Julia Bauman
@juliabauman.bsky.social
PhD student at @ Stanford, Steinmetz Lab Explaining cool new biotech to the world via TikTok/X
Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/
An encyclopedia of human enhancer–gene regulatory interactions - Nature
An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...
nature.com
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
nature.com
Oh hey, looks like I can upload longer videos here now! Here’s my most recent one covering the latest findings on ecDNA retention mechanisms from the Chang & Mischel labs.
Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction.
More updates on what’s happening to federally funded US science. Roughly the same magic touch Trump has brought to world trade, actually. Today’s examples are on drug-resistant gonorrhea and vaccine approvals, both of which are going to hell.
The Continuing Crisis, Part XI: Feral Children, Breaking Things
science.org
Any scientists want to help with a science communication project? Will reach thousands on TikTok! Details⬇️
www.nytimes.com/2025/04/03/o... Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security
Opinion | The Uncertain Fate of the Young American Scientist (Gift Article)
Young researchers are choosing between staying in science and staying in the United States.
nytimes.com
Gee, I wonder what that study on vaccines and autism will show www.washingtonpost.com/health/2025/... "Geier and his father, Mark Geier, have published papers claiming vaccines increase the risk of autism, a theory that has been studied for decades and scientifically debunked."
Interesting panelist discussion at #KSTumorMetab25 on communicating science effectively to combat misinformation in this era. Check out this #WorldView that we, @natrevcancer.bsky.social, published from @juliabauman.bsky.social who posts 60-second TikToks explaining recent papers. bit.ly/41trLps
Maximize your research impact with storytelling - Nature Reviews Cancer
Although sometimes overlooked, storytelling is a powerful tool for communicating scientific research. In this World View, Julia Bauman outlines what is needed to convey a strong scientific narrative, ...
nature.com
I know Twitter sucks but it’s a *great* time to try to spread messages about harms to US science to non-academics
Glad to see this post getting some traction, because the Federal Register is the WHOLE ballgame, folks. To drive this point home, a recent EO declares that all posts to FR now must be approved by the White House. www.whitehouse.gov/presidential...
Ensuring Accountability for All Agencies
By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered:
whitehouse.gov
Dr. Becca@docbecca.bsky.social · 2y agoIf the block on the Federal Register isn’t removed in the next few months, I fear a majority of labs will close within a year. This small procedural wrench has the power to kill US science indefinitely, losing an entire generation of discovery and innovation.
I have had a TON of people asking how they can help...here is what would help us the most right now: SHARE SHARE SHARE SHARE SHARE! Tell us why you #standupforscience2025! Send flyers to your colleagues and labs! Change your bluesky banner! Tell your professional orgs and departments!
Cuts to the NIH are a strategy to strangle research universities not “reduce waste”
It is indeed my understanding that most research institutions won't survive if this is implemented. I know I will contact my congress and senate members. 5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
5calls.org
Rick Huganir@rhuganir.bsky.social · 2y agoThis is the end of science as we know it if it stands—15% IDCs for all NIH Grants. grants.nih.gov/grants/guide...
Insanely good news if this holds up. Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor www.science.org/doi/10.1126/...
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts...
science.org
Took me 3 minutes to call both of my Senators and my representative. Just do it.
Jeremy Stanley@jstanley0.bsky.social · 2y agoI hate phone calls, and I have GOP reps, but I made the calls: "It's unconstitutional--Congress has the power of the purse. I urge Senator Curtis to oppose this power grab. Even if he agrees about certain funds, it's not worth abandoning the checks and balances at the foundation of our republic."
Our paper is out!! TLDR; Cell Painting as a phenotypic readout in whole-genome CRISPR screens is very informative, cheap per cell, & we find some interesting biology!
JT Neal@jtneal.bsky.social · 2y agoOur paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41... (I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)
Dying for a bookmark function on @bsky.app! How else am I supposed to add to my massive list of unread papers 😰
www.biorxiv.org/content/10.1... Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...
I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...
Plant Biology Exploratory Research Microgrant | Experiment
For Science!
experiment.com
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap
If the idea of an RFK Jr. HHS Secretary (or any of the other scientific/medical agency appointees) is concerning to you, contact your senators to express your worries. Feel free to borrow my template below:
I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:
Distinguishing real from invented problems with the NIH
How does the NIH work and where does it work well?
open.substack.com
Impressive study from Alex Stark lab identifying 3 new types of silencer elements in Drosophila New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene www.sciencedirect.com/science/arti...
Good news: You can post video on Bluesky now! Bad news: Only up to 60s. So here’s a clipped version of my latest video about a paper exploring the landscape of possible molecular glue degradation targets:
How did I just find out that Nature publishes weekly sci-fi stories?! is this news to anyone else or am I just way behind
Not being able to post video largely defeats my purpose for being here but it also makes my browsing experience better… I feel conflicted by this🙃
