorxiv.org/content/10.6...

We've known micro- and nanoplastics get into the body. Showing they actually do harm has been much harder. This new study in the European Heart Journal is one of the more provocative attempts. buff.ly/1sEeCVq

This is absolutely brilliant! From an educational point of view, from a coding point of view, from a design point of view, whatever point of view you want to take, it's a fantastic lesson in probability and statistics.

Ming Tommy Tang@tommytang.bsky.social · 2mo ago

solid foundation in statistics is even more important in the age of AI. This interactive app explaining statistic concepts is great seeing-theory.brown.edu/index.html

In our Viewpoint (onlinelibrary.wiley.com/doi/abs/10.1...) we synthesize the gametic definition (outlined by Janicke et al below) and other definitions of sex (e.g., multivariate definition). We contend that is NO consensus on “biological sex” (maybe a consensus isn’t actually necessary…)

There is No Consensus on Biological Sex

At this critical moment when misinformation about sex is being applied to policy globally, scientific clarification on the definition of biological sex is valuable. Here, we evaluate the primary appr...

onlinelibrary.wiley.com

Tim Janicke@timjanicke.bsky.social · last mo.

In a new #Viewpoint we argue that the binary definition of #BiologicalSex based on gamete size is a scientifically robust framework that is entirely compatible with the diversity of sexual phenotypes and human gender identities. onlinelibrary.wiley.com/doi/10.1111/...

The Origin of Life in the Light of Evolution Another food for thought paper with @lauraeme.bsky.social and a lot of fantastic scientists. arxiv.org/abs/2605.05464

The Origin of Life in the Light of Evolution

The origin of life is often framed primarily as a chemical problem, yet life's defining feature is evolution. Advances in geochemistry, prebiotic chemistry, and molecular biology have produced diverse...

arxiv.org

Every time I read a paper that challenges our view of the central dogma, I'm amazed by the complexity of biology and almost overwhelmed by the challenge of unraveling this compelixity. Tsour et al., Nature (2026) - www.nature.com/articles/s41... (1/3)

Alternate RNA decoding results in stable and abundant proteins in mammals - Nature

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and dise...

nature.com

Préparez-vous pour une nouvelle descente aux enfers. Avec cette deuxième vague de chaleur (7jours de durée), des records devraient à nouveau être battus au Portugal, en Espagne, en France, en Angleterre, Allemagne... Prenez soin de vous, prenez soin des plus fragiles.

As you might imagine, as someone who studies science and works on metrics, I have some thoughts on qed myself. I fully agree that the messaging can be described as tone-deaf and problematic. I don’t think it had to be. ripplingideas.org/2026/06/26/t...

The 1% club and the rocky road ahead for bioRxiv

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…

ripplingideas.org

Read the Review article "Glycosphingolipids in cell identity: Biosynthesis, functions, and emerging tools" from Dr. Pavel Barahtjan, Nika Goršek, Jean Maillat, and Giovanni D'Angelo: authors.elsevier.com/sd/article/S...

Glycosphingolipids in cell identity: Biosynthesis, functions, and emerging tools

Cell fate is shaped by external cues and intrinsic cellular states. While supracellular signals, such as growth factors, provide instructive guidance,…

authors.elsevier.com

Il est essentiel de documenter ce qui pourrait constituer un nouveau cas majeur en France. Si vous le pouvez, photographiez chaque jour votre jardin, un arbre, une haie ou un paysage végétalisé depuis exactement le même point de vue, à partir d'aujourd'hui et pendant les dix prochains jours. 6/7

Since I did do my PhD in cyanobacteria growth and treatment optimization modeling AND work in the water treatment industry, I’m gonna share my theory as to what’s happening here and how to fix it. People are focusing on the painted bottom of the pool increasing residual heat, and while that 1/19

derek guy@dieworkwear.bsky.social · 2mo ago

RIP Mark Rothko. You would have loved how the hydrogen peroxide bleach is only turning the Reflecting Pool blue around the perimeter

Interesting resource for those starting with #Drosophila research (set of videos by Bruno Lemaitre) youtu.be/aUewlFU-6rw?...

Drosophila Genetics 1 Basic Knowledge edX compressed

YouTube video by Bruno Lemaitre

youtu.be

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

Out Now! Purine bias in bacterial genes is driven by runaway transcription #MicroSky

Purine bias in bacterial genes is driven by runaway transcription

Nature Microbiology, Published online: 15 June 2026; doi:10.1038/s41564-026-02389-1Purine bias is critical for gene expression in bacteria, preventing premature transcription in species that exhibit runaway transcription.

go.nature.com

Fascinating finding with direct clinical implications: Placental nicotinamide adenine dinucleotide modulates the timing of labor | Science www.science.org/doi/full/10....

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

(J Sep Sci) Microwave‐Assisted Meta‐Chloroperoxybenzoic Acid Epoxidation for Qualitative and Quantitative Analysis of Unsaturated Lipid Double‐Bond Positional Isomers by Liquid Chromatography–Tandem Mass Spectrometry: ABSTRACT Unsaturated lipid double-bond (C═C) positional… #JSepSci #MassSpecRSS

Microwave‐Assisted Meta‐Chloroperoxybenzoic Acid Epoxidation for Qualitative and Quantitative Analysis of Unsaturated Lipid Double‐Bond Positional Isomers by Liquid Chromatography–Tandem Mass Spectrometry

ABSTRACT Unsaturated lipid double-bond (C═C) positional isomers are closely related to lipid structure and biological function, but their reliable qualitative and quantitative analysis remains challenging by conventional liquid chromatography–mass spectrometry (LC-MS) methods. In this study, we developed a microwave-assisted meta-chloroperoxybenzoic acid (m-CPBA) epoxidation method coupled with LC–tandem MS for the identification and quantification of unsaturated lipid C═C positional isomers. The reaction conditions were optimized to facilitate the formation of fully epoxidized products, simplify the chromatographic peak profiles, and enhance their suitability for targeted quantitative analysis. The developed method showed good analytical performance, including satisfactory linearity (r 2 > 0.99), precision (relative standard deviation

dlvr.it

Do you know an outstanding aquarist? We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3 [Pls repost!]