A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines www.nature.com/articles/s41... @lozanzi.bsky.social @harvardmed.bsky.social @natimmunol.nature.com

Huge congratulations to @elvirab.bsky.social on an outstanding PhD viva! A well-deserved achievement reflecting years of hard work, perseverance, scientific curiosity, and intellectual growth. It has been a privilege to mentor this journey. Excited to see what comes next. 🎓👏

Belated post of my macaron centrepiece from last week’s @ciiid-hudson.bsky.social Christmas party – “the cells of CiiiD”. A lot of work to produce this undetermined number of macarons (I lost count) 🙃 Big thanks to @biorender.bsky.social who I used to make the templates! @hudsonresearch.bsky.social

Never expected to be mentioned in the Nature Briefing www.nature.com/immersive/d4...

The gift that shaped my career in science

Nature asked about your most memorable scientific gifts. You delivered.

nature.com

Congrats @lauracanaday.bsky.social @andypedsid.bsky.social @hafeldman17.bsky.social & team on our newest publication @jimmunol.bsky.social Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection academic.oup.com/jimmunol/adv...

Waggoner Lab@labwaggoner.bsky.social · last yr.

Excited to share preprint (currently in revision) from the PhD dissertation of my former student @lauracanaday.bsky.social. Thanks to @andypedsid.bsky.social @hafeldman17.bsky.social and the rest of the team for their hard work. biorxiv.org/content/10.1...

We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2

Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens

Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8 licenses noncanonical inflammasome activation and pyroptosis during intracellular bacterial infections in human...

cell.com

One month left until early registration closes! Apply now if you would like to be considered for a talk. It will be an amazing conference bringing together leading scientists in the field of protein design. [Protein Emoji]

Ajasja💻🧬🔬@ajasjaljubetic.bsky.social · last yr.

Early bird registration for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓 is open! 🎉🎉🎉 Come join us for three days of protein design fun! (October 20-22, 2025) Direct registration link: pretix.eu/SBD/RCon2025/ Website: europeanrosettacon.org We are looking forward to seeing you! Please share this far and wide:)

NLRP3 inflammasomes can assemble on most organelles. A beautiful study by Hafner et al demonstrate the flexibility of organelles that can support inflammasome activation. Kudos to the authors on an intriguing study. www.nature.com/articles/s41... @ivahb.bsky.social @elvirab.bsky.social

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications

NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...

nature.com

Subcellular location of NLRP3 is not essential, but clustering on different scaffolds is. This explains how NLRP3 can react to so many diverse stress signals. 9/9

Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in @natcomms.nature.com: nature.com/articles/s41... See 🧵👇 1/9

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications

NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...

nature.com

Check out Elvira's explanation of the freshly published study below...

Elvira Boršić Mlinarič@elvirab.bsky.social · last yr.

Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in @natcomms.nature.com: nature.com/articles/s41... See 🧵👇 1/9

Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social www.nature.com/articles/s41...

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications

NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...

nature.com

Two-dozen billion-dollar U.S. startups were founded by foreign students who studied at Harvard --Axios. Making America Poor Again Making America Dumb Again

Just like we need women in STEM and "Girls Who Code", we need “Men Who Nurse” and “Guys Who Teach,” pipeline programs that can offer boys pathways forward in female-typed fields. @reshmasaujani.bsky.social time.com/7286184/worr...

I Founded Girls Who Code. Now I’m Worried About Boys

Boys and men are less likely to turn to their communities for social connection and support.

time.com

Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids pubmed.ncbi.nlm.nih.gov/40140423/ #cryoEM

Exciting times ahead! Kicking off our new EIC Pathfinder project SCALPEL: www.linkedin.com/posts/scalpe...

#scalpel #groundbreaking #cancertreatment #photomedicine #immunotherapy… | SCALPEL-Project

✨ Lighting Up a New Era in Cancer Treatment ✨   We are excited to introduce #SCALPEL – a #groundbreaking, Europe-wide initiative that is set to redefine…

linkedin.com

Congratulations to the Unesco L'Oreal For Women in Science (Slovenia) Awardees! siol.net/novice/digis...

S čim so prepričale te tri mlade slovenske znanstvenice?

Za odličnost njihovega raziskovanja bodo letos nagrajene molekularna biologinja Tajda Klobučar, raziskovalka na področju biomedicine Sara Orehek in kognitivna nevroznanstvenica Manca Peskar.

siol.net

Damon Runyon Cancer Research Foundation awards $4.4M to top young scientists www.damonrunyon.org/news/entries...

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

This administration is taking a blowtorch to the entire education path from early childhood programs to undergrad universities to higher ed as we look on. Any US company/institution that relies on a well-educated workforce is going to lose its competitive edge. This is a ⏰⏰⏰⏰🔥🔥national crisis

Excited to join bsky.social! 🌟 Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia. www.embopress.org/doi/full/10....

Researchers at the National Institute of Chemistry have developed a novel therapeutic strategy called cytokine-armed pyroptosis. The study, published in @naturecomms.bsky.social , will be presented by first author Sara Orehek on January 23, 2025, at the Forum 40 lecture series. bit.ly/4ho2e7m

Check this video where he Head of the #CTGCT prof. dr. Mojca Benčina appeared in the news of the Slovenian national TV as one of the breakthrough discoveries by Slovenian scientists in 2024. lnkd.in/dtx6VyNT #research #ultrasound #innovation #cellandgentherapy

Researchers (from @ivahb.bsky.social's group and #CTGCT) developed a way to enhance the immune system's ability to combat cancer combining pyroptosis, with specific cytokines that boost immune activity. www.nature.com/articles/s41... #CancerResearch #Immunotherapy #Innovation #Science

Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications

‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...

nature.com

As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek. www.nature.com/articles/s41...

Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications

‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...

nature.com

Such a great opportunity! I took this course in grad school in 2001. It was transformative for my thinking and led to some lifelong friendships. Highly recommend!

Typas Lab@typaslab.bsky.social · 2y ago

You want to learn about microbiology from a fantastic lineup of speakers on a beautiful Greek island? PhD students apply now for the @EMBO | @FEBSnews Lecture Course The New Microbiology! Registration: 1 Apr 2025 Course: 03 – 11 Sep 2025 | Spetses, Greece meetings.embo.org/event/25-new...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

rdcu.be

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology

Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

nature.com

PhD project with Ioannis Kourtzelis, our lab and Mesenbio in lovely York! Macrophage, EV and innate immune responses, what's not to love! www.findaphd.com/phds/project...

CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York on FindAPhD.com

PhD Project - CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York, listed on FindAPhD.com

findaphd.com