We’ve recently been awarded a MIRA R35 and an R01 to study non-canonical roles and missense mutations of the Polycomb system in health, cancer, and neurodevelopmental disorders. We are seeking an animal tech with lab manager duties. Please share!
Lluis Morey
@lluismorey.bsky.social
In the Morey lab we study chromatin dynamics in neurodevelopmental disorders and cancer. Associate Professor at Sylvester Comprehensive Cancer Center and University of Miami. Science + Music moreylab.com
Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! www.cell.com/molecular-ce...
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
Borges, González-Blanco, Arigela, et al. report new missense mutations in the PRC1 genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional dissection of a deleterious variant...
cell.com
Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! www.cell.com/molecular-ce...
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
Borges, González-Blanco, Arigela, et al. report new missense mutations in the PRC1 genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional dissection of a deleterious variant...
cell.com
@lluismorey.bsky.social we are looking forward to your presentation at our #FusionEpigenetics meeting in Portugal this October! Please share this with your followers to let them know you will speaking, and to register & submit today to join us 🔗 bit.ly/4rC6B45
Exciting news! The lab is moving to Colorado at @cuanschutz.bsky.social 🎉 We’ll be recruiting at all levels—stay tuned!
H3K79me2/3 is sufficient to antagonise PRC1 www.nature.com/articles/s41...
DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology
Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...
nature.com
Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social
Our #FusionEpigenetics speaker line-up is 🔥 Join us in Portugal in October 2026 to hear directly from the scientists shaping the field. See who’s speaking and save your spot here! ➡️ bit.ly/4sq1khf
Our recent paper with @batllelab.bsky.social is now available in Cancer Discovery formatted PDF here aacrjournals.org/cancerdiscov... Enjoy Xmas reading 😅🎄🍾
A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer
AbstractInhibitors of the oncogene KRAS hold promise for treating metastatic colorectal cancer (mCRC). In this study, we show that a selective, covalent small-molecule inhibitor of the active (ON) con...
aacrjournals.org
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · 8mo agoBalanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇 www.sciencedirect.com/science/arti...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …
sciencedirect.com
It was a pleasure to write this News & Views article for the 4D Nucleome flagship article: www.nature.com/articles/d41... With great editorial support from @hollyasmith.bsky.social! Read the 4D Nucleome paper here: www.nature.com/articles/s41...
Systematic maps reveal how human chromosomes are organized
Our genomes are highly structured, which facilitates gene regulation. An ambitious project has catalogued the organization of DNA in the nuclei of human cells.
nature.com
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
nature.com
A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.
The Groth lab@grothlab.bsky.social · 2y ago🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS www.pnas.org/doi/10.1073/...
Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS
Recent work suggests that asymmetric segregation of preexisting and newly synthesized canonical histone 3.1 (H3.1), but not variant histone 3.3A (H...
pnas.org
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
biorxiv.org
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
biorxiv.org
Excited to see the latest from the Klose lab out this morning! Our brilliant PhD student Alan, now Dr Au, has dissected how SET1/MLL complexes shape H3K4me3 and shows they regulate transcription independently of their cat activity. He teamed up with Aleks to explore how. A few surprises!
Rob Klose@robklose.bsky.social · 8mo agoAn early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
Can't believe it's that time of year - registration already open for next year's Transcription & Chromatin meeting. Almost half the talks are selected from the abstracts, so register soon before it fills up. This is a very lively meeting, with plenty of time to discuss over dinner & at the bar
EMBL Events@events.embl.org · 8mo agoAre you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬 25 – 28 August 2026 Submit your abstract by 25 May: s.embl.org/trm26-01-bl #EMBLTranscript
Yesterday’s lab lunch felt really special. We took a moment to celebrate new papers, promotions, fresh faces in the lab—and, most of all, friendship. Grateful for this team. We’re stronger than ever.
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. www.biorxiv.org/content/10.1...
Bernie Sanders' office has put out a report this morning on Trump's NIH cuts: "Trump officials effectively cut $2.7 billion in [NIH] funding in the first three months of 2025 – including a 31 percent cut to cancer research through March, compared to the same timeframe last year."
Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky wgntv.com/evanston/nor...
Northwestern University to self-fund research despite Trump administration freeze
While university officials said they’ve still not received official word of such action, they acknowledged receiving about 100 stop-work orders from the federal government on roughly 100 fede…
wgntv.com
Seven New Cancer Grand Challenges Announced www.cancergrandchallenges.org/new-challenges With awards of up to £20m ($25m). Expressions of Interest are now open. @cancergrand.bsky.social #CancerGrandChallenges
Thank you to all the people who helped with making this work possible, inc. MSKCC Center for Epigenetic Research PJ Hamatd & Richard Koche @lluismorey.bsky.social . You all put a piece in this puzzle. Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 www.cell.com/cell/fulltex...
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...
cell.com
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
RNA polymerase II at histone genes predicts outcome in human cancer
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...
science.org
Fred Hutch@fredhutch.org · 2y agoResearchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...
New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n
bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 2y agoCHD3 regulates BMP signalling response during cranial neural crest cell specification https://www.biorxiv.org/content/10.1101/2025.02.14.638260v1
Killing cancer research, Trump and Musk are killing cancer research
Today, along with 2,000 other NIH employees, I had to clear out my office 😭 It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
