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Sze Chai Kwok

@kwokszechai.bsky.social

Cognitive neuroscientist studying memory (lab: http://www.kwoklab.org/), associate prof. Duke Kunshan University. twitter: https://twitter.com/Kwokszechai

18 Posts216 Follower383 Folgt
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Sze Chai Kwok@kwokszechai.bsky.social · 5mo ago

also elucidating putative mechanisms underlying fmri findings eg. doi.org/10.1002/hbm....

Immediate memory for “when, where and what”: Short‐delay retrieval using dynamic naturalistic material

We investigated the neural correlates supporting three kinds of memory judgments after very short delays using naturalistic material. In two functional magnetic resonance imaging (fMRI) experiments, ....

doi.org

Christian Schnell@neuroschnell.bsky.social · 5mo ago

How does the medial posterior parietal cortex contribute to temporal order memory? This study shows that population activity in macaque mPPC encodes evolving temporal context during encoding and synchronized retrieval dynamics that predict order judgments. journals.plos.org/plosbiology/...

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Sze Chai Kwok@kwokszechai.bsky.social · 5mo ago

Providing neuronal insight into how we judge temporal order of episodic moments ~ and linking encoding and retrieval.

PLOS Biology@plosbiology.org · 5mo ago

Temporal order memory involves hippocampus & prefrontal cortex, but what about mPPC? @kwokszechai.bsky.social &co show that population activity in mPPC reflects evolving temporal context during encoding & synchronized retrieval dynamics that predict order judgments @plosbiology.org 🧪 plos.io/4dZmdef

Paradigm and recording sites. Top: Temporal order judgment (TOJ) task. In each trial, the monkey watched an 8-s naturalistic video, and following either a 0-s (immediate) or 3.6-s (delayed) retention interval, judged which of two probe frames had appeared earlier in the video to obtain a reward. All still frames displayed in Fig 1A were generated and assembled by the authors for illustrative purposes of the task design and do not contain any third-party copyrighted material. Bottom left: Upper panel: Anatomical MRI images of monkey Mercury showing the position of the recording chamber (blue) implanted in the medial posterior parietal cortex (mPPC). Bottom panel: CT images aligned with T1-weighted MRI images visualizing electrode locations in monkeys Mercury and Jupiter. The images were generated by the authors using 3D Slicer software, and no third-party copyrighted material is included. Bottom right: CT image aligned with T1-weighted MRI showing electrode locations in monkey Mars (Experiment 2). The images were generated by the authors using 3D Slicer software, and no third-party copyrighted material is included.
john sakon@johnsakon.bsky.social · 10mo ago

For those coming to SfN, I’ll be giving a talk showing evidence of hippocampal neuronal replay 🎞️🔁 in HUMANS as part of the “Representation of Time in the Brain” minisymposium (Wednesday morning) Our stellar group of speakers also wrote a preview of the session in @sfnjournals.bsky.social #sfn2025 🧠

Neural Representation of Episodic Time

Inspired by recent discoveries of neural populations that track time for specific moments (time cells) and elapsed durations (temporal context and periodic time cells), this review, based on a minisym...

jneurosci.org

Qihong (Q) Lu@qlu.bsky.social · last yr.

Key-value memory network can learn to represent event memories by their causal relations to support event cognition! Congrats to @hayoungsong.bsky.social on this exciting paper! So fun to be involved!

Hayoung Song@hayoungsong.bsky.social · last yr.

How does the brain🧠 make causal inferences and use memories to understand narratives🎬? We built an RNN🤖 with key-value episodic memory that learns causal relationships between events and retrieves memories like humans do! Preprint www.biorxiv.org/content/10.1... w/ @qlu.bsky.social, Tan Nguyen &👇

Edvard I Moser@edvardmoser.bsky.social · last yr.

Your brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...

Event structure sculpts neural population dynamics in the lateral entorhinal cortex

Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

science.org

Mayank Mehta@mayankmehta.bsky.social · last yr.

🧠🧠Announcing: Neural computations without borders 🧠🧠 So many students and postdocs are stuck due to visa, or other hurdles. To help in a small way, I will mentor about ten students/postdocs in neural computation, or neuro-AI projects, leading to publication/s.

Paul Frankland@franklandlab.bsky.social · last yr.

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

Systems consolidation reorganizes hippocampal engram circuitry

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

rdcu.be

CLaE@claeneuro.bsky.social · last yr.

Nature Neuroscience Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks www.nature.com/articles/s41...

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks - Nature Neuroscience

The temporal order of events in working memory is thought to be reflected by ordered neuronal firing at different phases. Here the authors show that this is not the case and that phase order is linked...

nature.com

Blake Richards@tyrellturing.bsky.social · 2y ago

Two cool papers out in Neuron today on memory. 1. Animals can be trained to activate specific remote memories at will: www.cell.com/neuron/fullt... 2. Interactions between cortex and amygdala during reactivation in NREM sleep help enhance perceptual memories: www.cell.com/neuron/fullt... 🧠📈 🧪

Closed-loop modulation of remote hippocampal representations with neurofeedback

Animal models of memory retrieval trigger retrieval with cues and measure retrieval using behavior. Coulter et al. developed a neurofeedback paradigm that rewards hippocampal activity patterns associa...

cell.com

Kobe Desender@kobedesender.bsky.social · 2y ago

Why does it feel good to be sure? In new work @voalan.bsky.social @andero.bsky.social and I bridge confidence and affect. In perceptual DM, we found a remarkably consistent association between both measures! ↓↓↓ link: www.tandfonline.com/doi/full/10.... #PsychSciSky #Neuroscience #Neuroskyence

Metacognitive confidence and affect – two sides of the same coin?

Decision confidence is a prototypical metacognitive representation that is thought to approximate the probability that a decision is correct. The perception of being correct has also been associate...

tandfonline.com

@liladavachi.bsky.social · 2y ago

🎈New paper🎈 Led by the inimitable @asieh.bsky.social Hippocampal dysfunction in medication naive patients with schizophrenia during a memory task resolves with drug treatment. Incredible team effort! urldefense.proofpoint.com/v2/url?u=htt...

Impaired hippocampal circuitry and memory dysfunction in schizophrenia

Nature Mental Health - Dysfunction in the hippocampal circuitry in individuals with first-episode schizophrenia and delusions is linked to deficits in behavioral pattern separation and recognition...

urldefense.proofpoint.com