Isabel Monte

@isabelmonte.bsky.social

Junior Professor at @zmbp-tuebingen.bsky.social Evolution of Plant Signaling Lab. EXC GreenRobust and TERRA. Interested in plant molecular evolution, RKs, EvoMPMI, Marchantia 💚 and Trichoderma 🍄‍🟫

Looking for BGCs in large metagenomic datasets? Our new biorxiv preprint introduces metaSMASH, a scalable fork of antiSMASH designed specifically for metagenome-scale BGC detection and analysis : www.biorxiv.org/cgi/content/... Thanks @canerbagci.bsky.social and @kblin.bsky.social ❤️

metaSMASH: Scalable Biosynthetic Gene Cluster Detection for Large Metagenomic Assemblies

antiSMASH is widely used for biosynthetic gene cluster (BGC) detection and annotation, but its standard workflow is poorly suited to large metagenomic assemblies, where massive contig counts create severe runtime bottlenecks and complicate downstream result exploration. We present metaSMASH, a re-engineered fork of antiSMASH for metagenome-scale BGC analysis. metaSMASH preserves the original antiSMASH detection and annotation logic while introducing streaming, memory-bounded execution, record-level parallelisation, optional output filtering, and an interactive dashboard for large result sets. Across 25 benchmark metagenome datasets, metaSMASH reproduced identical BGC detection results while dramatically reducing computational cost. Relative to the default antiSMASH configuration, metaSMASH was a geometric-mean 38x faster. It also outperformed an ad hoc chunked antiSMASH workflow: in the default configuration it achieved a geometric-mean 2.9x speed-up and 1.7x lower peak memory, and with extended-analysis modules enabled it was 2.7x faster and used 3.1x less memory while completing all datasets, whereas the ad hoc workflow ran out of memory on the two largest assemblies. By substantially reducing the computational burden of large-scale metagenome analysis without sacrificing result equivalence, metaSMASH makes routine mining of assembled metagenomes more practical and provides a scalable foundation for natural product discovery from complex microbial communities. ### Competing Interest Statement The authors have declared no competing interest. German Center for Infection Research, TTU Novel Antibiotics 09.716 Volkswagen Foundation, 0072511-00

biorxiv.org

Together with Mathieu Hanemian, we're searching for an undergrand student (Master or Erasmus internship, final-year engineering student) to explore the effect of intercropping on the soil microbiota. If this sounds interesting to you, please reach our with your CV and a motivation letter!

Internship objectives 
The main objective of the internship will be to determine how intercropping modifies the composition and 
functions of the rhizosphere microbiome associated with each cultivated species, in comparison with sole 
crops. The intern will also seek to identify common microbial signatures across different intercropping 
systems in order to highlight potential general mechanisms associated with plant diversification. Particular 
attention will be paid to the functions potentially associated with the observed changes, based on the 
identification of microbial taxa and targeted qPCR analyses. 
The intern will participate in the entire analytical workflow, from molecular biology procedures (DNA 
extraction, PCR, preparation of sequencing libraries) to bioinformatic data processing, statistical analyses 
using R, and biological interpretation of the results. The results will contribute to identifying the microbial 
mechanisms that may explain the agronomic benefits of intercropping and may help guide the development 
of new agroecological practices.

Tomato MIK2A and Arabidopsis MIK2 appear to sense the same elicitor activity from Fusarium oxysporum. Both share some ectodomain surface amino acids for elicitor sensitivity. Tomato MIK2A, however, does not sense SCOOPs or SCOOP like peptides. Evolution of the MIK2 receptor clade is discussed.

New Phytologist@newphyt.bsky.social · 3w ago

A tomato MIK2-clade receptor is involved in the perception of a Fusarium-derived elicitor Maroschek et al. nph.onlinelibrary.wiley.com/doi/10.1111/...

Elicitor responsiveness and phylogeny of MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2-clade genes in plants of different orders.

Thanks to all the speakers and participants in the "Plant Robustness from molecules to ecosystems" session at the #SEB2026 conference! Exciting science and great discussions sponsored by @theplantjournal.bsky.social and our Excellence Cluster @greenrobust.de 🌱 with @kaspervangelderen.bsky.social

Kasper introducing our Excellence Cluster GreenRobust as sponsor of the SEB 2026 session on Plant Robustness from molecules to ecosystems in FlorenceFishbowl discussion on plant robustness including ECRs and invited speakers and moderated by Kasper in the P12 session on Plant Robustness from the SEB 2026 Annual Conference in Florence (Italy)
Kasper van Gelderen@kaspervangelderen.bsky.social · 4w ago

Very happy with our @greenrobust.de @isabelmonte.bsky.social Plant Robustness session at the @sebiology.bsky.social conference. Excellent talks by @hildenelissen.bsky.social, Marcel Quint, @rsasidharan.bsky.social and Amy Austin. Great fishbowl discussion on plant robustness! Thanks PlantJ

Had a lovely time participating in this @sebiology.bsky.social session on plant robustness excellently organized by @kaspervangelderen.bsky.social @isabelmonte.bsky.social Thanks for inviting me! @greenrobust.de @uuplants.bsky.social

Kasper van Gelderen@kaspervangelderen.bsky.social · 4w ago

Very happy with our @greenrobust.de @isabelmonte.bsky.social Plant Robustness session at the @sebiology.bsky.social conference. Excellent talks by @hildenelissen.bsky.social, Marcel Quint, @rsasidharan.bsky.social and Amy Austin. Great fishbowl discussion on plant robustness! Thanks PlantJ