Jack Holcombe
@jackholcombe.bsky.social
Science, data and climbing http://jackholcombe.com/
Everywhere I look today I keep seeing: 1) deadly wildfires ripping through our communities 2) people desperately trying to get by as energy costs soar 3) record oil & gas profits When will we see that these three things are connected? www.wsj.com/business/ene...
Big Oil Is Reaping Rewards From the Chaos in Energy Markets
ExxonMobil’s earnings doubled and Chevron posted its highest quarterly earnings on record as energy prices soared during the prolonged closure of the Strait of Hormuz.
wsj.com
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
cell.com
Big new story from @annaisaac.bsky.social. Cottrell transferred $2m to his mother before she made Reform & Tice donations. The even bigger question now is where did Cottrell’s money come from? And this is where I think a very big problem lies.. www.theguardian.com/politics/202...
Revealed: George Cottrell transferred $2m to his mother days before her donations to Reform UK
Exclusive: Sources say Fiona Cottrell told bankers the transfers, received 24-72 hours before her donations to Reform, came from her son
theguardian.com
Excited to share a new preprint from the lab, by @andrewmatheson.bsky.social and team, where we dive into the superpower of newts: plasticity! www.biorxiv.org/content/10.6... Like many good projects, this started with a serendipitous observation... 🧵1/5
Please share, I am hiring an evo devo postdoctoral research fellow! 📍: The Sleight Lab, University of Aberdeen, Scotland (5th oldest University in UK & English-speaking world) 📅: start after 1st December 2026 🐌: Evolution and Development (molluscs) ⌛: 3 year contract sleightlab.com/vacancies/
*Company that directly financially benefits from war warns us that we are not giving them enough money
Unofficial BBCNews (UK) Bot@bbcnews-uk-rss.bsky.social · 2w agoUK complacent about war threat, warns BAE Systems' boss
Ridiculous sweeping statement (written by a psychologist)
Steve Elardo@steve-elardo.com · 2w ago“A marathon can be run in 30 minutes”
Love to see it, Argentina were a complete disgrace 🇪🇸🎉
I trust the people of Clacton to judge me on my record. Apart from the record that shows I have visited American more times than Clacton, have never held a constituency surgery and rarely bother to drag my arse into Parliament to do my actual job.
We're excited to present a single-cell atlas of vertebrate cranial motor neuron development, the first story from my postdoctoral work in the Moens lab, up now on bioRxiv!
We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!
Early visual experience elicits cellular and functional plasticity in the retina and alters behavior
The understanding of experience-dependent plasticity in the vertebrate retina is largely incomplete. Reynolds et al. discovered that raising animals in differently patterned visual environments change...
cell.com
The awesome trio of @lmescu.bsky.social @fpichaud.bsky.social and Fernando Casares (and their teams) are on fire Fly eyes represent 'programmable metamaterials'; human engineering principles pre-exist in biology www.nature.com/articles/s41...
A natural programmable metamaterial controls 3D curvature of compound eyes - Nature Communications
This article uncovers a natural, programmable metamaterial in the developing Drosophila eye. The precise 3D curvature of the adult compound eye is programmed during development by a microscopic, 2D tr...
nature.com
Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...
Transforming avian to mammalian modes of digit patterning
How a conserved embryonic organiser-the Sonic hedgehog (Shh)-expressing Zone of Polarising Activity (ZPA)-generates diverse limb architectures in amniotes remains a central problem in evolutionary and...
biorxiv.org
Key details missing - how much did he pay in income tax vs capital gains? Why do they still get a sovereign grant whilst owning billions in property/land?
Unofficial BBCNews (UK) Bot@bbcnews-uk-rss.bsky.social · last mo.King Charles reveals he paid £12.9m in tax for 2024-25
BBC article about Brian Ripley of the #RStats Core team given this week's excellent news concerning 2026 Rousseeuw Price for Statistics recognition for him and the core team. www.bbc.com/news/article...
Prof Brian Ripley on developing R to manage the world's data
Prof Brian Ripley has spent the past three decades working on a computer software that analyses data.
bbc.com
This is what happens when we allow people like Fromage to gain a voice and stir up hatred...
Glasgow Times@glasgowtimes.bsky.social · 2mo agoA racist attack targeted people at random because of their skin colour
Do you know an outstanding aquarist? We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3 [Pls repost!]
You have no idea how proud I am of of this paper from the lab showing that RANK signalling affects the development of Tuft and BEST4 cells in the zebrafish gut, with in vivo evidence indicating that BEST4 cells contribute to defences against enteropathogens
Rank-dependent control of tuft and BEST4 cell development in the intestine - Nature Communications
Here they provide evidence that RANK signaling contributes to specification of intestinal epithelial tuft and BEST4 cells, and that loss of RANK impairs the ability of the host to navigate infections ...
nature.com
Both caffeinated and decaf coffee altered gut bacteria in ways linked to better mood and lower stress. Decaf even improved learning and memory, while caffeine boosted focus and reduced anxiety.
(3/15) Eels are basal teleosts with elongated bodies. Many species have massively expanded vertebral counts (Japanese eel: 120 vertebrae). The Aulehla Lab studies somitogenesis — the embryonic process that gives rise to vertebrae — and we wanted to understand how this unfolds in eels.
Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism
In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
nature.com
Glad the BBC are prioritising the most important global stories on the front page this morning.
Why do people respond differently to GLP-1 weight-loss drugs? Genetics has the answer - provided in this genome wide association study led by @adamauton.bsky.social www.nature.com/articles/s41... 🧪 www.nature.com/articles/d41...
Genetics reveal why people respond differently to GLP-1 weight-loss drugs
Genetic variants in GLP1R and GIPR, which encode targets of GLP-1-based medications, offer insights into why responses to these drugs vary and who might face adverse effects.
nature.com
Well thats awkward www.cell.com/cell-reports...
MitoTracker transfers from astrocytes to neurons independently of mitochondria
The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...
cell.com
Like #hemocytes? I'm advertising a 3 year, BBSRC #postdoc position, in #Edinburgh, using #Drosophila & human cells to understand sex differences in the regulation of #macrophage function, an exciting collaboration with the Bénézech and Wood labs. Please share! 🪰🏴 www.jobs.ac.uk/job/DQU604/p...
Postdoctoral Research Associate at The University of Edinburgh
Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
jobs.ac.uk
