Kufer Lab , Department of Immunology
@kufer-lab.bsky.social
Department of Immunology Institute of Nutritional Medicine #unihohenheim #immunosky https://immu.uni-hohenheim.de/en
Timo-Daniel Voss @unihohenheim.bsky.social and co-authors show that C-terminal lysine residues localise NLRP10 at lipid droplets and govern #NLRP10 oligomer formation. link.springer.com/article/10.1... Press releases: www.uni-hohenheim.de/index.php?id... idw-online.de/de/news873496
Our friends at Sheerbroke University identified how NLRC5 helps the immune system to combat cancer. Congratulations to Subburaj Ilangumaran and his team! Check out their new publication academic.oup.com/immunotherap...
NLRC5 expression within tumor cells is critical to activate adaptive and innate antitumor immune responses
AbstractIntroduction. Tumors downregulate NLRC5 expression to reduce MHC-I and evade CD8+ T cell–mediated killing. Introducing full-length NLRC5 (N5FL) or
academic.oup.com
NLRP10 is activated at lipid droplets. Check out our new paper just published at EMBOReports! link.springer.com/article/10.1...
C-terminal lysine residues localise NLRP10 at lipid droplets and govern NLRP10 oligomer formation - EMBO Reports
NLRP10 is an atypical member of the NLR family because it lacks a leucine-rich repeat domain at its C-terminus. Here, we show that in human epithelial cells and keratinocytes NLRP10 oligomerises in re...
link.springer.com
#WeekendRead! #MomIsAlwaysMom! Fan Zheng Chen &co show @science.org that a maternal diet-derived fatty acid contained in breast milk potentiates Th1 responses in newborns protecting against bacteria & viruses throughout adulthood! doi.org/10.1126/scie...
Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting
How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the ...
doi.org
Zur Wichtigkeit der Freiheit von Wissenschaft. Live in Hohenheim
Universität Hohenheim@unihohenheim.bsky.social · 3mo agoGrundsatzrede von MP Winfried Kretschmann: ➡️ „Die Wissenschaft ist zentral für das Funktionieren einer freien Gesellschaft.“ ➡️ „Um in den Debatten verstanden zu werden, muss Wissenschaft verständlich sein – auch über den akademischen Raum hinaus.“ @regierungbw.bsky.social @mwk-bw.bsky.social
Just arrived in Paris. Looking forward for an exzellent meeting.
The Shigella Meeting@shigellameeting.bsky.social · 11mo agoCome and join us in Paris 2026 to talk all about Shigella!
Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage Petr Broz @brozlab.bsky.social and colleagues www.embopress.org/doi/full/10....
Our new manuscript describing the function of the basic c-terminal domain of NLRP10 is now available at Biorxiv. www.biorxiv.org/content/10.1...
C-terminal lysine residues localise NLRP10 at lipid compartments and govern NLRP10 oligomer formation
NLRP10 is an atypical member of the NOD-like receptor (NLR) family because it lacks a leucine-rich repeat domain at its C-terminus. Recently, NLRP10 has been shown to form an inflammasome, however, th...
biorxiv.org
Very nice review article on NLRP3 from Alex Weber et al. online! The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets doi.org/10.1038/s415...
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets - Nature Immunology
Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies.
doi.org
We are proud to present first data on our CAPE study at the #IUIS2025 in Vienna this week. Come and discuss with us at Lucy’s poster “Postprandial dynamic of immune cell responses and serum concentration of PRR ligands in humans” Thursday, 21 August 2025, 12:15 - 13:45 Poster III.366
Warm invitation to the DGfI Autumn School! 💡 Deadline for application: July 31, 2025 The DGfI Autumn School invites you to embark on an up-to-date educational journey through the immune system. dgfi.org/akademie-fue... Registration: dgfi.org/akademie-fue... Program: dgfi.org/wp-content/u...
Lucy's first paper on our RESIST PP project, describing a sensitive bioassay to measure NOD1/2 ligands in serum and differential postprandial NOD2 activation has been published! Congratulations! doi.org/10.3389/fnut...
Weltweit breitet sich eine neue Coronavariante aus. Der Infektiologe Leif Erik Sander sagt, was inzwischen über die Risiken einer Covid-Erkrankung bekannt ist und wer sich noch mal impfen lassen sollte.
Corona: Neue Variante NB.1.8.1, Impfung, Long Covid - Experte von der Charité klärt auf
Weltweit breitet sich eine neue Coronavariante aus. Der Infektiologe Leif Erik Sander sagt, was inzwischen über die Risiken einer Covid-Erkrankung bekannt ist und wer sich noch mal impfen lassen sollte.
spiegel.de
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization. Out @natgenet.nature.com: rdcu.be/eqGgf
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
Timo Voss from our group will present news on NLP10 at the #NCII in Tübingen. Have a look at poster # P041 innate-immunity-conference.de
NCII: Novel concepts in innate immunity
innate-immunity-conference.de
Next week the Novel Concepts in Innate Immunity Syposium in Tübingen starts! Great line of Speakers put together by Alex Weber. innate-immunity-conference.de
NCII: Novel concepts in innate immunity
innate-immunity-conference.de
🗣️Our EMBO Lecture Course "Cell-autonomous defense and innate immunity" now is open for registration. We are proud to present an excellent line of speakers! Join us in India! 👇 meetings.embo.org/event/25-imm...
Cell-autonomous defense and innate immunity
Cell-autonomous defense encompasses the inherent mechanisms of the cell that allow individual cells to protect themselves from infectious and inflammatory dangers. Recent advancements in the field in…
meetings.embo.org
Great Promethion-powered research from Anja Bosy-Westphal & colleagues @ Kiel University – “short-term consumption of protein-enriched UPFs did not prevent overeating but did favourably affect energy partitioning”! 🧪 www.nature.com/articles/s42...
Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance - Nature Metabolism
This single-blind crossover trial shows that the short-term consumption of protein-enriched ultra-processed foods does not prevent overeating but favourably affects energy partitioning.
nature.com
Annual Meeting of our RESIST-PP consortium. Having an intense and interesting meeting in Murcia, Spain. Thanks to Pablo Pelegrin for perfect organization.
Rho GTPases emerge as more general regulators if NLR proteins. See news on Rac2 and Nlrp3.
Journal of Experimental Medicine@jem.org · last yr.The Boyer group @lauboye.bsky.social show NLRP3 #inflammasome activation in circulating myeloid cells by human RAC2 gain-of-function variants that are linked to rare immune disorders. rupress.org/jem/article/... 📘 In Genes & Immunity collection: rupress.org/jem/collecti... #HKS2025
Prof. Wagner and Team are developing nice games to teach immunology. lnkd.in/e5AKif6w Check it out: 😀👍 lnkd.in/eHPRakb7 #immunosky
This link will take you to a page that’s not on LinkedIn
lnkd.in
With this #rothenfels2025 has come to an end🏁 Thanks to everyone who came and contributed with talks and discussions and fun and made it this special type of meeting🤩😎 Hope to CU again next year for #rothenfels2026 on March 16 to 18 - mark your calendars!📅 @dgfi-yi.bsky.social @dgfi-org.bsky.social
Dixon et al. identified ABHD17 enzymes as negative regulators of NOD2 that affect its membrane localization. 🔬 See my comment for details👇 doi.org/10.1016/j.jc...
Redirecting
doi.org
🥳 We achieved our first Milestone with HDHL #Food4Health! The main objective is to align R&I priorities among funding programmes by identifying research and policy needs to overcome the siloed approach between health & nutrition. Interested in the specific objectives of this project? bit.ly/3QOqX9Q
Santosh Chauhan and friends put together a great line of speakers for the EMBO Conference "Cell-autonomous defense and innate immunity"🎤 3–5 December 2025 | IN-Hyderabad More news coming soon... Stay tuned! 👇👇 coming-soon.embo.org/ielc25-02
Cell-autonomous Defense and innate immunity
coming-soon.embo.org
What the sh*t did I eat? "Metagenomic estimation of dietary intake from human stool" Interesting news. Can we finally really say what I person eat? www.nature.com/articles/s42...
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
nature.com
And keynote speaker of day 2 Karsten Hiller of @tubraunschweig.bsky.social is giving us a deep dive into immuno metabolism in macrophages: #itaconate rules ✌🏻🤓 #Rothenfels2025
Timo Voss from our group presented news on NLRP10 at the Burg Rothenfels Meeting. Very nice and interactive event! #DGfI
