Congratulations to @gloryanne.bsky.social and our radiology, oncology and immunology teams for pioneering fine needle aspiration of HCC to tailor immunotherapy. We show that intratumoral neutrophils may predict CPI resistance: www.sciencedirect.com/science/arti...

Fine needle aspirates characterise the hepatocellular carcinoma immune niche to predict immune checkpoint inhibitor outcomes

Antitumour immunity involves a complex balance of immune effectors and regulators, many of which are adapted or compartmentalised within the local mic…

sciencedirect.com

It was such fun to gather Maini lab with @pallettlab.bsky.social @tcellvaccineucl.bsky.social @adas1.bsky.social and Alan Zhuang's labs for our Secret Santa lunch before the holidays. What a great bunch of smiles- proud they consider themselves the #ExtendedMainiFamily 😀

Pallett Lab UCL@pallettlab.bsky.social · 9mo ago

Get to turn up to work to see these faces every day #ExtendedMainiFamily

We're delighted to see immunologists once again recognised by the #NobelPrize! 🏆 Warm congratulations to the winners - their contributions have been vital in shaping our understanding of the immune system. More here: www.immunology.org/news/british...

Our paper is out! Check out this beautiful story where we uncovered that the costimulatory molecule ICOS is detrimental for PD-1+ CD8 T cells. Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.

The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

Understanding regulation of progenitor exhausted CD8+ T (Tpex) cell differentiation is important for immunotherapies. Humblin et al. report that sustained ICOS costimulation is detrimental to PD-1+CD8...

urldefense.proofpoint.com

Waggoner Lab@labwaggoner.bsky.social · last yr.

The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells @cp-immunity.bsky.social @kamphorstlab.bsky.social www.cell.com/immunity/ful...

Antigen-specific antibodies secreted by plasma cells are rapidly identified using microfluidics and fluorescence-activated cell sorting (FACS) go.nature.com/4dHLaHB rdcu.be/etg8W

Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells - Nature Biotechnology

Antigen-specific antibodies secreted by plasma cells are rapidly identified using microfluidics and fluorescence-activated cell sorting (FACS).

go.nature.com

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

Don’t miss this great scientific meeting and HBV family reunion

TestoniResearch@testoniresearch.bsky.social · last yr.

I am proud of organizing, together with Dr. Lena Allweiss, the #HBVmeeting2025! The place to be to connect with the #HBV scientific community! The Registration and Abstract Submission Portal are officially OPEN! 🔗 Visit www.hbvmeeting.org for details, key deadlines and access to the portals.

This will be an interesting project and great new lab-check out this post-doc position with our colleague Doug Fink @IIT UCL

Gabriele Pollara@gpollara.bsky.social · last yr.

Looking for a research assistant post in London? 🤔 Interested in how anti-cytokine auto-antibodies are associated with immune dysfunction and disease during ageing? 🎯 Then do consider applying for this exciting post 👇 #ImmunoSky #IDSky @uclmedsci.bsky.social www.ucl.ac.uk/work-at-ucl/...

We are very proud to bring you a highly requested new type of event this year 🙌: an ECR Careers Meeting 🤩 Join us Thurs. 13th March at the UCL IIT/Pears Building (Hampstead, London) 🚨Registration is FREE! Follow this link to register NOW! www.immunology.org/events/bsi-l... For more details👇

Nature research paper: Human-correlated genetic models identify precision therapy for liver cancer https://go.nature.com/41qNkbs

Human-correlated genetic models identify precision therapy for liver cancer - Nature

As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.

go.nature.com

#hiring #postdoc We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here: www.gla.ac.uk/explore/jobs...

Don’t forget to apply by 18th Feb for our 3 year Wellcome post-doc to join our great team working on HBV tissue immunity! www.linkedin.com/jobs/view/re...

Many of the extended 4th floor IIT family went out to celebrate Chinese New Year #YearOfTheSnake 🐍 - such a lovely evening 😊

Looking for an #immunology #postdoc? Then I *THOROUGHLY RECOMMEND* @mainilab.bsky.social Incredibly supportive PI & environment Cutting-edge science🧪 (dissecting hepatic #immunity in people w/ #hepatitisB & #cancer) Fab team & collabs Great institute APPLY NOW: www.linkedin.com/jobs/view/re...

Any post-docs interested in dissecting host-pathogen interactions in tissue- check out our advert on LinkedIn to join us @UCL IIT Pears Building! #immunosky

Open call for new research groups @pasteur.fr in Paris lots of immunology themes welcome #immunosky #IDsky #Scisky 🧪🥼🔬 get in touch if you have questions

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

A lipid made by tumour cells reprograms immune cells

Insights into how cancer cells become unresponsive to therapy.

nature.com

Why do some people, despite SARS-CoV-2 exposure, not develop an infection? An ultra-early interferon response blocks Covid www.thelancet.com/journals/ebi... adds to protection from pre-existing, cross-reactive T cells in some people

An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure

Our interferon-associated signature of early SARS-CoV-2 infection characterises a subgroup of exposed, uninfected contacts in three independent cohorts who may have successfully aborted infection prior to induction of adaptive immunity. The earlier transient upregulation of signature genes in PCR-negative compared to PCR-positive CHIM volunteers suggests that ultra-early interferon-associated innate immune responses correlate with, and may contribute to, protection against SARS-CoV-2 infection.

thelancet.com

An excellent PhD opportunity available in our team: long-range consequences of parasite infection, gut-lung communication and helminth-viral co-infection. Part of the EastBio training programme. Closing date 17th January. Please get in touch! www.findaphd.com/phds/project...

EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh on FindAPhD.com

PhD Project - EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh, listed on FindAPhD.com

findaphd.com

Thanks all for another great year's team work @UCL IIT and for all those fun Secret Santa pressies that kept us guessing! #immunosky

Pallett Lab UCL@pallettlab.bsky.social · 2y ago

Such a privilege to work with this fabulous group of people ❤️ Secret Santa, some lunch time fizz and plenty of laughs. Staying in, is the new going out 😊 #immunosky #scienceisfun

Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.

Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications

It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...

nature.com

More #evidence for the existence of #CD8 #Regulatory #Tcells www.nature.com/articles/s41... Check our previous paper also> #KIR+CD8+ #T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | Science www.science.org/doi/10.1126/...

Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma - Nature Immunology

Tumor-antigen-specific CD8+ T cells are generally thought to help fight against cancer, but here the authors identify a subpopulation of CD8+ T cells that are associated with a poor clinical outcome i...

nature.com

Engineering T cells with capability for a switch in specificity www.cell.com/immunity/ful... for better homing agents, to improve safety and efficacy vs cancer and other emerging T cell interventions

T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics

Abdelfattah et al. developed an engineering platform (T-Switch) for the creation, modification, and high-throughput profiling of T cell receptors (TCRs) to desired targets, particularly self-antigens....

cell.com

A vaccine platform targeting lung-resident memory CD4+ T-cells provides protection against heterosubtypic influenza infections in mice and ferrets www.nature.com/articles/s41...

Our top-rated #bioinformatics #training course 'Omic data analysis and visualisation using R' starts in less than 2 weeks (9 Dec) Perfect for those who want to gain new #DataAnalysis and #omics skills 🤩 Don't miss out! Book your place now 👉 bit.ly/4gXvxOF

Are neutrophils "good" or "bad"? Rana Herro reviews the current literature here: rdcu.be/d0Rt7

The diverse roles of neutrophils from protection to pathogenesis

Nature Immunology - In this Review, Herro and Grimes summarize the most recent key findings surrounding protective versus pathogenic functions of neutrophils, elaborating on phenotype-specific...

rdcu.be

Slowly but surely the migration from 🐦➡️🦋 is happening and those from our Institute are moving too ❤️ You can find those working at the UCL institute for immunity and transplantation (aka the 🍐🍐 building, if you know, you know) here: go.bsky.app/84owGLt #immunosky #academicsky 🧪

Great review of receptor ligand pairs mediating NK regulation of T cells

Waggoner Lab@labwaggoner.bsky.social · 2y ago

Germline NK cell receptors modulating the T cell response doi.org/10.3389/fimm...

🚨4yr PhD in Infection & Immunity🚨 Hosted at #UCL in the new Institute for Immunity & Transplantation (Pears Building, north London) 3x6wk rotations before selecting a lab for PhD Deadline: Jan 10 (Home tuition Fees+stipend) www.ucl.ac.uk/work-at-ucl/... #AcademicSky #PhDOpportunity #Immunosky

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk