Just a few days until our annual hybrid TPD event! In-person registration is full, but you can still join us live on Zoom via our regular biweekly link. Register for the Zoom stream here: dfci.zoom.us/webinar/regi...
Katherine A Donovan
@katherinedonovan.bsky.social
🇳🇿 Kiwi | Scientist | Targeted Protein Degradation | Chemoproteomics | Tweets are my own
Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18
Heads up for those working in ubiquitin biology and targeted protein degradation—Lorne Ubiquitin 2025 is happening 20–23 November in Lorne, Victoria, Australia. Late abstracts are still being accepted—worth checking out if you’re looking to share your work in a focused, international setting. 🦘🦘🦘
🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: www.nature.com/articles/s41...
Unveiling the hidden interactome of CRBN molecular glues - Nature Communications
Induced proximity by molecular glues is a strategy that leverages the recruitment of proteins to facilitate their modification or degradation. Here the authors present unbiased quantitative proteomic,...
nature.com
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬 👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
🎉 2025 DFCI TPD event registration is open! 📆 Sep 11, 11:30 AM–8 PM ET, Boston 🔑 Keynote: Nathanael Gray 📝 Registration link: forms.gle/NLUSa51Btrtf... #TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
🚀 Join us for the last DFCI Targeted Protein Degradation (TPD) Seminar before our summer hiatus! 🗓 Date: July 24th We are very excited to be hosting two fantastic speakers Jonathan Bushman (AMGEN) and Guillaume Lessene (WEHI)
📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org #ubiquitin
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology! careers.dana-farber.org/job/11813/as...
Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Assistant/Associate Professor, Chemical Biology job
careers.dana-farber.org
Chembio in the Pub! The tastier, chattier version of the popular Boston conference. Jun 12th is pretty close to the GRC too so whether you're a local or visiting it would be great to hang out www.eventbrite.com/e/chembio-in... #chembio #chemicalbiology #bostonbiotech
ChemBio in the PUB 2025
Chemical Biology in the PUB
eventbrite.com
📢 Save the Date! The next FREE Dana-Farber TPD In-Person Event is coming soon! Join us for an afternoon of cutting-edge science, networking, and community building focused on Targeted Protein Degradation (TPD). Stay tuned for registration and speaker details.
Excited to be hosting next week’s DFCI TPD seminar! We’ll hear from two outstanding speakers, Rebecca Metivier and Martin Steger who will share their work on developing and applying mass spectrometry-based proteomics platforms to identify and catalog degrader targets. See you on May 15th @ 12PM EST
Happy to share that Dr. Peng Chen and Chase Suiter will be joining us to speak about their work in the TPD space on April 3rd at 12PM EST!
📣 Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 🚀🚀🚀 🌟 World-class Speakers 🌟 Cutting-edge Insights 🌟 Networking Opportunities 📅 Date: 21st March 2025 📍 Location: GSK Stevenage, UK 🔗 Register here: www.smr.org.uk/Meetings/202...
Less than 3 weeks left⏳Register by April 7 for the #Ubiquitin & Friends Symposium, May 8-9, in beautiful Vienna! Fantastic guest speakers, open slots for short talks, flash talks& posters: Great opportunity for students & #ECRs! Register soon to save your spot➡️ www.protein-degradation.org/symposium/
Very excited for our next seminar this Thursday, March 20th: Martin Schwalm (@thesgc.bsky.social, formerly Knapp lab) will share insights on UPS inhibitors and Dean Clift (TRIMTECH Tx) will discuss hijacking TRIM21 for protein #degradation! 👉Join us at 12 PM EST/ 5 pm CET (‼️ US/EU time mismatch ‼️)
More about rewiring transcription with bifunctional TCIP molecules: biological proof-of-concept in sarcoma cell lines www.biorxiv.org/content/10.1...
Excited to be sharing some of our recent work at the 2nd SMR molecular glues meeting
Society for Medicines Research@socmedres.bsky.social · 2y ago🌟Speaker Spotlight: 2nd SMR Molecular Glues Meeting🌟 We are excited to welcome Dr Katherine Donovan @katherinedonovan.bsky.social from @danafarber.bsky.social as one of our distinguished speakers! 📅 21st March 2025 📍 GSK Stevenage, UK 🔗 lnkd.in/dNwWVtwE Join us at this exceptional event!
I am excited to be hosting Prof. Jian Jin in our TPD webinar series on March 6th at 12pm! Join us to hear about his lab's strategies to target undruggable proteins
Popularity of current DIA data analysis tools (vendor-independent, based on citations of initial publication) Updated for 2024:
Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!
Nice write-up of the successful SMART TPD symposium in Shenzhen, China - co-organised with Nat Gray, Nieng Yan, Peng Chan and Shixiang Yan. So enjoyed the opportunity. #TPD #SMARTsymposia www.szbl.ac.cn/en/infomatio...
Join us for the final TPD webinar of 2024 on 12/19. @fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC" Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
Join us for the final TPD webinar of 2024 on 12/19. @fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC" Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
I really enjoyed chairing the #AACRCICR session today focused on bivalent degraders. Thank you to Michael Erb, Mikko Taipale, and Xin Zhou for the beautiful talks! #AACRchem24
Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization! onlinelibrary.wiley.com/doi/abs/10.1...
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharm....
onlinelibrary.wiley.com
‘Dark proteome’ survey reveals thousands of new human genes | Science www.science.org/content/arti...
‘Dark proteome’ survey reveals thousands of new human genes
Database confirms that overlooked segments of the genome code for a multitude of tiny proteins
science.org
Through a series of cryo-EM structures, this study shows how an E2 and ubiquitin itself can play a "structural" role to specify ubiquitin linkage. 🧪 Lovely work by Katrina Warner, @moritzhunkeler.bsky.social @kheewoongbaek.bsky.social, @katherinedonovan.bsky.social and others in the Fischer Lab!
Milka Kostic@milkakostic.bsky.social · 2y agoNew #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky. www.biorxiv.org/content/10.1...
📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange