The field of mathematics is being devastated in front of our eyes. For neuroscience, experimentalists may be safe, but how long until the AI-research wave takes over our computational/theoretical neuroscience? Is there any reason they can't? They can code, they can do maths. They know neurobiology

Zach Weinersmith@zachweinersmith.bsky.social · 6d ago

OpenAI just blooped hundreds of proofs and counterexamples to open problems: github.com/openai/math/... Boggling.

Mix. selectivity is everywhere in cortex: from vis. to PFC This paper relates to Cover's theorem but the typical explainer kind of sucks I'll try to explain how the theory relates to the paper, and the importance of "weird" neurons A🧵with my toy model and notes: #neuroskyence #compneuro #NeuroAI

How do you 'learn' intuition? Or worse, how do you 'teach' intuition?

Samuel Eckmann@samueleckmann.bsky.social · last mo.

"The first rule of the Intuition Club is: you don’t talk about the Intuition Club. The second rule is, if you really want to talk about intuition, make it sound casual and accessory, because we ain’t the psychology department."

"The first rule of the Intuition Club is: you don’t talk about the Intuition Club. The second rule is, if you really want to talk about intuition, make it sound casual and accessory, because we ain’t the psychology department."

Natalie Christie Peluso 🧠@nataliepeluso.com · 4mo ago

While this essay is centred on mathematics, the gist is the same for any human conceptual thought facing AI Intelligence is process, path-walking, culture, collective, accretive #neuroskyence davidbessis.substack.com/p/the-fall-o...

This is wild! cims.nyu.edu/~tristanb/st...

SE Gyges@segyges.bsky.social · last mo.

to tldr the drama for humans if nobody has: someone, who is a good mathematician working with other mathematicians and using LLMs, appears to have mostly solved Navier-Stokes. he then got forced to go public early because openai thought they could scoop him and threaten his career he has tenure.

to tldr the drama for humans if nobody has: someone, who is a good mathematician working with other mathematicians and using LLMs, appears to have mostly solved Navier-Stokes. he then got forced to go public early because openai thought they could scoop him and threaten his career he has tenure.

How the cerebellum separates related contexts—now out in Nature! Martha Garcia-Garcia led this tour de force, with theory from @somnirons.bsky.social & Michał Wójcik. Martha is on the faculty market, and I could not recommend her more highly. My lab is also recruiting! www.nature.com/articles/s41...

Excited to share the lab’s first publication, co-led by talented postdoc Chuyi Su @chuyisu.bsky.social We leveraged cell type-specific optogenetics in the macaque cerebral cortex to elucidate the role of excitatory and inhibitory neurons in visual form processing. www.nature.com/articles/s41...

🎉 New paper (and data) on editorial & peer review at Science and Science Advances, two elite general science journals. With a wonderful team! @samzhang.bsky.social, @nicklaberge.bsky.social, Quinten and @aaronclauset.bsky.social. 1/ www.science.org/doi/full/10....

This is wild. >1/2 of HC synapses disappear in artificial hibernation, come back in same/similar locations & memories intact. ~1/2 of engram synapses-between two memory-tagged cells-are clustered on dendrites, those preferentially spared. Not biggest synapses. 1/ www.science.org/doi/10.1126/...

The apical dendrite looks great, and does wonders in a slice. What does it do in the living cortex? It depends on the cell. A causal spatial role for apical dendrites in the cortex www.biorxiv.org/content/10.6... by @anyiliu.bsky.social with @kenneth-harris.bsky.social and @fedrossi.bsky.social

Parallel independent #voltage #computing along #dendrites of #CA3 pyramidal #neurons | Science www.science.org/doi/10.1126/...

Parallel independent voltage computing along dendrites of CA3 pyramidal neurons

Dendritic computation contributes to information processing in cortical circuits. Hippocampal CA3 plays a central role in navigation, but how the dendrites of CA3 pyramidal neurons process information...

science.org

Alpha rhythm determines speech perception rate? And speeding it up makes unintelligibly fast speech comprehensible? This is nuts! www.pnas.org/doi/abs/10.1...

Ethological learning (hunting prey) during the critical period resets synaptic setpoints in mouse binocular visual cortex www.cell.com/neuron/fullt... - really interesting paper from @turrigiano.bsky.social and colleagues!

Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex

Bissen et al. show that prey capture learning profoundly reshapes visual cortical circuitry and function during developmental critical periods, but not in adulthood. These learning-induced structural ...

cell.com

We have a new preprint! By studying neuronal heterogeneity in CA3, we found a weird but powerful new feature in the hippocampal circuitry! 🧠 #neuroskyence 🧵.. Morse-Mora et al. | Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans doi.org/10.64898/202...

Happy to share our latest work, out today! We show that spatial representations and their dynamics differ across anatomical compartments of hippocampal CA3, and that these differences can be explained by the level of recurrent connectivity in each compartment www.sciencedirect.com/science/arti...

Recurrent connectivity shapes spatial coding in hippocampal CA3 subregions

Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments, yet how they emerge from the u…

sciencedirect.com

Our work on goal-directed theta sweeps is out! We found two different types of theta sweeps in the rat hippocampus. During random foraging, left-right alternating sweeps dominated (Vollan, 25). However, during memory-guided navigation sweeps pointing to hidden goal locations emerged with learning.

New paper from Ulanovsky's group: With brain recordings from🦇 flying in a 200m tunnel, the group discovered that place cells of CA1 exhibit dense spatial coding, i.e., multiple place fields, and cells of CA3 exhibit ultrasparse coding, i.e., one place field. www.nature.com/articles/s41...

Sparse-to-dense coding transformation between hippocampal areas CA3 and CA1 - Nature

The hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.

nature.com

10. As AI improves, it will automate more of what we used to do manually. We may see two publication ecosystems: one written by Agents for Agents, and one written for humans. Humans’ role may shift to choosing the questions, judging the evidence, and deciding what matters.

I love this work, check out Lucas' talk on the study as part of the superlab journal club... youtu.be/hCuUE7XEg8o?...

Lucas Tian (Rockefellar)

YouTube video by Andrew Pruszynski

youtu.be

Nature@nature.com · 5mo ago

Nature research paper: Neural representation of action symbols in primate frontal cortex go.nature.com/4v1FDED

I don't think our culture is ready for accepting this idea, and probably some percentage of humans never will be. My guess: hundreds of years from now a majority will agree with this, but many still won't, and it will correlate with religion and education. (See, e.g., Darwinian evolution) 🧠📈 🧪

Earl K. Miller@earlkmiller.bsky.social · 5mo ago

There Is No Hard Problem of Consciousness www.noemamag.com/there-is-no-... #neuroscience

Seems like seaborn really hates jet colormap!

Now out in Nature Machine Intelligence @NatMachIntell “Adopting a human developmental visual diet yields robust and shape-based AI vision”: doi.org/10.1038/s422.... A wonderful case where brain inspiration improved AI. With @martisamuser.bsky.social, Radek Cichy and @timkietzmann.bsky.social .

1/10 When the going gets tough, the dendrites get going. Here is a summary on our new paper just published in @science.org on flexible learning in frontal motor cortex. With @mattlark.bsky.social 🔬. #neuroskyence #neuroscience 🔗 doi.org/10.1126/scie...

Tuft dendrites in frontal motor cortex enable flexible learning

Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for ac...

doi.org

Now in PRE: "Transient dynamics of associative memory models." I argue that the "blackout catastrophe" is not catastrophic when viewed from an out-of-equilibrium, dynamical perspective. Journal: journals.aps.org/pre/abstract/10.1103/42y2-bsh1 PDF: dclark.io/media/clark-...

Nicely contrary to how I'd thought this worked: disrupting theta-timescale spiking impairs learning but leaves hippocampal replay intact. Suggests replay doesn't need clean theta sequences during behaviour to form. https://doi.org/10.1101/2025.09.15.675587

This is so, so well-articulated.

Minas Karamanis@minaskar.bsky.social · 7mo ago

Hey, I wrote a thing about AI in astrophysics ergosphere.blog/posts/the-ma...

This paper looks interesting, I look forward to reading it: www.cell.com/neuron/fullt... But, my guess is that there's an interpretation based on *prediction*, rather than "context modulation", that would be more theoretically relevant. #neuroscience 🧪

Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing

Combining intracellular and extracellular recordings, calcium imaging, and holographic circuit mapping, Hendricks et al. identify a feature-specific pyramidal cell-to-somatostatin interneuron microcir...

cell.com

The impact of bioRxiv in numbers @richardsever.bsky.social

I am looking for a theory/computational POSTDOC position in EU or east coast US. I am interested in how learning and plasticity shape population dynamics & representational geometries & how these changes are reflected in behavior. If you are at #COSYNE2026 & interested, hit me up in Whova, not here