Pablo Alcón
@palconh.bsky.social
Scientist. Molecular and structural biology of DNA repair 🧬 Aarhus University 🇩🇰🇪🇺 From Extremadura, Spain 🌍 https://sites.google.com/view/alconlab/home
🚨 Preprint alert 🚨 Excited to share our latest bioRxiv preprint introducing DeepDiffusion, a tool for analysing facilitated 1D diffusion! 🔗 Preprint: www.biorxiv.org/content/10.6... (1/3)
DeepDiffusion: a Physics-Informed Neural Network for Heterogeneous Facilitated 1D Diffusion
Single-molecule fluorescence microscopy combined with optical tweezers has enabled the direct observation of diffusing proteins on tethered DNA. These and complementary techniques reveal facilitated o...
biorxiv.org
🔬 Your tax dollars once paid a physicist whose own colleagues told him he was wasting the university's money. In 1951, Charles Townes sat on a D.C. park bench and worked out, on the back of an envelope, how to force molecules to release coherent radiation. 🧵 1/5
🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92
Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
Join us! Postdoc position (2-3 years) in our lab @molbiolau.bsky.social Looking for candidates with experience in cell culture, genome editing, biochemistry, and/or structural biology. Application opens in August via AU's system but informal enquiries by email are welcome from now. (1/2)
The first paper from my postdoc, looking at how tension activates DNA cleavage by the endonuclease ANKLE1, is out in @narjournal.bsky.social. ANKLE1 processes ultrafine bridges, persisting linkages between chromosomes that can lead to catastrophic DNA ruptures. (1/3) doi.org/10.1093/nar/...
How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: https://www.nature.com/articles/s41586-026-10650-0
Back in the lab with lots of energy and ideas after #Machinesongenes ⚙️🧬 @biochemsoc.bsky.social in beautiful Crete 🇬🇷 🐈 Besides the amazing science, it was wonderful to meet so many friends. A special highlight was this Passmore-lab mini-reunion:
📢 ¡Anunciamos el Simposio "The Structure and Working of Molecular Machines" Más información en: biophysal.org/symposium/ #BioPhySal #SomosLUMES #USAL #MolecularMachines @usaloficial.bsky.social @ibfg.bsky.social @csiccyl.bsky.social @ciccancer.bsky.social @irnasa.bsky.social
🧬 Charlotte (Lotte) Auerbach, born on this day in 1899, was the 1st scientist to prove that chemicals could cause genetic mutations in living organisms. After fleeing Nazi Germany to Edinburgh, her work with fruit flies 🪰 & mustard gas ☢️ transformed modern genetics & cancer research. #WomenInSTEM
This should be a good one, don't miss it!
📢 External seminar at the IBFG! 🥼Talk by Dr. David Rueda - @imperialcollegeldn.bsky.social (London, UK) 🔬Topic: Dynamic Control of Chromatin Architecture and DNA Resolution 🗓️ May 15, 2026 – 12:00 PM 📍 IBFG Auditorium, Salamanca
Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇
www.theguardian.com/tv-and-radio...
Happy centenary, David! Attenborough’s 100 most spectacular TV moments
He has been besieged by birds, had 120m crabs try to crawl up his trouser leg and stayed cool beside an erupting Icelandic volcano. As David Attenborough turns 100, we celebrate his most extraordinary...
theguardian.com
Paper alert 📣 Our group has just published a new review in Biochemical Society Transactions on emerging functions of STIM1, expanding its role beyond its classical function as an ER Ca2+ sensor. We discuss new insights into its involvement in key cellular processes portlandpress.com/biochemsoctr...
Unraveling new functions of the Ca2+ sensor STIM1 in cell signaling
Abstract. Calcium (Ca2+) signaling is a fundamental regulator of virtually all aspects of eukaryotic cell physiology, including gene expression, secretion, metabolism, motility, and cell fate decision...
portlandpress.com
It's already back ???? #Maythe4thBeWithYou #MayThe4th #MayTheFourthBeWithYou Well, somebody has to do it @nucleosomepolice.bsky.social 🫣 poke @markhamillofficial.bsky.social Did you know that the nucleosome inspires the Millennium Falcon design and made the Kessel Run in less than 12 parsecs ?
Happy Birthday to Santiago Ramón y Cajal - the "father of modern neuroscience."
a man in a suit and tie is talking to a man in a uniform .
ALT: a man in a suit and tie is talking to a man in a uniform .
media.tenor.com
When we met online it said it was a haddock. It was only after we were married I found out the truth. www.bbc.co.uk/news/article...
Congratulations to @lapassmore.bsky.social, Joint Head of the LMB’s Structural Studies Division, who has been elected an international member of @nationalacademies.org Congratulations to #LMBalumni Andrea Brand who has also been elected. Read more: mrclmb.ac.uk/news-events/... #LMBNews
New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...
doi.org
🕛🕔🕗 Heads up! Fragile Nucleosome Seminar is at a special time this week: 2pm US West / 5pm US East / 10pm UK / 6am Tokyo / 7am Melbourne We'll have outstanding talks on chromatin from Shabih Shakeel and @kazu-maeshima.bsky.social !!! register here: us06web.zoom.us/webinar/regi...
Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
2nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
Wake up, kids We got the dreamers disease. ‘Radical’ comes from a Latin word meaning "root." Because roots are the deepest part of a plant, ‘radical’ came to describe things understood as fundamental or essential. ‘Radical change’ was a change at the root of a system.
Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!
phd.nat.au.dk