Michaela Müller-McNicoll
@mixmue.bsky.social
RNAholic, Scientist, interested in architectural roles, packaging and binding codes #RNA, #splicing, #condensates
Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social www.biorxiv.org/content/10.6...
Day 2 of #LARP2026 with amazing talks, MaLaGA ice cream, and a visit to the Regensburger Dult. Thanks to all our speakers for an inspiring day of science and discussion. Special thanks to our keynote speakers @gebauerlab.bsky.social and @mixmue.bsky.social!
What happens if you delete large intronic regions? In human tissue culture cells, we found many deletions that decrease growth and some that increase it. In most cases, deletion affected expression or splicing of the gene. www.cell.com/cell-reports... 1/3
A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns
Farhangmehr et al. investigate functions of highly conserved intronic sequences in cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead to changes in p53 pathway genes. De...
cell.com
RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome By Soles et al. and Yongsheng Shi ➡️ https://genesdev.cshlp.org/content/40/13-14/1099.full UC Irvine UC Irvine School of Medicine #RNAprocessing #splicing #mRNA #transcription
How do 2 meters of DNA fit inside a nucleus you can barely see? 🧬 Our new study mapped individual nucleosomes inside human cells.
Great opportunity! We’re looking to hire a Platform Manager to lead the decelopment and operations of the @ircm.bsky.social RNA Therapeutics core facility. If you have solid expertise in #RNA biology, particularly in methodologies to synthesize and purify oligonucleotides, mRNA and LNPs, apply now!
workforcenow.adp.com
Interested in RNA and proteins? Perfect! 😀 We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics. Find more information on our lab's homepage and get in contact via e-mail!
Analytische Biochemie - Fakultät - Universität Greifswald
Universität Greifswald
biochemie.uni-greifswald.de
RNA can build. A short RNA self-assembles into a 60-subunit icosahedral cage like a viral capsid, but made entirely of RNA. The striking preprint also reveals a 57-nt RNA filament at ~2.7 Å. Congratulations, Lin Huang and colleagues! www.biorxiv.org/content/10.6...
📢 (2/2) A big thank you to all co-authors! @iskhusainov.bsky.social, @kgeissler.bsky.social @becklab.bsky.social, @embl.org, @xavierheal.bsky.social @gagneurlab.bsky.social, @savitski-lab.bsky.social, Frydman and Nedialkova lab.
Ubiquitin selective ribosome profiling reveals systematic principles of co-translational quality control
Protein biogenesis is a stress- and error-sensitive process that can lead to nascent protein misfolding and aggregation, challenging cellular proteostasis. Co-translational ubiquitination (CTU) is a c...
biorxiv.org
Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
1/3: We are proud to share that the recent work by postdocs Karen Palacio-Rodriguez and Sergio Cruz-León, from Gerhard Hummer’s department, was selected as one of the Editors’ Highlights in Nature Communications! 🎉 👏 Open-access paper: 👉 www.nature.com/articles/s41...
Nitric oxide drives proteomic diversity through alternative splicing
Nitric oxide drives proteomic diversity through alternative splicing
Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.
dlvr.it
Excited to share our new collaborative paper in @narjournal.bsky.social on the three-in-one role of SAM68 in cardiomyocyte development! Great teamwork with @Elias Bechara, @Gian Gaetano Tartaglia groups, and all collaborators
Abstract submission deadline is approaching for "The complex life of RNA" @embl.org in Heidelberg 13-16. October 2026! There will be almost 30 selected talks! Submission deadline: 7. July 2026!
EMBL Events@events.embl.org · 5mo agoJoin us for the next edition of the EMBO | EMBL Symposium 'The complex life of RNA'! 🔬🧬 The programme will include topics on transcription, RNA processing and modification, mRNA export and localisation, mRNA surveillance and decay, and more 💻 s.embl.org/ees26-12-bl
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...
Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
nature.com
How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out: www.researchsquare.com/article/rs-9...
Now it's @jpkreysing.bsky.social 's turn! 🎓🎉 Congratulations Jan Philipp on defending your PhD thesis, "Capturing Functional States in Situ with Cryo-Electron Tomography" in the @becklab.bsky.social lab! We're very excited to see more IMPRS-CBP #PhDs graduate🎓✨ #imprs_cbp #PhDlife #CryoET
What is the role of #poison-exon in regulating splicing factors in stem cells and development? Check out new work from Nathan Leclair and Mattia Brugiolo and many others in my lab @jax.org #RNA #splicing www.biorxiv.org/content/10.6...
🚨 1/5 Check out the 2nd preprint from our lab on how IRES-mediated translation of synthetic circRNAs is employed in cells and in cell-free translation extracts, a highly collaborative effort with @immagina.bsky.social & the labs of @andershlund.bsky.social and CK Chen www.biorxiv.org/content/10.6...
📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6...
How do we assess research excellence in a way that reflects today’s scientific reality? 🧪 Read the report from EMBO’s recent #policy workshop exploring this question: https://www.embo.org/wp-content/uploads/2026/04/Revisiting-the-EMBO-Funding-Criteria-A-Workshop-Report.pdf DORA CoARA
www.nature.com/articles/s41... - from @igorulitsky.bsky.social - "most chromatin regions reported as bound by trans-acting RNAs in recent studies in mammalian cells appear to be technical artifacts"
Widespread DNA off-targeting confounds RNA chromatin occupancy studies - Nature Biotechnology
Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.
nature.com
We are offering Postdoc & PhD positions 🥼 If you are interested in the intersection of X chromosome inactivation, epigenetics, aging, sex-biased disease, and allele-specific multi-omics, feel free to reach out or share this with interested candidates. More info: portal.mytum.de/jobs/wissens...
'Scientific advancement depends on freedom, openness, and truth - the very values fascism eventually destroys. Our collective response will shape the future.'
Science Magazine@science.org · 6mo agoBreaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr
New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. www.biorxiv.org/content/10.6...
And this, of course, is not scalable. And professionalizing things is expensive.
Rebecca Colesworthy@rcolesworthy.bsky.social · 6mo agoAI produces MORE editorial labor, not less. “[To weed out slop] the journal doubled its deputy editors from 6 to 11 & nearly doubled its sr editors from roughly 30 to 60. All of this is volunteer labor, unpaid academics donating time to maintain scientific quality.“ www.forbes.com/sites/johndr...
I really like this.
Keri Backus@keribackus.bsky.social · 6mo agoSuper excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics
