This was a super team project with Rebecca Morse-Mora, the Peter Jonas lab and scientific services at @istaresearch.bsky.social, enabled by our fantastic collaboration with Prof. Karl Rössler at the @meduniwien.ac.at. We still have a lot to learn about hippocampal function and #humancircuits!! 🔎

Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans

Associational memory is critically dependent on the CA3 recurrent circuit, at the centre of the hippocampal system. While diversity amongst CA3 pyramidal neurons (PNs) has been long reported, the prin...

doi.org

Very happy to share our new review on visual computation in the cephalopod brain, with @vangeliqueallen.bsky.social, out now! We discuss exciting recent advances in understanding how the radically different brain of cephalopods processes the visual scene. 🐙🔬👀 www.sciencedirect.com/science/arti...

***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social

Generative replay across hippocampal-neocortical circuits

To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...

biorxiv.org

Prior experience dynamically determines differential cue weighting in the medial entorhinal cortex

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2w ago

Prior experience dynamically determines differential cue weighting in the medial entorhinal cortex https://www.biorxiv.org/content/10.64898/2026.07.22.739574v1

We wrote a French digest for médecine/sciences about our recent work in Nat. Neuro with @nicolasguyon.bsky.social Original work: www.nature.com/articles/s41... French piece: www.medecinesciences.org/fr/articles/...

Help needed! I'm part of a team tasked with creating a 2nd year undergraduate module/course "Computational Skills for Psychologists" Its remit is the fundamentals of coding and good practice. Any advice from others who've done similar courses? (Assume no programming knowledge. Assume Python)

A neat description of @agnesland.bsky.social 's discovery. (I wish I could write as clearly as @ericaklarreich.bsky.social)

Simons Foundation@simonsfoundation.org · 2w ago

Neuroscientists have long wondered exactly how brain activity relates to blood flow. A new paper from the Simons Collaboration on the Global Brain suggests the answer lies in a hidden balance between two opposing groups of neurons. Read more: https://bit.ly/3QX90to #science #neuroscience

Is space & time coding in entorhinal cortex interchangeable? Cells switching between space & time as needed by task? For some cells yes, and other no: Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex www.biorxiv.org/content/10.6...

The latest result from a fun ongoing collaboration! @mbeyeler.bsky.social @michaelgoard.bsky.social @spencerlaveresmith.bsky.social

Spencer LaVere Smith@spencerlaveresmith.bsky.social · 3w ago

Ecological Visual Processing in the Mouse - with @michaelgoard.bsky.social @crisniell.bsky.social @mbeyeler.bsky.social Visual computations that are engaged in ecological contexts: active sensing, motion processing, scene analysis, distance estimation, and spatial perception. doi.org/10.1146/annu...

Thank you Natalia Mesa at the @thetransmitter.bsky.social for highlighting our labs preprint on synaptic mechanisms of head direction learning!! 🪰🧭 Work from @markplitt.bsky.social in my lab in collaboration with the Jayaraman lab! www.thetransmitter.org/learning-and...

Unique learning mechanism drives navigation in fruit flies

The neuromodulator octopamine, the insect counterpart to norepinephrine, helps flies get their bearings in an unfamiliar environment.

thetransmitter.org

Our work on goal-directed theta sweeps is out! We found two different types of theta sweeps in the rat hippocampus. During random foraging, left-right alternating sweeps dominated (Vollan, 25). However, during memory-guided navigation sweeps pointing to hidden goal locations emerged with learning.

We'll be showing off our new Modular Operant Chamber on the RWD table (#132) at FENS - come check it out! aquineuro.eu/produits/mod... Key details - Behavior chamber for operant conditioning and more - Supported by custom, easy-to-use software - Modular design with customization possible

Excited to share our new paper: "The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice,". Out now in @cp-iscience.bsky.social 🧵1/9 www.cell.com/iscience/ful...

The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice

Biological sciences; Behavioral neuroscience; Laboratory animal science

cell.com

Is spatial navigation innate 🧠? Using #NeuroPixels we show that the #torus 🍩 underlying the #GridCell map exists already on day 10 in rats — before pups open eyes and ears and before they start upright walking. 🧵1:4 👇 www.biorxiv.org/content/10.6...

Ever wondered how the hippocampal cognitive map is read-out? @changmin-yu.bsky.social @zilong-ji.bsky.social with Jake & John, show that, during navigation, theta sweeps indicate remembered goal-directions (cf. current/next movements or perceptual targets) 1/2 www.nature.com/articles/s41...

🐜 only follow nest plumes when their nest is in close vicinity according to their path integrator. www.cell.com/iscience/ful...

Context-dependent influence of path integration on nest plume following in desert ants

Entomology; Biophysics; Complex systems

cell.com

www.cell.com/cell/fulltex...

Arc mediates intercellular tau transmission via extracellular vesicles

Tau pathology spreads cell to cell in Alzheimer’s disease, but the molecular mechanisms are unclear. This study found that the capsid-forming protein Arc binds and packages tau into extracellular vesi...

cell.com

A little late to announce it, but I'm very happy to have contributed to this article ! If you LOVE electrophysiology, this is for you ! www.frontiersin.org/journals/cel...

Frontiers | Early and transient increase in cortical pyramidal cell excitability and delayed alteration of evoked synaptic transmission and t-SNARE proteins content in the hippocampus and neocortex of...

De novo mutations in the Stxbp1 gene lead to Munc18.1 haploinsufficiency and are a major cause of neurodevelopmental disorders. Because Munc18.1 is essential...

frontiersin.org

🧠 Sarah Mondoloni | FENS-EJN Awards Lecture 🌟 At #FENS2026, join Sarah Mondoloni on 6 July! 🔬 Sarah Mondoloni is a neuroscientist at the Institut de Neurobiologie de la Méditerranée (INMED) in Marseille, France. Meet all the speakers 👉 buff.ly/wQ8V4Ha @ejneuroscience.bsky.social

Our paper is now in print in Nature @nature.com. If you're interested in local field potentials, especially #high-gamma activity, and/or #spikes, check it out! TL;DR: High gamma is not mainly filtered spikes, but mainly summed nearby PSPs. www.nature.com/articles/s41...

Active dissociation of intracortical spiking and high gamma activity - Nature

A brain–machine interface is used in monkeys to investigate the biophysical underpinnings of cortical high gamma-band activity, a signal that is often studied in the context of many brain functions.

nature.com

Less than two weeks to register for the ion channel meeting. Please RT!

Laetitia Mony@laetitiamony.bsky.social · 2mo ago

Only 2.5 weeks left to register to the Ion Channel meeting that will take place in September in Sète (France)! Whether you want to connect with the #Ionchannel community or extend your summer on the Mediterrean sea (or both!), this conference is for you. Registration deadline July 3rd. Pls share!

Really excited about this work with the awesome Will de Cothi & @shipleysj.bsky.social, out in Nature Reviews Neuroscience. We propose acetylcholine is an analogue of dopamine — tracking not reward prediction errors but state-transition prediction errors. https://doi.org/10.1038/s41583-026-01058-w

It’s Moussaka for dinner tonight !

A study in Nature Neuroscience shows that core benefits of sleep—reduced local sleep pressure, renormalized synaptic strength and memory consolidation—can be reproduced in awake, behaving mice by inducing sleep-like on/off activity patterns in cortex. #Neuroskyence 🧪

Induction of cortical on/off periods in awake mice fulfills sleep functions - Nature Neuroscience

Driessen et al. show that core benefits of sleep—reduced local sleep pressure, renormalized synaptic strength and memory consolidation—can be reproduced in awake, behaving mice by inducing sleep-like on/off activity patterns in cortex.

go.nature.com

Deadline day! We are almost full... www.biologie.hu-berlin.de/en/groupsite...

Andrew Plested@andrewplested.bsky.social · 3mo ago

Very pleased to announce the 3rd Berlin Single Molecule Biophysics Course, this September 14th-18th. We now include more single molecule microscopy, with @ewerslab.bsky.social and Maximillian Ulbrich joining Jelena Baranovic and Claudio Grosman as tutors. Apply @ bsmbc@icloud.com by 12th June!

Always nice to receive a hard copy of a textbook you contributed to and not always the case I find the cover’s illustration beautiful thanks Nicolas Wanaverbecq, @ianduguid.bsky.social and Annalisa Scimemi for huge editorial work

Be still my beating heart! Super interesting and important. The Mosers show that when rats switch between familiar rooms, each grid module shifts phase independently — and that differential shift across modules drives global remapping in hippocampal place cells. 🔗 doi.org/10.1101/2025.09.24.677985

Beautiful view from the beach in Cassis this morning

Ever wonder how your brain navigates the real world? 🧠 Most spatial navigation studies use flat, 2D mazes. But the real world is hilly, irregular, and bumpy! ⛰️ Our new paper in #ScienceAdvances asked a simple question: How does the brain map uneven terrain? 📄 doi.org/10.1126/scia... 🧵👇️️️ 1/

Hillscape cells: Hippocampal place cells map terrain geometry independently of behavior #neuroskyence @roddy-grieves.bsky.social Eleonore Duvelle and Jeff Taube: www.science.org/doi/10.1126/...

Hippocampal place cells map terrain geometry independently of behavior

Place cells map terrain geometry, not behavior, revealing a surface-based brain code for real-world navigation.

science.org