Jakub Zeman
@jakub-zeman.bsky.social
Postdoc with interest in ribosomes, proteins, cardiomyocytes, human embryonic cell fate... ...cats, investing, and sarcasm.
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
our 5th paper of 2026 is out: ONE microscopy www.nature.com/articles/s41... #Protein shapes, #sub-nanometer precision, conventional #fluorescence #microscopes, and now #ONEpy. 3 more papers in revision, more this year. We’re only getting started. #optical #structural #biology is becoming a field
Leo (@kurianlab.bsky.social) and I put together a Technology preview for Molecular Cell on Ribo-Tweezer, a method that enables the removal of a ribosomal protein from a fully assembled ribosome. Check the original study published by @mbarnalab.bsky.social! authors.elsevier.com/c/1nN3p_Oylr...
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Kurianlab@kurianlab.bsky.social · 3mo agoRibo-Tweezer by @mbarnalab.bsky.social, a modular platform to deplete proteins from mature ribosomes . www.cell.com/molecular-ce... @jakub-zeman.bsky.social and I wrote a Preview on why this helps to turn ribosome heterogeneity into an experimentally testable paradigm www.cell.com/molecular-ce...
Real science: 1. Is not correlated with the amount of funding 2. Progresses slowly, usually taking many years 3. Leads to more questions than it answers 4. Advances when we disengage a bit and have improvisational discussions 5. Is too serious a thing to be done in a non-playful way
Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)
We're excited to welcome Leoš to Frankfurt soon! He'll be sharing fascinating insights about biological systems where start codons don't matter much, and stop codons make more sense than expected. Don't miss his talk on June 16 at Campus Niederrad! #translation Info: mbu.cas.cz/en/aktuality...
@sholtodavid.bsky.social Have you seen this WB from ThermoFisher? Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557). It also looks like that the band in lane 3 was rotated and reused in lane 4. Moreover, it seems that same band was used for the 2 different clones.
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.
Try this new online training game from Leandro F. Estrozi designed for newcomers in structural biology, with a focus on cryo-EM and cryo-ET map interpretation: rico.ibs.fr/helixplo...
Are you looking for a new challenge? We are looking for a Deep Learning Engineer. With this role you would set up deep learning infrastructures with the goal to understand genomes 🧬 and ageing 👵 .
Cellular phallus. Unfortunately, it was not discovered in Brno.
Oliver Rocks@oliverrocks.bsky.social · 5mo agoCheck out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
It's our 12-year anniversary. Grateful to work with a great group of young scientists in those years. very proud of what we have done, and very thankful for sticking with our lab values in very tough times indebted to @erc.europa.eu @cpi-exstra.bsky.social @goetheuni.bsky.social current lab
@lufthansagroup.bsky.social cancelled my flight more than 4 weeks ago. Since then, they have not been able to reimburse me despite repeated requests. I need to wait for hours on their chat to get zero answers. Don't be like Lufthansa. I am filing a complaint with the German Luftfahrt-Bundesamt.
We've spent the last year building something at @humantechnopole.bsky.social that we think is genuinely needed: #AI that works across biological scales and data modalities, not just within them. A thread on what we're doing, why, and who we're looking for. A 🧵... 1/9
I appreciate someone took the time to write this. I profoundly disagree with their view, but if I take the spirit of what they're saying as a good faith attempt to raise a mental issue, there's at least a conversation to be had. Let's have it 1/🧵 www.science.org/content/arti... #AcademicChatter
Why I may ‘hire’ AI instead of a graduate student
“It can competently perform a lot of the work I need immediately,” this professor writes
science.org
Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...
We are excited to share our new preprint: iCLIP3 — an improved protocol for transcriptome-wide mapping of protein–RNA interactions at single-nucleotide resolution.
bioRxivpreprint@biorxivpreprint.bsky.social · 7mo agoiCLIP3: A streamlined, non-radioactive protocol for mapping protein-RNA interactions in cellular transcripts at single-nucleotide resolution https://www.biorxiv.org/content/10.64898/2026.03.01.708747v1
Ask your AI assistant how it feels about this! firstmonday.org/ojs/index.ph...
De-anthropomorphizing “AI”: From wishful mnemonics to accurate nomenclature | First Monday
firstmonday.org
An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.
Professors: we must start teaching the creative scientific process to PhD students and postdocs! Register for our April 24 train-the-trainer event in New York to learn from us how to teach it. night-science.org/train-the-tr... Register by Jan. 30th for a free Night Science Podcast T-shirt!
We've got ISSUES. Literally. We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do? arxiv.org/abs/2601.07563 A 🧵 1/n
Attend the 2. RMU-RNA Salon X-mas Meeting to find out your new favourite RNA modification! December 18, 2025, Niederrad Campus, Frankfurt bit.ly/2_Xmas_RMU_R...
