www.nature.com/articles/s41... Read it.

How contemporary academic structures constrain scientific creativity and hold back early-career researchers - Nature Human Behaviour

In this Perspective, Haubrock et al. argue that today’s scientific structures constrain creativity and that strategic conformity is a rational response. They discuss how this holds back early-career r...

nature.com

Reading about Humboldt on holidays. Intriguingly, the river Drava is at an all-time low, which allowed for some interesting finds. A 70kg WWII bomb was dismantled, we found many bones. Some look recent (lamb?), others much older… Any guesses at what they might be??

Interested in RNA and proteins? Perfect! 😀 We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics. Find more information on our lab's homepage and get in contact via e-mail!

The calm before the storm. In the next 4 weeks, ±300 1st year medicine and ±60 1st year dentistry students will try their hand at enzyme kinetics... We are ready!

Ready to register for "GBM Compact - Focus on RNA Structure and Dynamics"? Early bird registration and abstract submission are open until June 30.

Next Wednesday, online seminar by Chris Carnie! Organised by the German Society for Biochemistry and Molecular Biology (GBM), everyone is welcome to join.

GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 3mo ago

GBM Lunch on June 3, 12:30 PM (CEST) Speaker: Chris Carnie (University Hospital Heidelberg (UKHD)) Title: "Charting determinants of cellular responses to antimetabolite chemotherapeutics" Chair: @kfeijszaja.bsky.social (University Hospital Aachen) Organizer: GBM Young Investigators #GBMLunch

I woke up to a great spotted woodpecker in our garden. This is going to be a good day 😃 For context: we live in an urban area in the Netherlands, where even sparrows are becoming rare. Our garden is a rare fleck of green in a desert of stone, with most neighbours preferring gravel gardens 🤦‍♀️🤷‍♀️

WATER SAFETY: Some people are seeing this as a paywalled article (I'm not). The original article was first published by Mario Vittone on gCaptain in 2010 and they republish it periodically. Try this one (it's also not paywalled for me but I can't tell if it is for others!) gcaptain.com/drowning/

Drowning Doesn't Look Like Drowning

Drowning is not the violent, splashing, call for help that most people expect. In this article, Mario explains what drowning really looks like and how to recognize it when its happening.

gcaptain.com

Trish Greenhalgh@trishgreenhalgh.bsky.social · 4mo ago

Every summer I repost this article on how to spot drowning. Please read it and pass on. In the last few years I’ve had SIX messages from people who saved a kid’s life after clicking on the link from my feed. slate.com/technology/2...

Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly

Sholto David@sholtodavid.bsky.social · 4mo ago

Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!

Introduce yourself with 10 acts you've seen live: Backstreet Boys (I'm a 90ies kid...) Ole Edvard Antonsen Cranberries Smashing Pumpkins Placebo Muse Green Day Foo Fighters Danny Elfman Neil Young

Marianne Alleyne@cotesia.bsky.social · 4mo ago

Introduce yourself with 10 acts you’ve seen live: Normaal Level 42 Springsteen Prince Bowie Robert Cray Grateful Dead John Lee Hooker Indigo Girls Jeff Healey (in order, pretty much - first 21 years of my life- what a weird mix)

If you are interested in PARP inhibitors and history, this might be of interest to you. www.nature.com/articles/s41.... An attempt to cover the work of thousands and their immense contributions to the development of a targeted approach to treating cancers.

Two decades of PARP inhibitor synthetic lethality in cancer - Nature

The past two decades of PARP inhibitor synthetic lethality in cancer is explored.

nature.com

We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals” www.biorxiv.org/content/10.6...

I am very excited about this seminar next week: no science this time, but a discussion on combining parenthood with a job in science. If you have specific questions --> let me know, and I'll make sure we discuss them! Not restricted to GBM members only, feel free to join!

GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 5mo ago

Next GBM Lunch on April 22 (12:30) Speaker: Lena Eckert (Netzwerk Mutterschaft und Wissenschaft) Join us for an introduction & discussion on topics of "Parenthood in Science". Chair: @kfeijszaja.bsky.social Organized by: GBM Young Investigators #GBMLunch

Some words are hard to translate. The Dutch “uitbuiken” for example. Here’s our cat demonstrating what this looks like after spending Easter with the family (lots of food involved…)

Human PARPs modify RNA nucleobases in vitro and in cells https://www.biorxiv.org/content/10.64898/2026.03.31.715305v1

I thought you should know that 😀

Admirable Women@admirablewomen.bsky.social · 5mo ago

Dr. Leila Denmark co-developed the pertussis (whooping cough) vaccine in 1932. She was the world's oldest practicing pediatrician until she retired at age 103 (practicing for 73 years). She died a supercentenarian #OTD in 2012 at the age of 114 years and 60 days. #WomenInSTEM

The next chapter in ADP-ribosylation biology: modification of uracil and guanine bases by PARP10 and PARP15 www.biorxiv.org/content/10.6...

New to Plasmidsaurus? They're offering the Addgene community their first three sequences free with code ADDGENE. https://twp.ai/4iwdRq

Not sure why, but I always have the urge to post travel updates on here... #cshlPARP, I'm on the way! Today's itinerary: Kerkrade - Aachen - Cologne - Frankfurt - NY JFK - Cold Spring Harbor!!

Are you investigating the biology of prokaryotic or eukaryotic cells? Are you looking for an excellent scientific environment to establish and lead your own research team? The I2BC is your place and a new call for team leaders is now open. More info👇Deadline 22nd April @i2bcparissaclay.bsky.social

Kathrin @katleppek.bsky.social and Ina @inahuppertz.bsky.social cordially invite all RNA enthusiasts based in the Rhineland to attend our series of inspiring in-person talks on RNA-related topics, delivered by local and invited speakers.

We’ve uploaded a bioRxiv preprint on new antibodies specific for poly-ADP-ribosylation (PARylation). These modular tools were developed and validated through novel applications of our Serine ADP-ribosylation-based technology. www.biorxiv.org/content/10.1...

Are you interested in cutting edge #Biochemistry and #ChemBio? Check out our #Biochemistry2026 meeting in Würzburg from March 16th to 18th. Deadlines for reduced early bird registration fee and abstracts have been extended to January 28th. veranstaltungen.gdch.de/microsite/in...

Did you miss the original abstract deadline? No worries, we’ve extended it to January 30th! Don’t miss your chance to be part of an exciting meeting highlighting the cutting edge of the field.

Mike Cohen@michaelnadbio.bsky.social · 8mo ago

Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...

I must admit... Websites with timers like this make me slightly nervous. We've still got 4 hours left - why the red?? 😅

Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...

The PARP Family & ADP-ribosylation

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

The YoungPI working group organised an online workshop to gain insight into the grant review process, using DFG grants as an example. The focus will be on improving our understanding from a reviewer's perspective. Our guest will be @friedemann.bsky.social Register now for the 2nd February at 4pm.

A general rather than site- & function-specific role for protein modification by ADP-ribosylation? @kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress www.embopress.org/doi/full/10....

Job alert! We are recruiting a postdoc to study a novel RNA modification: ADP-ribose. 🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...