König Lab

@koenig-lab.bsky.social

RNA Biology group at Würzburg University (@uni-wue). Previously at IMB in Mainz. We work on #RNAmodifications #splicing #decay #translation #RBP #iClip

Nucleic Acids Research is looking for a new Executive Editor! If you're an established researcher in RNA biology, translation, RNA virology, or related fields, apply! As a current Executive Editor, I highly recommend it. 📅 Deadline: 30 September 2026 academic.oup.com/nar/pages/ex...

NAR seeks a new Executive Editor

Overview of the Journal Nucleic Acids Research (NAR) is a leading open access molecular biology journal published by Oxford University Press. It provides rapid

academic.oup.com

An RNA editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to new work in #ScienceSignaling involving fruit flies and data from mice and human samples. https://scim.ag/44VKex1

A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging

The RNA editing enzyme ADAR slows intestinal stem cell aging by reducing proliferative MAPK signaling.

scim.ag

Academic tweeps! How do your institutes implement support for scientists in the rapidly changing AI-era - i.e, who is training the students to use Claude Code, and making sure they don't wreckt the cluster? Does it work well? Tell here/DM + pls RT (heading a sub-committee...)

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854636

Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...

nature.com

Sjors Scheres@sjorsscheres.bsky.social · 6mo ago

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Graphical abstract: Speckle-proximal and speckle-dependent RNA has short introns, and simultaneous emergence of multiple exons requires heightened concentration of spliceosome components.
Speckle-independent RNA has long introns and can be spliced well with or without speckles
Speckle dependent introns evolved in amniotes. The reduction in intron length was accompanied by the increase of the intronic GC content, giving rise to GC-levelled intronic architecture. This exon-intron architecture is not present outside of amniotes (Fish, Invertebrates), and these organisms lack nuclear speckles.
Tugce Aktas@aktast.bsky.social · 5mo ago

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.