Didn't think my chembio cup could get much fuller after the GRC Bioorganic chem last week but going to the pub event tonight too. Few tickets left www.eventbrite.com/e/chembio-in...

ChemBio in the PUB 2026

Chemical Biology in the PUB

eventbrite.com

I love lamp

Kusterlab@kusterlab.bsky.social · 12mo ago

New Preprint: High-intensity 365 nm irradiation accelerates photoreactions in living cells by up to 1000×. We show protein–drug 💊, –protein 💪, –DNA 🧬, –RNA 🧬 crosslinking within seconds, and analysis by #massspec for #proteomics, #chembio, #chromatin and #RNAbiology. www.biorxiv.org/content/10.1...

People had questions, like "Are there apples that taste & crunch like Honeycrisp? But without the existential rage about being alive?" Yep! Let's talk about them!

Sarah Taber@sarahtaber.bsky.social · 9mo ago

In honor of apple picking season: the secret of why Honeycrisp apples are so expensive! This tree is angry at being alive and will make it your problem (if you plant it)

Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...

Chembio in the Pub! The tastier, chattier version of the popular Boston conference. Jun 12th is pretty close to the GRC too so whether you're a local or visiting it would be great to hang out www.eventbrite.com/e/chembio-in... #chembio #chemicalbiology #bostonbiotech

ChemBio in the PUB 2025

Chemical Biology in the PUB

eventbrite.com

#NeilPostman #Trump #MAGA #Musk #ElonMusk #Project2025 #TheFourthReich #BadFaith #Fascism archive.is/6TBfY Still Amusing Ourselves Why does this 40-year-old book by a career academic still hit so hard? ⏬ Bluesky 'bite-sized' article thread (12 min) with added links 📖🍿🔊

The One Book That Explains Our Current Era Was Written 40 Years Ago

NYT pundits and NBA coaches alike can't stop recommending this four-decade-old book.

slate.com

Truncated gRNA sequences to target Cas9 fusions to hundreds of sites with similar sequences: www.nature.com/articles/s41... This should address a question I commonly get for GLoPro (PMID: 29735997), about targeting TF binding sites throughout the genome, rather than a single locus. Cool work.

Multi-locus CRISPRi targeting with a single truncated guide RNA - Nature Communications

A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Here the authors present a CRISPRi-based method using trun...

nature.com

Whom would you like to hear at our next event? The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale. Let us know in reply to this post, whom you would additionally like to hear!

There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications

Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...

nature.com

We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw

Thoughts for the future

Nature Chemical Biology - As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most...

rdcu.be

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk

Come with me as I troubleshoot this very high GC PCR toward clonable homology arms in an actinobacteria. Testing DMSO, Betaine 1M, and Propylene Glycol to see if we get amplification. Arms are 1000bp. Full length with arms and gene is 2800bp. Let's go! 🧵 1/n

Very neat system from Alice's team. I love the name too!

Alice Ting@aliceyting.bsky.social · 2y ago

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation! We can teach it all off 1 paper! 1. Woo 2. Hoooo!!! H/t @lianafaye.bsky.social www.biorxiv.org/content/10.1...

Molecular and genetic characterization of sex-linked orange coat color in the domestic cat

The Sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X-inactivation in female tortoiseshell and calico cats. Unlike th...

biorxiv.org

Delighted these fun explainers have made it to bluesky

Keith Hornberger@krhornberger.bsky.social · 2y ago

Skeetorial time! Let’s talk early human dose prediction. Not the fancy, need-tons-of-software and a DMPK pro kind. Just the kind that uses some basic algebra. HDP is a unifying concept for med chemists. It’s the master optimization parameter, and it can’t be easily cheated. 1/

Assume all small molecules are unselective for their protein target until proven otherwise. Even if the vendor tells you it’s a selective inhibitor for X, there’s a decent chance it isn’t selective! So how do we find quality molecules for scientific experiments? academic.oup.com/nar/advance-...

The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research

Abstract. The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection

academic.oup.com

Nice new large proteomics dataset on drug MoA applying proteome integral solubility alteration (PISA) from @dschweppe.bsky.social and Gygi lab #TeamMassSpec Article: doi.org/10.7554/eLif... Blog post by @dereklowe.bsky.social: www.science.org/content/blog...

Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

An approachable framework for the scalable implementation of proteome-wide thermal shift assays to assess drug mechanisms of action.

doi.org

Is ProteomicsDb dead? Even a single protein search just infinitely loads for me

In a wonderful intersection of my science and local policy bluesky worlds, Somerville City Councilor @benforward3.bsky.social created a better split-Gal4 system

Ben Ewen-Campen@benforward3.bsky.social · 2y ago

🪰🧬 Now that we’re off twitter, might as well re-share my recent #drosophila work here :) First up, we fixed a long-standing limitation of split-Gal4: previously, it couldn’t be controlled temporally via Gal80. Our new split-intein Gal4 fully solves this problem www.pnas.org/doi/abs/10.1...

Interesting @biorxivpreprint.bsky.social preprint by a team around Jason Thomas and Andrea Byrnes of Novartis. They developed a photoaffinity probe based on the RNA-splicing modulator branaplam for the transcriptome-wide identification of RNA binding events in native cells. doi.org/10.1101/2024...

Been a while since I checked this app and glad to see it's on the up again. Welcome new and old friends!

Thinking about how a research lab could learn from the discipline, teamwork and efficiency from a commercial kitchen as I watch Syd from The Bear think about how you could learn similar from college basketball. Minus the shouting preferably

Then we talked about on-tip processing of sorted cells. Started with @proteomicsnews.bsky.social writing about EvoSep-based method. But fortunately @schejbaljlab.bsky.social was here to talk about his on-tip method too. 5/n

ONE-TIP Preprint! Do your entire sample digestion protocol on your EvoTip!

You've probably seen talks that this was coming. Here it is! Wait. What month is it? I've been busy. Not the newest news, but still worth ta...

proteomicsnews.blogspot.com

For some reason bluesky is suggesting a ton of ornithology to me and I'm not mad at all. Significant improvement over the suggested posts on the other bird site.

🧪 Scientist? 🟦 New to BlueSky? 👀 Wanna find posts by other people in your area and use the right hashtags in your own posts? 📃 Here’s a list of around 160 science-related feeds and their hashtags. #AcademicSky #PhDSky

BlueSky Science-Related Feeds

Sheet1 Likes,Name (Click to visit feed),Tags,Contact to ask to be added to contributor list 11,<a href="https://bsky.app/profile/did:plc:ftnzzw4cnon2pzpw7i5m2xu7/feed/aaaiqnkwsgsz6">#AI&HCI</a>,#HCI,...

docs.google.com

Instead of just trying to find the people I followed on Twitter here anyone got suggestions for scientists I should be following on blue sky?

Hello world? Nice to see so many friends from "that other site" over here. Hopefully this will be a better alternative to that slow embering dumpster fire