College lab class ends with 32 people on antibiotics for deadly germ exposure arstechnica.com/health/2026/...

College lab class ends with 32 people on antibiotics for deadly germ exposure

Lab students were supposed to ID a mild germ. They all identified a deadly pathogen.

arstechnica.com

I am very excited to share the work of my PhD with @eddaschulz.bsky.social, now on BioRxiv! 🎉 🧵⬇️ (1/9) How does the transcription↔️chromatin crosstalk ensure monoallelic expression?

bioRxivpreprint@biorxivpreprint.bsky.social · last wk.

Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome https://www.biorxiv.org/content/10.64898/2026.07.22.737064v1

Thank you @natgenet.nature.com for this nice Research Briefing www.nature.com/articles/s41... on our recent paper reporting live-cell measurements of Sox2 promoter bursting kinetics when varying its genomic distance from the SCR enhancer 👉 www.nature.com/articles/s41...

The genomic position of an enhancer modulates bursting dynamics of the cognate promoter - Nature Genetics

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

nature.com

Microscopy Nodes 3.1 is out for Blender 5.2! 🎉 This has cool new features for conditional masking, working with even larger data (regional upscaling), and data manipulation! Watch the new youtube tutorials that explain the features: www.youtube.com/playlist?lis...

🚀🔬 Can cell shape, signal and movement tell us about a cell's future? #DeepLearning studies now predict cell fate from #microscopy. Together w Rita, @mariodelr.bsky.social, @inesmcunha.bsky.social, @juliettegriffie.bsky.social + @guijacquemet.bsky.social👇 www.preprints.org/manuscript/202607.1414/v1

A post about how to make microscopy images as accessible as possible. quantixed.org/2026/07/21/c...

I wish I did not have to bring up this old tweet from ‘that other place’ every now and again but here we are (again) and here it is…

New favorite way to color code microscopy data: this is a real 3D confocal image of an unidentified larvae stained for actin (muscles fibers here). Looks like a watercolor painting! #microscopy #ImageJ #FluorescenceFriday #microscopyMonday

Segmenting individual cells in microscopy is much easier these days thanks to foundation models. Can we use these models for other tasks, such as cell classification? We investigate in our latest work, finding big improvements for object and pixel classification compared to classical approaches.

Excited to share the first preprint from my lab! Transcription has been implicated in regulating SMC complex function, but how this works has been unclear. Here, we use a yeast quiescence model to examine how transcription targets condensin.

bioRxivpreprint@biorxivpreprint.bsky.social · 3w ago

Asymmetric condensin loop extrusion is regulated by RPA-coated single-stranded DNA in quiescent cells https://www.biorxiv.org/content/10.64898/2026.07.10.737861v1

@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...

Nature Protocols@natprot.nature.com · 3w ago

New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)

Sharing a big update: I started a group at the MPINAT in Göttingen! We will develop AI for analyzing how proteins interact in the cellular environment based on cutting edge imaging. This appointment is in parallel to the university, where I will retain my current group.

MPI for Multidisciplinary Sciences@mpi-nat.bsky.social · 4w ago

AI meets cutting-edge microscopy: Welcome Constantin Pape, head of our new Machine Intelligence in the Life Sciences group! 👋 🔬 His team develops AI methods to analyze high-resolution microscopy & cryo-EM data to better understand the function of proteins and protein complexes inside cells. (1/3)

Fully packed room with literally hundreds of people for our FENS symposium on 3D genome regulation in the brain. This was an amazing lineup of speakers, too, a star after star, and then the dinner was something else 👌 Feeling so privilaged! ❤️ #FENS2026 w @apombo1.bsky.social @boyanbonev.bsky.social

It's day 3 of the United States of Science 2026. 28 states are closed out. Most of the big states still on the board. 31 bubbles for Pennsylvania 41 for California 46 for Ohio 86 for Texas 109 for NY 123 for Florida Who's going to help get them finished? Fill a bubble here givebutter.com/USS2026

Are tapes a good option for long-term cold storage of microscopy data? I'm looking at storing ~200 TB with no recurring fee (no cloud) and with as little esoteric server/command line fuss as possible www.ibm.com/fr-fr/produc...

Excited to see James' Genome-wide Absolute Quantification of Looping paper out in @natsmb.nature.com : www.nature.com/articles/s41... This has been in collaboration with @lucagiorgetti.bsky.social @leonidmirny.bsky.social @zechnerlab.bsky.social labs. Brief thread below on some key updates

Anders Sejr Hansen@andersshansen.bsky.social · 2y ago

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

Yes. I contacted them by email and they are working to fix it with their developer.

Manny Ares 👀@mannyares.bsky.social · last mo.

Anyone else getting blocked from bioRxiv just for clicking on a BlueSky link?

Truly bizarre story of how two papers from the 1940s by physics pioneer Max Planck have been "retracted" from Naturwissenschaften, potentially by an algorithm, for anachronistic "plagiarism" issues, leaving the current editor baffled (but it is Springer Nature so.... www.science.org/content/arti...

Why have papers by one of history’s most famous physicists been retracted?

Springer Nature has removed two studies by Max Planck. A bot may be to blame

science.org

New paper from the Birol lab @mdc-berlin.bsky.social that I’m happy to have contributed image analysis to: “Spreading α-synuclein rewires organelle communication and impairs neuron–astrocyte mitochondrial quality control” doi.org/10.64898/2026.06.19.733342 🧪🔬

Spreading α-synuclein rewires organelle communication and impairs neuron–astrocyte mitochondrial quality control

Progressive intercellular spreading of α-synuclein (αS) is implicated in pathology initiation and propagation of synucleinopathies. However, how recipient neurons respond to incoming αS and whether these responses contribute to disease-associated early metabolic events, remains unknown. Here, using extracellular monomeric αS to model the earliest cellular response to spreading, we found that internalized αS accumulates at tri-organelle contact sites linking mitochondria, endoplasmic reticulum, and endo/lysosomal compartments. At these interfaces, αS stabilizes generally dynamic contacts and constrains their remodeling, thereby rewiring organelle communication. These effects require the acidic αS C-terminus and are not recapitulated by intracellular αS overexpression. Proteomic profiling of αS-associated mitochondria identified a contact site-enriched but quality-control-deficient state. Functionally, spreading αS impairs neuron-astrocyte mitochondrial quality control (MQC) by reducing neuronal mitochondria transfer to astrocytes, while enhancing mitochondrial import. Our findings establish organelle contact sites as critical target of spreading αS, through which rewired organelle communication impairs MQC and neuron-astrocyte crosstalk. ### Competing Interest Statement The authors have declared no competing interest.

doi.org

😎 to have this out! --> stay tuned, this is a series about 📊#dataviz for #science 🧪

Nature Methods@natmethods.nature.com · 2mo ago

We are very excited to bring back our popular Points of View column, written by @helenajambor.bsky.social! Check out her first column in our July issue about the usage of color scales in scientific figures. www.nature.com/articles/s41...

🌠 BOOM! Bright meteor over Boston today — flash caught by NOAA GOES lightning sensor, boom recorded by Raspberry Shake! GOES shows stunning white-blue flash w/ purple halo over New England. Waveform from AM.R199D spikes at ~18:11 UTC. #Meteor #Boston

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

2 wks left to apply to join #BoBiAC2026! This course will teach you how to use Python to segment fluorescence images w/tools like @ilastik-team.bsky.social & CellposeSAM, & even how to measure cell features, neighborhood relationships, & colocalization. No coding experience needed! bobiac.github.io

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

The Farnung Lab is looking for postdoctoral researchers interested in understanding mechanisms at the intersection of chromatin, transcription, and replication. Find out more here: www.farnunglab.com

It is finally out there in published form. 🎉 #MicroSplit (with an 𝕊) #Microscopy 🔬 #AI 🤖 www.nature.com/articles/s41... And no paywall... so... enjoy the read! 💸 👋 This is where the post could end... but I will have to go on for a bit below... 😉 🧵

1/ Preprint alert 🚨🚨🚨 How do cells decide where an mRNA should end? And how is that decision coordinated with splicing and transcription while the RNA is still being made? Here's what first author @hopem105.bsky.social found 👇

(1/n) Super excited to share that our preprint is out today in @natsmb.nature.com with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: www.nature.com/articles/s41... See also MIT News news.mit.edu/2026/how-chr...

Anders Sejr Hansen@andersshansen.bsky.social · last yr.

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

Super excited to launch POCAxOMAP with @dschweppe.bsky.social and @oligopain.bsky.social and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further. www.biorxiv.org/content/10.6...

#microtubules in orange hot, #F-actin greyscale, Fibroblast, spinning disc. @marcoenriquez18.bsky.social @aibnatuq.bsky.social #fluorescenceFriday