WARNING! TACO BELL ADVISES NEW TACO SO GOOD IT IS BEYOND THEIR CONTROL, COULD REPLACE ALL OTHER FOOD BEFORE HUMANS CAN CONTAIN IT. URGES CONGRESS TO GIVE THEM MORE MONEY SO THEY CAN DEVELOP ANTI-TACO SAFEGUARDS

Together with Hans Bjornsson (and @kasperdhansen.bsky.social, and others) we have spent many years thinking about the molecular basis of Mendelian disorders caused by variants in chromatin regulators. We have written a review where we discuss our thoughts: www.tandfonline.com/doi/full/10....

Mendelian disorders of the epigenetic machinery: a decade of insights into the molecular basis

The Mendelian disorders of the Epigenetic Machinery (MDEMs), or Chromatinopathies, are now understood to be a collectively common cause of childhood neurodevelopmental delays and intellectual disab...

tandfonline.com

We need to think bigger for our Project 2029. Current Democratic efforts don't rise to the challenge. Worth reading this column by @jamellebouie.net even moreso than usual.

Will Bunch@willbunch.bsky.social · 2mo ago

This may be @jamellebouie.net 's best column ever, which is really saying something. Here's a gift link www.nytimes.com/2026/06/03/o...

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

11. Addendum: here are the words characteristic of LLMs. Notice anything? It reads like an email from our upper administration.

Absolutely phenomenal infrastructure work by Dirk, one of the giants of the R community. This kind of work is of high importance, but (usually) does not get the recognition it deserves. Thank you for your continued commitment to excellence.

Dirk Eddelbuettel@eddelbuettel.com · 2mo ago

Everybody likes a round number -- and #r2u just surpassed eighty million #Ubuntu binaries shipped. All carefully crafted via GitHub Actions from #RStats CRAN packages. #r2u: Fast. Easy. Reliable. Pick All Three.

As I read it, there are some big changes sneaking into this notice.

I-75 Scientist@flscitriguy.bsky.social · 2mo ago

NIH Definition of Foreign components. grants.nih.gov/grants/guide...

Excited to see this preprint out from the lab! Congrats to @heinarsson.bsky.social, Natsuda, @robertkrautz.bsky.social, and all co-authors involved in this major effort on developing nucCAGE and PRIME, and on evaluating transcription initiation-defined regulatory elements for variant interpretation!

Robert Krautz@robertkrautz.bsky.social · 3mo ago

Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”. www.biorxiv.org/content/10.6... We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.

Really interesting critique of a paper in Science. By now it is well established that you need to compare to simple baselines before making big claims.

William DeWitt@wsdewitt.github.io · 3mo ago

Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis. Preprint (w/ Gian Marco Visani and Aayush Verma): www.biorxiv.org/content/10.6... Blog: dewitt-lab.github.io/posts/2026-0...

🚀 We’re excited to share the release of Bioconductor 3.23, featuring: ✅2418 software packages (94 new) ✅437 experiment data packages (5 new) ✅928 annotation packages ✅8 books (2 new) ✅28 workflows 🔗 Please see the full release announcement here: bioconductor.org/news/bioc_3_...

JPAI expresses concern that AI will generate even more papers than he does. 😜

this truly excellent. Having lost Tanya 3.5 years ago, my father a few weeks ago, and my dog last week (not kidding), this is timely

PhantomStrider@phantomstrider.bsky.social · 5mo ago

Holy crap this was so from the heart it almost made me tear up. Andrew Garfield didn't feel for a single moment like he was acting or talking down to Elmo. Had no doubt he meant every single word he said. www.youtube.com/watch?v=EVlX...

This is really impressive.

Páll Melsted@pmelsted.bsky.social · 5mo ago

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result

Current NIH leadership want you to think they are using rigorous, consistent & scientific processes to screen studies to align them with agency priorities. But the process that they have put down on paper is a sham. It’s important to know NIH is not following its own guidance. Here’s why: 🧵1/

🧬 New from @leandrosboukas.bsky.social & co 📄Identification of de novo variants from parent-proband duos via long-read sequencing 🖥️ github.com/sbergercnmc/...

Identification of de novo variants from parent-proband duos via long-read sequencing

Determining de novo status is often what upgrades a variant from VUS to pathogenic, but it has not been possible without sequencing both biological parents. We developed, extensively evaluated, and ap...

cell.com

The ultimate goal of wellness consumerism is to shift all responsibility to the individual health consumer who then gets the "freedom" of navigating an unregulated snake oil market.

Michelle Cohen@docmcohen.medsky.social · 5mo ago

Anyway, I want to thank these guys for gifting me with the perfect screenshot to end this 🧵 on. Truly a chef's kiss of a picture worth 1000 words. My eternal gratitude for this gem.

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free

Bruce Springsteen - Streets Of Minneapolis (Official Audio)

YouTube video by Bruce Springsteen

youtu.be

Glad to share our benchmark study in Genome Biology on highly variable gene (HVG) selection methods for single-cell RNA-seq. We show that a hybrid strategy performs best, now implemented in the mixhvg R package. rdcu.be/eUfjt

Gift link, probably the funniest thing the Wall Street Journal has done this year.

We Let AI Run Our Office Vending Machine. It Lost Hundreds of Dollars.

An AI agent ran a snack operation in the WSJ newsroom. It gave away a free PlayStation, ordered a live fish—and taught us lessons about the future of AI.

wsj.com

This is shocking stuff. John Quackenbush has been brilliant since forever. www.statnews.com/2025/12/05/r...

His lab was humming with discovery. After one year under Trump, it’s almost silent

John Quackenbush built a lab that is at the forefront of human genetics research and bioinformatics. Trump administration cuts have put it in danger of collapse.

statnews.com

This is real x.com/grok/status/.... Yangtze record swim times but in LLM form

Call me Dougie@bayoka.bsky.social · 9mo ago

Oops. Ooooooooooooops. I do hope that nobody has been given or denied a job/promotion based on their SpringerNature citation counts in the past 15 years. arxiv.org/pdf/2511.01675 h/t @nathlarigaldie.bsky.social

Will definitely include this example in my next talk on how to name files! ✅ Full marks for "make it easy to guess what the heck something is, based on it name".

John Gallagher@earlymodernjohn.bsky.social · 9mo ago

Genuinely delighted to download a PhD thesis from a university repository where the author has neglected to remove the words "BITCH THIS IS YOUR THESIS" from the filename.

🚀 Bioconductor 3.22 is released! Thanks to all developers and community members for contributing to the project! 🔗 Please see the full release announcement here: bioconductor.org/news/bioc_3_...

Bioconductor - Bioconductor 3.22 Released

The Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and…

bioconductor.org

We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience recruiting.paylocity.com/recruiting/j...

Lieber Institute For Brain Development - Staff Scientist I, Translational Neuroscience

A little about us:The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with develop...

recruiting.paylocity.com

This 1980s anti-drug ad, but about screen time

a close up of a young man 's face with headphones on .

ALT: a close up of a young man 's face with headphones on .

media.tenor.com

Today at #ASHG25 I will talk about the work of a talented graduate student Dev Raj Bhattarai on cell type-specific isoform expression in Alzheimer's disease at the @nanoporetech.com Education Session (12pm Rm 153). Dev will also present his work today at poster 9228T.

Today at #ASHG2025 Adam Davidovich will talk about our work on inheritance of DNA methylation patterns in mice with some interesting biology, including (to our knowledge) the first paramutation naturally occurring in mammals. Room 210C at 11am.

I’m at #ashg2025 for a few days. Reach out if you want to chat.