Very excited to announce the first MS Thesis graduation from our lab! Xiaoya Liu was one of the first to join our lab. She helped set up our lab and get our primary T cell experiments going😎. Congratulations, Xiaoya!

Such a privilege to have a job where we can play a small role in the scientific journey and development of the next generation of scientists (UC San Diego Institute of Engineering in Medicine OPALS Summer High School Internship Program) 🙏 .

Dr. @kolade-adebowale.bsky.social's team reviews macrophage mechanobiology and the potential of engineered macrophages, using genetic or non-genetic “Trojan horse” strategies, to deliver therapies and reshape the immunosuppressive TME. 👣 Follow the link: https://go.nature.com/4rKWHNP

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential - npj Biomedical Innovations

npj Biomedical Innovations - Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

go.nature.com

I’m pleased to share our lab’s first paper (a review), highlighting new insights into macrophages, their mechanobiology, and cancer therapeutic potential through both genetic and non-genetic approaches. @jacobsschool.bsky.social. www.nature.com/articles/s44...

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential - npj Biomedical Innovations

npj Biomedical Innovations - Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

nature.com

New publication alert! We use theory and experiment to demonstrate that glassy adhesion dynamics can predict anomalous migration on viscoelastic substrates. Grateful to have worked with Vivek Sharma, Ze Gong, Ovijit Chaudhuri, and Vivek B Shenoy 🙏 ! www.nature.com/articles/s41...

Glassy adhesion dynamics govern transitions between sub-diffusive and super-diffusive cancer cell migration on viscoelastic substrates - Nature Communications

This study introduces glassy adhesion dynamics within a motor–clutch framework, revealing the mechanism by which cellular and extracellular timescales interplay and govern anomalous cancer cell migrat...

nature.com

Excited to have delivered a guest lecture to students in our "Introduction to Bioengineering" course about some of the exciting and cutting-edge research in studying cancer-immune interactions. Thx, Prof. Reem Khojah, for the invitation (and action shots!) @ucsandiego.bsky.social.

We had our inaugural "4th floor Friendsgiving". Many thanks to Drs. Vira Kravets and Erika Cyphert for helping organize. Gotta love the Snoopy with a scarf background pic. Looking forward to growing our community of Bioengineers on the 4th floor (UC San Diego Bioengineering). 😎

Thank you, Prebys Foundation, for supporting our work to understand how physical cues regulate macrophage and T cell responses in diseases like cancer. These insights can help us maximize the clinical impact of macrophage- or T cell-targeting therapies. today.ucsd.edu/story/1-mill...

$1 Million from Prebys Foundation Supports Pivot Grants to Drive Medical Research at UC San Diego

The UC San Diego School of Medicine announced the inaugural recipients of its pivot grant program, an initiative made possible by a $1 million gift from Prebys Foundation to help protect San Diego’s b...

today.ucsd.edu

First Kolade Lab social outing (mini-golf ⛳️then dinner). Starting a lab is tough, but this amazing and fearless crew has made it so much easier over the past four months!

New paper! We find that fast matrix stress relaxation potentiates human monocyte 3D migration by generating protrusive forces and is dependent on the Cdc42-WASp axis. Thanks to our amazing collaborators👏! #viscoelasticity #mechanobiology @stanford-chemh.bsky.social www.pnas.org/doi/10.1073/...

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices | PNAS

Circulating monocytes are recruited to the tumor microenvironment, where they can differentiate into macrophages that mediate tumor progression. To...

pnas.org

Recent review from The Morgan Huse Laboratory @ Memorial Sloan Kettering Cancer Center on "Mechanoregulation of lymphocyte cytotoxicity". www.nature.com/articles/s41...

Mechanoregulation of lymphocyte cytotoxicity - Nature Reviews Immunology

Cytotoxic T lymphocytes and natural killer cells destroy target cells using a mechanically active cytolytic immune synapse. This Review examines the various ways in which mechanical forces contribute ...

nature.com

Our confocal got installed today! Gotta celebrate the wins. #BabyPI

Great catching up with our seminar speaker, Professor Darrell Irvine, and our colleagues from @UCSD's Jacobs School of Engineering.

We had a great time celebrating our one-month anniversary at UC San Diego Bioengineering with Dr. Vira Kravets's and Dr. Xiaohua Huang's labs, and Isgard Hueck. Special thanks to Dr. Vira Kravets lab for the amazing lab swag including a gift of a very studious cytotoxic T cell mascot (to be named!)

Our lab doors opened on Monday @ucsdbe and we had lab lunch today! Very excited to have three grad students (Sophia, Ruturaj, and Xiaoya) and one undergrad (Josie) rotating. More of our scientific adventures to come😎!

Great catching up with my friend Prof. Toshiro Hara from the University of Michigan Medicine and meeting Prof. Gerald Pao from the Okinawa Institute of Science and Technology (OIST) in San Diego.

In Memory of Andy Acrivos: University of Minnesota Alumnus and Titan of Chemical Engineering cse.umn.edu/cems/news/me...

In Memory of Andy Acrivos: CEMS Alum and Titan of Chemical Engineering

Andreas (Andy) Acrivos passed away on February 17, 2025. Born in Greece in 1928, Prof. Acrivos arrived at Minnesota in 1950 following undergraduate studies at Syracuse University, becoming the  second...

cse.umn.edu

@ucsandiego.bsky.social newest faculty member @kolade-adebowale.bsky.social sharing the culmination of his work and the vision of his lab #Afrobiotech

Explore this Starter Pack 🚀 with researchers, engineers, and enthusiasts passionate about #Biopolymers & #Biomaterials in nanoscience, sustainable materials, 3D bioprinting, regenerative medicine, and related fields. 🔗 DM/comment/tag to self-nominate or suggest others! go.bsky.app/HCEddD2

"Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise… nearly equal amounts of these structures and their ‘right-handed’, mirror-image forms."

Asteroid fragments upend theory of how life on Earth bloomed

Samples from Bennu contain the chemical building blocks of life — but with a twist.

nature.com

Excited for the 2025 GRS/C Physical Science of Cancer kick-off in Pomona, CA soon with all the exciting science. Thanks to GRC Co-Chairs Kandice Tanner, Erik Sahai, and my GRS Co-Chair Gabrielle Grifno. Please tag your favorite moments with #POC_GRC_2025! Safe travels everyone.

Because you have nothing else to worry about, remember that, starting May 25, you will have to use SciENcv to generate your biosketch for any NIH application. LINK here: www.ncbi.nlm.nih.gov/sciencv/

Applications are still being accepted for the Summer 2025 REU, UCSD-BRIDGE @ UC San Diego! The deadline is February 11. More details below 👇.

ATP acts as i) cellular energy currency, ii) danger signal, & much more ATP induces fast migration of leukocytes, w depends on P2X7, Panx1 channels, & CaMKII, w leads to actin cytoskeleton (cyan) changes www.science.org/doi/full/10.... @focalplane.bsky.social #CellMigration #fluorescencefriday 🧪🔬

We've a postdoc opening for our lab at the Broad: Cambridge MA! Must have experience in toxicology + data science Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models! broad.io/mlcbpostdoc

It's time 🙃!! The soon-to-be-open Bomba-Warczak Lab at UPenn is HIRING postdocs! If you're interested in mitochondria, proteomics, neurons and/or oocytes, and want to join a young & vibrant lab in a vibrant city - apply 👉 www.bombawarczaklab.com/people/now-h... #TeamMassSpec #mitochondria

Happy to share our Current Opinion by @mattjwalker.bsky.social and @delphe.bsky.social🧪 We review how advances in dynamic #hydrogel based #mechanobiology platforms are critical to understand disease progression in cancer and fibrosis @elsevierconnect.bsky.social www.sciencedirect.com/science/arti...

My latest Research Highlight is now online @natrevmcb.bsky.social! The Brangwynne lab uncovers how chromatin heterogeneity influences condensate formation during #CellMigration, revealing intriguing insights into nuclear mechanics. 🔗 go.nature.com/3ZpwGH7 OG Paper: go.nature.com/3Baxpnn

Chromatin compaction during confined cell migration induces and reshapes nuclear condensates - Nature Communications

Cell migration through narrow constrictions during cancer metastasis significantly deforms the nucleus, creating mechanical stress on chromatin. Here, the authors reveal that such chromatin deformatio...

go.nature.com

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Altmetric@altmetric.com · 2y ago

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.

Many tx studies (Mujal... Azizi…)failed to validate M1/M2 signatures in vivo. Many also suspected that calling cells bearing ‘prototypical M2’ genes ‘‘immunosuppressive’ was simplistic + incorrect. Nonetheless many (us too!) leaned on the simplification. Arja addresses the reality head on…thnx JEM

Waggoner Lab@labwaggoner.bsky.social · 2y ago

Rather than immune suppression, CD206+ TAMs recruit a tumor-reactive network of CD8 T cells, cDC1s, and NK cells doi.org/10.1084/jem.... @maxkrummel.bsky.social @jexpmed.bsky.social