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Marios Koutsakos

@marioskoutsakos.viralvaxlab.com

Influenza virologist in ViralVaxLab at TheDohertyInst https://www.viralvaxlab.com/ Influenza immunity, evolution & vaccines.

5 Posts716 Follower649 Folgt
Robert de Vries@rpdevrieslab.bsky.social ยท last yr.

Happy to be able to contribute to this very cool preprint Characterization of the glycoproteins of novel fish influenza B-like viruses #glycotime #lovevirology @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...

Characterization of the glycoproteins of novel fish influenza B-like viruses

Novel influenza-like virus sequences previously identified in fish and amphibians were found to cluster as a sister clade of influenza B viruses, but have thus far remained uncharacterized. We demonst...

biorxiv.org

Jennifer Juno@jenjuno.viralvaxlab.com ยท last yr.

Happy to report that Mitchell's paper on CD4 T cells and AIM assays is now available online at Science Advances! www.science.org/doi/10.1126/... Thanks to all our collaborators in @viralvaxlab.bsky.social and @thedohertyinst.bsky.social, including @assocprofashhaque.bsky.social lab

Deconvoluting TCR-dependent and -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay

CXCR4 down-regulation deconvolutes TCR-independent activation in the AIM assay.

science.org

Jennifer Juno@jenjuno.viralvaxlab.com ยท 2y ago

As a first #ImmunoSky post, Iโ€™m excited to share our latest pre-print, by the fantastic Mitchell Zheng! www.biorxiv.org/content/10.1... Our group is interested in virus-specific CD4 T cells, which means we often use in vitro stimulations (like the AIM assay) to find our cells of interest. ๐Ÿงต 1/9

Hensley Lab@scottehensley.bsky.social ยท last yr.

Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2 www.nature.com/articles/s41...

Immune history shapes human antibody responses to H5N1 influenza viruses - Nature Medicine

H5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 v...

nature.com

Erik Karlsson@eakarlsson.bsky.social ยท 2y ago

The Virology Unit at IPC has 3 positions open in #OneHealth: *Postdoc โ€“ Reconstructing Past Outbreaks *Postdoc โ€“ Environmental Surveillance *Clinical Manager These arenโ€™t just jobs. Theyโ€™re front-row seats to global health in action. Ready? tinyurl.com/57rvxcau #ViroSky #IDSky ๐Ÿฆ ๐Ÿ”ฌ๐Ÿงฌ๐Ÿฅผ๐Ÿงช

Institut Pasteur du Cambodge on LinkedIn: The Institut Pasteur du Cambodge (IPC) is looking for: -โ€ฆ

The Institut Pasteur du Cambodge (IPC) is looking for: - ๐๐จ๐ฌ๐ญ๐๐จ๐œ๐ญ๐จ๐ซ๐š๐ฅ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก๐ž๐ซ โ€“ ๐’๐ž๐ซ๐จ๐ฅ๐จ๐ ๐ฒ ๐š๐ญ ๐ญ๐ก๐ž ๐‡๐ฎ๐ฆ๐š๐ง-๐€๐ง๐ข๐ฆ๐š๐ฅโ€ฆ

tinyurl.com

The Journal of Immunology@jimmunol.bsky.social ยท last yr.

New research from @thedohertyinst.bsky.social suggests that receiving multiple doses of a vaccine in the same limb leads to faster antibody development, an important strategy for providing #immunity quickly during a pandemic or disease #outbreak. #ReadTheJI #immunology ow.ly/c28N50VeRGR

Modulation of germinal center and antibody dynamics via ipsilateral versus contralateral immunization against SARS-CoV-2

Abstract. Human clinical trials have reported immunological outcomes can differ between ipsilateral (same side) and contralateral (alternate sides) prime-b

ow.ly

Tom Peacock@peacockflu.bsky.social ยท 2y ago

Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!

Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.

In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...

biorxiv.org

Jennifer Juno@jenjuno.viralvaxlab.com ยท 2y ago

8/9 In short, we suggest in vitro stimulation activates ag-specific T cells, which secrete cytokines and activate Treg and Th17/22 cells. Without careful phenotyping, all of these cells can get picked up as AIM+, accounting for the Th17-like memory cells found in many virus-specific AIM datasets.

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Brian Wasik@brianrwasik.bsky.social ยท 2y ago

I have a few brief thoughts on this just released Science paper on the adaptation potential of bovine #H5N1 HA. Its very good work by very good group at Scripps! Think people need to be cautious in assessing the actualized risk out of this one study. #influenza www.science.org/doi/10.1126/...

A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors

In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...

science.org