Jo Poole

@jopodr.bsky.social

Anaesthesia. ICM. Mitochondria. Evolution. Once slept in a museum.

Interesting biomarker for 24 hour and 28 day mortality in critically ill patients (reflects metalloproteinase tissue damage and angiotensin II activity). AUC 0.83 for 24 hour. Interestingly subgroup with elevated biomarker & ACEi use higher mortality ccforum.biomedcentral.com/articles/10.... #emimcc

Value of cDPP3 as a short-term prognostic biomarker in all-comers critically ill patients in the emergency department - Critical Care

ccforum.biomedcentral.com

Use of Intralipid in a Propranolol/Quetiapine induced cardiac arrest - our poster today at #SOA25 Evidence for lipid rescue is (and will likely remain) limited, but it really was an inspiring and uplifting case to have been a part of - ROSC after 76 mins CPR and an excellent neurological outcome.

Bild

My family had a recent experience of hospital care & we saw effect of this type of taskification of care. Pointless delays, miscommunication, unnecessary referrals etc. No one had the patient at the core of their thinking as they did their bit of the job - result was real anguish

Shaun Lintern@shaunlintern.bsky.social · last yr.

"For too long, we have trained ‘to role’ - often requiring individuals to complete years of training - when many tasks can be carried out with good supervision."

These cuts come as high-ranking US officials criticize top journals as ‘woke’ and ‘corrupt’. In May, RFK Jr threatened to bar government scientists from publishing in top medical journals. And several journals received letters in April from DOJ alleging political bias in the research they publish.

Once again, this is why we cannot ask pregnant trainees / early career faculty to attend scientific & medical conferences in states that outlaw abortion, and hence why we absolutely must not hold conferences in these states

ProPublica@propublica.org · last yr.

NEW: More women have nearly bled to death during miscarriage under Texas’ abortion ban. Experts say the trend paints a troubling picture of the harms of unnecessary delays in care. “This is striking,” one doctor said. “The trend is very clear.”

These are war crimes, missile attacks in areas full of defenceless civilians and children are pathetic - why is there so much inaction on the atrocities being committed by the IDF? We wouldn’t tolerate other nations doing this? www.theguardian.com/world/2025/j...

Witnesses describe grim aftermath of Israeli strike on busy Gaza cafe

Women, children and elderly people among at least 24 killed by attack that turned beach spot into scene of carnage

theguardian.com

the volume of an ellipsoid is ABC/2 so if a patient is in hemorrhagic shock with an 3x4x5 cm hematoma in their abdomen, the hematoma *cannot* explain their hemorrhagic shock (estimated 30 cc volume) keep looking for the source of bleeding (which statistically is likely to be a GI bleed) #EMIMCC

BildBild

I've been diving into evidence on Covid vax in pregnancy & sorting through misinformation, incl the claim Pfizer never reported on its pregnancy trial. I ended up relieved! Check out studies in >1.5 million vaxed pregnant participants in my latest @plos.org absolutelymaybe.plos.org/2025/06/27/d...

Digging Into the Evidence on Covid Vaccines in Pregnancy - Absolutely Maybe

Decision-making about drugs in pregnancy can be very difficult. Our illogical aversion to clinical trials in pregnancy means people making particularly complex…

absolutelymaybe.plos.org

The vaccine situation in US government is depressing. Watching a successful (of course imperfect) nation disassemble itself is eerie. What has brought that into being and how do we prevent that in Europe?