Jess Kelley
@jesskelley.bsky.social
Postdoc with Dominika Gruszka at the University of Oxford. Previously DPhil student in the Klose lab. Interested in the molecular mechanisms of chromatin-based processes. She/her
In addition to being an excellent scientist, @aleksszczurek.bsky.social is an extremely talented watercolour artist. I've finally got this beautiful painting back from the framer and up on the wall in pride of place! The scene is from a photo I took on a rather changeable day in Glenmalure, Ireland.
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Just returned from an incredible 3-day multi-lab retreat with the teams of Daniele Fachinetti, Nick @naltemose.bsky.social, and Dominika Gruszka in Pêra, Portugal. Sunshine😎, great company 🤗 and fantastic centromere and chromatin science 🔬! Thanks to all the teams for this wonderful gathering!
Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you! 1/n
Job Details
my.corehr.com
I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!
Anders Sejr Hansen@andersshansen.bsky.social · 6mo agoExcited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...
Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social
FragileNucleosome@fnucleosome.bsky.social · 7mo ago🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
Unbelievably, #DuvetKnowItsChristmas generates such good will on social media that over the years we've raised somewhere approaching a quarter of a million quid for homeless charities. If you can spare a bob or two, sling some to Centrepoint, and here's the link: www.gofundme.com/f/duvet-know...
Donate to Duvet Know It's Christmas, 2025, organized by Rhodri Marsden
Unbelievably, it's the 15th year of this thing. What is it? Improbably, the nig… Rhodri Marsden needs your support for Duvet Know It's Christmas, 2025
gofundme.com
This year I'm hosting Christmas in my 1-bed flat. My brother has inherited last year's airbed setup and I've upgraded to an actual bed! Just a (freezing) 10-minute cycle down the road to my friend's house to get to it... I get to hang out with Imogen though so I'm still happy #DuvetKnowItsChristmas
Jess Kelley@jesskelley.bsky.social · 2y agoI finally get to join an honoured festive tradition in #DuvetKnowItsChristmas Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor. Also featuring camping chair to supplement my 2-seat sofa
Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
biorxiv.org
Very proud to have our latest work now online in @natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4 www.nature.com/articles/s41...
Heterochromatin boundaries maintain centromere position, size and number - Nature Structural & Molecular Biology
Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.
nature.com
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 20/31 Prompt RIVALS Pdb: 8V27 & 8G6S Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them. Next: BLAST Suggestions?
Time to talk about one of my favourite Oxford buildings, 26-27-28 Cornmarket!! Popularly known as The Old Pret
ellen@elfenzo.bsky.social · 11mo agoAre there any heritage Gregg's or McDonald's? I find it fascinating when they make corporate an old, old building
If you're looking for Oxford local news that actually reports local news, the Oxford Clarion is worth a follow and subscribe!
Oxford Clarion@oxfordclarion.bsky.social · 11mo agoOxfordshire’s weekly news update with all the stories we’ve broken this week: ✅ 10,000-home new town in North Oxfordshire ✅ Why Oxford–Milton Keynes trains haven’t started ✅ The new café run by monks ❌ Cotswold celebrities and Emma Watson Read it online or by email: oxfordclarion.uk/clarion-week...
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
Research @oxfordbiochemistry.bsky.social @ox.ac.uk supported by the Wellcome Trust (UK) and NIH (USA) reveals essential new player in the process of deciding whether genes should be made or not. Great work @jesskelley.bsky.social @robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose
Unlocking the Pause: A new player in gene transcription
A new work from the Klose lab published in the journal Molecular Cell
bit.ly
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users? Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT More info: www.ucl.ac.uk/ucl-east/new...
So I'll be back around then. We'll be trying to raise a bit of money for Centrepoint, bearing in mind that there are a bunch of people who have nowhere to go this evening. gofund.me/637d21d0 ENDS FOR NOW 🎄🛏️
Donate to Duvet Know It's Christmas, 2024, organized by Rhodri Marsden
Unbelievably, it's the 14th year of this thing. What is it? Improbably, the nig… Rhodri Marsden needs your support for Duvet Know It's Christmas, 2024
gofund.me
I finally get to join an honoured festive tradition in #DuvetKnowItsChristmas Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor. Also featuring camping chair to supplement my 2-seat sofa
We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
Join Oxford Biological Physics! #KavliOxford is inviting applications for Fellows to establish independent research groups in this dynamic, interdisciplinary field. Apply now: kavli.web.ox.ac.uk/article/2025...
2025 Application Round for Fellows in Oxford Biological Physics
kavli.web.ox.ac.uk
Turns out that, for me, news sites are a great way to become usefully informed about what's happening in the world, and Twitter is a great way to get uselessly stressed about it.
Nice thread collating all these exciting new reviews! My 'to read' list has definitely just got even longer...
Craig Kaplan@triggerloop.bsky.social · 2y agoAs you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...
This paper is genuinely amazing! Not only is the science very cool, it is also a masterclass in scientific writing, as are most @robklose.bsky.social lab papers!
Jess Kelley@jesskelley.bsky.social · 2y agoVery excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
