Please check out our new preprint! We find an unexpected role for #CASM in regulating p62 mediated activation of the KEAP1/NRF2 pathway to initiate a cytoprotective antioxidant transcriptional response. More functions for #CASM in responding to lysosome stress. www.biorxiv.org/content/10.6... 1/2

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

Effective lysosome function is essential for health, and declines with ageing and disease. Upon lysosome damage, cells mount a complex stress response to restore homeostasis. Membrane ATG8ylation play...

biorxiv.org

Conference reminder! Abstract submission and early-bird registration to the 93rd Biochemical Society Harden Conference on "Endosomal-lysosomal network dysfunction in neurodegeneration" closes soon on the 1st July. Lots of speaker slots available from submitted abstracts so do come and join us!

Fantastic work by Aakriti Jain @aakritijain.bsky.social in team with Claire Goul and the Laboratory for Genome Research reveals the LASER pathway and its core component TFG as critical for rapid ESCRT-dependent lysosomal membrane repair, pointing to a deep connection with neurodegeneration!

Aakriti Jain@aakritijain.bsky.social · 2mo ago

So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...

New paper, new tool! 🚨 Where a signaling protein lives matters as much as what it does. Our new tool lets you interrogate this one compartment at a time. We built TerminaTOR, a genetically encodable inhibitor that silences mTORC1 at subcellular locations.

'Endosomal-lysosomal network dysfunction in neurodegeneration'. 13 speaker slots for selected posters. Session chair slots. Keynotes, Frances Platt + Volker Haucke. Colworth Medal Ben Ryskeldi-Falcon. Discussion panels + more. SUPER EARLY DEADLINE 1st JUNE 2026. www.eventsforce.net/biochemsoc/f...

'Endosomal-lysosomal network dysfunction in neurodegeneration'. 13 speaker slots for selected posters. Session chair slots. Keynotes, Frances Platt + Volker Haucke. Colworth Medal Ben Ryskeldi-Falcon. Discussion panels + more. SUPER EARLY DEADLINE 1st JUNE 2026 www.eventsforce.net/biochemsoc/f...

New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social. Available now on BioRxiv: doi.org/10.64898/202...

Ennio@amicoennio.bsky.social · 3mo ago

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

On behalf of #TeamTansey we will investigate the role of #immuneaging in the heterogeneity of #Parkinsons and look forward ending #Parkinsons at Indiana University School of Medicine #Neurology & Stark Neurosciences Research Institute with the continued support of ASAP & MJFF lnkd.in/gzRbb95R

Aligning Science Across Parkinson's@asapresearch.parkinsonsroadmap.org · 3mo ago

📢 Unraveling Parkinson’s. Advancing Precision Medicine. New CRN grants in partnership with The Michael J. Fox Foundation for Parkinson’s Research bring together 32 global teams to map the biology of #ParkinsonsDisease and build tools to accelerate discovery. 🔗 Learn more: bit.ly/4ugkfes

My favorite paper in 2026 so far!! Absolutely stunning 🤩

Juan C. Landoni@jclandoni.bsky.social · 4mo ago

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al! link.springer.com/article/10.1...

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal

Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

link.springer.com

Glad to share our new @cp-trendscellbio.bsky.social article! We discuss how repair condensates and lipid domains work together to restore lysosome integrity or deciding if it's time for lysophagy. #Lysosomes #Condensates #DamageSignature #Lipids #Ions Check it out: doi.org/10.1016/j.tc...

Find someone that loves you as much as @dgershlick.bsky.social loves RUSH!! Congrats!!

Journal of Cell Biology@jcb.org · 5mo ago

Stalder, Pereira, @dgershlick.bsky.social et al. @thecimr.bsky.social uncover new regulators of #Golgi-to-plasma membrane transport, showing that a PTPN23-dependent #ESCRT pathway is essential for secretion of membrane & soluble cargoes, including hormones & antibodies. rupress.org/jcb/article/...

Really excited for the upcoming 93rd Harden Conference on Endosomal–Lysosomal Network Dysfunction in Neurodegeneration. The speaker lineup is fantastic and very diverse across membrane trafficking, structural biology, and functional genetics! Especially encouraging ECRs to attend!

Peter Cullen@peterjcullen1.bsky.social · 5mo ago

With Kirsty and Natalie, excited about 93rd Harden Conference 'Endosomal-lysosomal network dysfunction in neurodegeneration'. 1st-4th Sept 2026 in UK. Opportunities for oral presentations selected from posters. 1st June deadline for cheaper registration!!! Come join us. Please, please spread widely.

Quick proteomics question: we want to use an exogenous biotin blocking scavenger for a TurboID experiment. We tried Biolock but is very inconsistent in our hands. Does anyone have another suggestion?

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 6mo ago

Organelle communication networks rewire to support lipid metabolism during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.10.704675v1

Thrilled to share that the first part of my PhD work from @cohenlaboratory.bsky.social lab is now on bioRxiv! www.biorxiv.org/content/10.6... Check out the threads below:

Sarah Cohen@cohenlaboratory.bsky.social · 6mo ago

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

Journal of Cell Biology@jcb.org · 6mo ago

Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/... #CellSignaling

An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...

🙏🙏 to entire team esp co-lead Tim Bartels. So proud of @seppedeschepper.bsky.social brilliant first postdoc who now leads his own at VIB. 🙏🙏🙏to @chanzuckerberg.bsky.social for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!

UK Dementia Research Institute@ukdri.ac.uk · 6mo ago

Could targeting the gut's immune system tackle the early stages of Parkinson's? 🧠 A new study from @soyonhonglab.bsky.social & Tim Bartels (UK DRI at UCL) has revealed how Parkinson’s spreads from the gut to the brain - with the help of immune cells. Read more 👉 www.ukdri.ac.uk/news-and-eve...

🧪 We are excited to share this novel open access paper on Phasor Mixing Coefficient to analyze colocalization, developed by folks @i2janelia.bsky.social and @aicjanelia.bsky.social. This is also the first technical paper jointly published with our sister imaging center @malacridalab.bsky.social!

Excited to share a new story that transformed how we think about membrane domains in the ER! rdcu.be/eR7Cn ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export Wondering what’s so new and exciting? Skytorial below! 1/9

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export

Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...

rdcu.be

Beyond thrilled to share my PhD work out today in @natcellbio.nature.com , uncovering a nanoscale acidic environment around lysosomes that controls their mobility through proton signaling.🥳🥳🥳 Great thanks to my advisors and excellent peers for helping me！ www.nature.com/articles/s41...

DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology

Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

nature.com

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

0/10 🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis www.cell.com/cell/fulltex...

Continuum architecture dynamics of vesicle tethering in exocytosis

Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

cell.com

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

🚨 Exciting news: Ciarán Butler-Hallisse's work on microtuble turnover is out! with help from @harrisonyork.bsky.social 💪 Look at those pretty neurons 👇😀

Christophe 🔬 Leterrier@christlet.bsky.social · 7mo ago

🚨The Neurocyto lab is branching out in our latest preprint! We used tubulin microinjection to directly visualize microtubule turnover in developing hippocampal neurons, demonstrating the presence of in-lattice repair and a selective stabilization in the nascent axon. Check below, or read on 🧵 1/9

The Reck-Peterson lab at Weill Cornell Medicine is seeking a technician or staff scientist to work on Aspergillus projects. Broad background in fungal biology and techniques required. Bioinformatics skills preferred. Find out more at: reckpetersonlab.org.