Help us untangle repetitive genomic variants! 🧬 We’re looking for an undergrad/master's intern (4 months, Spring 2027) with Python & Bash skills to map regulatory sequences in structural variants in the Bernardo Rodriguez Martin lab. Details & apply: tinyurl.com/mtkknphc #TEsky

Happy to share this release of some new long-read genomes in @genomebiolevol.bsky.social! We hope that subspecies-specific, quality genomes will enable better profiling of variation underlying phenotypic differences in Heliconius, mitigating bias from using a relative's genome as the reference 1/3

Genome Biology and Evolution@genomebiolevol.bsky.social · 2w ago

@a-mack-s.bsky.social @evolvwing.bsky.social et al. generate deep-coverage PacBio long-read data from five Heliconius, recovering high genome contiguity, quality, and completeness scores. 🔗 doi.org/10.1093/gbe/evag171 #societyjournal #genome

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Our manuscript on the co-option of TEs as cerebellar CREs is now officially published in @natcomms.nature.com! Huge thanks to @kaessmannlab.bsky.social @marisepp.bsky.social, and @ioansarr.bsky.social for the fantastic collaboration throughout this project! www.nature.com/articles/s41...

Gene regulatory innovations from transposable elements in primate cerebellum development - Nature Communications

The roles of transposable elements in primate brain development remain underexplored. Here, the authors identify transposable elements with ancestral regulatory potential that have been co-opted as ci...

nature.com

Kaessmann Lab@kaessmannlab.bsky.social · 10mo ago

Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models! www.biorxiv.org/content/10.1...

​New article!: The Origins and Evolution of Writing www.annualreviews.org/content/jour... 🧵1/

The Origins and Evolution of Writing

For centuries, scholars have debated the etiology and evolution of writing. The most persistent concerns relate to the relationship between writing and social organization, linguistic structure, and c...

annualreviews.org

"This trimodal platform enables a comprehensive understanding of the relationships among gene expression, morphological diversity, and functional properties of single neurons" www.cell.com/cell/fulltex...

Multimodal imaging of gene expression, morphology, and activity of the same neuron

This study establishes an imaging-based multimodal characterization (IMC) platform to link in vivo activity, whole-brain morphology, and spatial gene expression in the same cortical projection neurons...

cell.com

You can now make chord diagrams in #ggplot2 🎉 Here's a short blog introducing the 'ggchord2' package and showing you how to make chord diagrams 📊 Link: nrennie.rbind.io/blog/chord-d... #RStats #DataViz #RLadies

Chord diagrams in R with ggchord2 – Nicola Rennie

Chord diagrams can be used to show relationships or flows between and within categories. This blog post introduces ggchord2, a new package that makes it possible to create them using ggplto2 in R.

nrennie.rbind.io

How has natural selection shaped admixed human populations in Mexico? Catch Ram Gonzalez-Buenfil's presentation [B337] at #SMBE2026 to find out! June 30 at 6pm @ 2nd floor Arkaden 6 @ramgonzalezb.bsky.social

Very excited to finally share my PhD! 🎉 Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances. Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social! 📄 www.science.org/doi/10.1126/...

Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish

Loss of the conserved splicing factor for neuronal microexons disrupts neuromodulatory signaling and drives hyperarousal.

science.org

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

🎉 #Preprint alert! Excited to share this new study from our postdoc Carsten Hain on centromeres! www.biorxiv.org/content/10.6... This work presents HORoSCOPE, a computational framework that infers centromere architecture and size directly from short-read sequencing data. (1/3)

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

Dual profiling of DNA modifications with enhancer features during the exit of naive pluripotency

Cis-regulatory elements, such as enhancers, play an essential role in coordinating gene expression programs during cellular transitions. As such, substantial efforts have been made to characterize enh...

biorxiv.org

Mafalda Dias es finalista del premio Vanguardia de la Ciencia. Su línea de investigación está ayudando agilizar el diagnóstico de enfermedades raras, ofreciendo una evidencia adicional para médicos que ya tienen sospechas sobre ciertos genes implicados según los síntomas. ¡Vota ahora!

“Diagnosticamos enfermedades raras analizando millones de años de evolución”

Vota a las finalistas del premio Vanguardia de la Ciencia

lavanguardia.com

Contribution from the REPBIO team at @crg.eu (Layla Diaz, @jemilianosf.bsky.social, and myself) to the Volume 116 of Advances in Genetics, on Transposable Elements in Health and Disease, edited by @epiageing-lab.bsky.social sciencedirect.com/science/chap... [1/5]

#TEsky

Bernardo Rodríguez Martín@bernardo-rodriguez.bsky.social · 2mo ago

📢📢 Job opening between the Bioinformatics Unit and my group (REPBIO) at @crg.eu Interested in contributing to our efforts to leverage long-read sequencing technologies for human genome research? Join us in Barcelona: recruitment.crg.eu/content/jobs... Please repost😊

📢📢 Job opening between the Bioinformatics Unit and my group (REPBIO) at @crg.eu Interested in contributing to our efforts to leverage long-read sequencing technologies for human genome research? Join us in Barcelona: recruitment.crg.eu/content/jobs... Please repost😊

Martinez-Ugalde et al. used comparative transcriptomics to show that argonaute protein exWAGO is part of an evolutionarily conserved pathway for LTR retrotransposon regulation. 🔗 doi.org/10.1093/gbe/evag117 🖌️ Laura Fabiola Espinosa Juárez / Isaac Martinez-Ugalde #genome #evolution #celegans

Comparative transcriptomics reveals an extracellular worm Argonaute as an ancestral regulator of LTR retrotransposons academic.oup.com/gbe/advance-...

Comparative transcriptomics reveals an extracellular worm Argonaute as an ancestral regulator of LTR retrotransposons

Abstract. Safeguarding the genome from non-self elements is essential for development, reproduction, and ageing. One of the major threats to genomic integr

academic.oup.com

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬 Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15 www.biorxiv.org/content/10.6...

Recursive Repeat Extender (RRE): A recursive approach to automatically extend repeat element models https://www.biorxiv.org/content/10.64898/2026.04.14.718546v1

PREPRINT ALERT🚨➡️Genetics influencing #epigenetics: Flanking DNA sequences influence #DNAmethylation maintenance 🧬 It’s been a minute because I needed a media break 🧘🏻‍♂️, but I couldn’t resist popping back for this: We just dropped a new #bioRxiv preprint 😃🤞🏻 BTW I’m looking for (academic) jobs

bioRxiv Genomics@biorxiv-genomic.bsky.social · 4mo ago

Flanking DNA sequences determine DNA methylation maintenance in proliferation, cancer and aging https://www.biorxiv.org/content/10.64898/2026.04.09.717557v1

Today in @science.org: We are pleased to present our last work entitled: "Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis" by Zumalave et al. www.science.org/doi/10.1126/...

Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis

LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

science.org

The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...

Nuclear speckles enable processing of RNA from GC-rich isochores

Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increase...

cell.com

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...

Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

nature.com

How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 6mo ago

A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1

New paper! From Sam Snodgrass and @genomeofforrest.bsky.social, w/ @druncie.bsky.social, @gcbias.bsky.social, and a collaboration with Andres Moreno and @santiagogmm.bsky.social. Can we quantify the impact of humans on maize dispersal? Plant yourself in a comfy chair and lend me your ear: 1/10

New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos. www.biorxiv.org/content/10.6...

Our paper on clinically relevant genetic variation in the MX Biobank is out today in Nature Medicine! Big congrats to PhD student Carmina Barberena, who led the development of the MexVar platform. A joint effort by Cinvestav, INSP, INCMNSZ, LIIGH, UNAM, and UCSC www.nature.com/articles/s41...

Clinical genetic variation across Hispanic populations in the Mexican Biobank - Nature Medicine

Analyzing data of the Mexican Biobank project, a new study finds regional differences in clinically relevant genetic frequencies and presents MexVar, a publicly accessible resource designed to support...

nature.com

🧬 Pot una IA predir mutacions perilloses del teu ADN?  🤖 PopEVE detecta noves mutacions comparant proteïnes humanes amb dades evolutives de milers d’espècies per identificar les que poden causar malalties greus. @crg.eu  👀Llegeix-ho aquí.

Un model d'IA revoluciona el diagnòstic de malalties minoritàries - El·lipse

Investigadors del CRG han col·laborat amb un equip de Harvard per desenvolupar popEVE, una eina d'intel·ligència artificial que ha estat capaç de detectar 123 noves mutacions causants de malalties; 104 d'elles s'han observat només en un o dos pacients.

tuit.cat