Malte Rühlemann

@malte.ruehlemann.io

(he/his) human microbiome science and genetics first-gen PI in CRC1182 (@crc1182.bsky.social) PostDoc at IKMB / Poyet-Groussin Labs (@mmmicrobiomelab.bsky.social) Kiel, Germany

Great to see this important study published. For some time I've pointed to the preprint version when students ask about co-evolution between humans and their microbiota. "Limited codiversification of the gut microbiota within humans"

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Sawhney et al. followed 52 infants from birth to age 8, uncovering how gut microbiomes shift, stabilize, and evolve. A key finding: the emergence and timing of Bacteroides- and Prevotella-dominated enterotypes. 👶🧬 1/n

Gut microbiome evolution from infancy to 8 years of age - Nature Medicine

In a unique cohort of twins followed from birth to 8 years of age, shotgun sequencing of stool samples reveals that the transmission, persistence and evolutionary adaptation of bacterial strains are s...

doi.org

🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

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Not microbiome, but not less interesting: Cousins et al. introduce cobraa, a model revealing that all modern humans descend from two ancestral populations that split ~1.5 million years ago and later admixed ~300,000 years ago. This 80:20% ancestry mix challenges the idea of a panmictic origin 🌍🧬 1/n

Tian et al. designed a synthetic microbiota that suppresses C. difficile infection. Using machine learning, they built a 37-strain synthetic fecal transplant (sFMT1) that successfully inhibited C. difficile in vitro and in animal models. 🦠🛠️ 1/n

Lab mice (domesticated for >100y) have kept gut bacterial strains that codiversified w/ rodents for >25My. Here, authors show genetic drift occured in the lab, leading to loss of microb diversity+more deleterious mutations, impacting microbial fitness in lab vs wt mice www.nature.com/articles/s41...

Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice - Nature Communications

Here the authors show that lab mice have retained ancient gut bacterial symbionts that diversified in parallel with rodent species, but the genomes of these gut bugs have accumulated mutational burden...

nature.com

Coming from a GWAS-lab, my research interest for IBD and host-microbe interactions started here: In this classic paper from 2012, Jostins et al. analyzed 75k+ individuals, identifying new IBD-associated genetic loci, many of which reveal deep evolutionary and microbial connections 🦠📊 1/n

The gut microbiome isn’t just a collection of species—it’s a network of evolving subspecies. Doran et al. from the University of Chicago introduce the Spectral Tree, a new way to map these hidden evolutionary relationships. 🌱🧬 1/n

We're hiring a postdoc!🚨 Study human-associated microbial communities in health & disease. 🔬Requirements: - PhD in bioinformatics, microbiology, or related field - Expertise in omics - Strong publication record Apply now!🌟 jobs.vib.be/j/69697/post... @vibmicrobes.bsky.social

Postdoctoral position in bioinformatics of the human gut microbiome - VIB

About the Lab Thelab of JeroenRaes(VIB, KU Leuven) is home to a vibrant, dynamic and international group of researchers in the field of gut microbial ecology and its clinical applications

jobs.vib.be

Auschwitz was at the end of a long process. It did not start from gas chambers. This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder. Auschwitz took time.

A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.