#ImmunoSky #MicroSky

Dr Danika Hill@precisionvaxlab.bsky.social · 3mo ago

My lab is recruiting! To coincide with my relocation to WEHI in July, I’m recruiting for two Research Officer (Postdoc) positions. Both roles will be involved in advancing development of vaccines and therapeutics for Streptococcus pyogenes. Please spread the word! 📣 See 🧵for details 👇

My lab is recruiting! To coincide with my relocation to WEHI in July, I’m recruiting for two Research Officer (Postdoc) positions. Both roles will be involved in advancing development of vaccines and therapeutics for Streptococcus pyogenes. Please spread the word! 📣 See 🧵for details 👇

🚨 Our new paper is out today in Nature Chemical Biology: “Pan-specific antibodies to uncover bacterial pseudaminylation” doi.org/10.1038/s415... This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself. 1/6

Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...

doi.org

I’m really excited to begin this next chapter for my research at @wehi-research.bsky.social later this year. I also want to take this opportunity to sincerely thank all my colleagues from @monashuniversity.bsky.social for their support these past 5 years.

WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · 6mo ago

Say hello to our incoming lab heads! 👋 Excited to announce Dr Danika Hill, Dr Jacki Heraud-Farlow and Dr Sylvie Callegari will soon be establishing new labs at WEHI. More info: www.wehi.edu.au/news/excepti... bsky.app/profile/sylv... bsky.app/profile/jack... bsky.app/profile/prec...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

nature.com

🎓 PhD positions available @MonashUni Join our lab to explore how neurons and immune cells shape gut immunity! 🧬 Single-cell RNAseq 🔬 3D imaging 🧠 Neuro-immune interactions 👥 Great mentoring & collaborations Apply now 👉 tinyurl.com/Seilletlab

Congrats @linterman.bsky.social @smguillaume.bsky.social and team for this nice study about B cells fighting on the front lines (the 🫁)

Michelle Linterman@linterman.bsky.social · last yr.

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation. @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

New preprint alert 🚨 My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens. For paper: SSRN ssrn.com/abstract=519... biorxiv : doi: doi.org/10.1101/2025...

I’m so excited to be a chief investigator for this $10M Wellcome Trust grant, and for all the important things we’re going to learn about immunity against Strep A with researchers spanning three continents.

Josh Osowicki@joshosowicki.bsky.social · last yr.

A terrific postscript! Exciting @wellcometrust.bsky.social funded #StrepA work, with Ed Clarke, Hannah Frost, @precisionvaxlab.bsky.social, @njmoreland.bsky.social, @thushan-desilva.bsky.social, Penda Johm, Ya Jankey-Jagne, @drmichaelmarks.bsky.social, David Khoury, Andrew Steer.

Kicking off the new year searching for a postdoc to join our team @wehi-research.bsky.social Apply now and spread the word

Research Officer

Job Title Research Officer Job Description An excellent opportunity is available for a Research Officer to join the Groom Laboratory in the Immunology Division at Australia’s pre-eminent biomedical re...

wehi.wd3.myworkdayjobs.com

Really important #ImmunoSky findings from @jenjuno.viralvaxlab.com and co-authors about the pitfalls of using activation markers to detect antigen-specific T cells. Good news is they’ve found a marker combination that gets rid of bystander activated cells! Check out the preprint and 🧵 below 👀

Jennifer Juno@jenjuno.viralvaxlab.com · 2y ago

As a first #ImmunoSky post, I’m excited to share our latest pre-print, by the fantastic Mitchell Zheng! www.biorxiv.org/content/10.1... Our group is interested in virus-specific CD4 T cells, which means we often use in vitro stimulations (like the AIM assay) to find our cells of interest. 🧵 1/9

8/9 In short, we suggest in vitro stimulation activates ag-specific T cells, which secrete cytokines and activate Treg and Th17/22 cells. Without careful phenotyping, all of these cells can get picked up as AIM+, accounting for the Th17-like memory cells found in many virus-specific AIM datasets.

My n=1 experiment confirms that this scientifically tested recipe makes a delicious Cacio e Pepe, and the pre-print is surprisingly thorough!

Giacomo Bartolucci (he)@gbart.bsky.social · 2y ago

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce". Prepare to get cheesy, I'm glad to share the Cacio e paper preprint: arxiv.org/abs/2501.00536

Finally jumping into 🦋 - and what better way to do than highlighting this super thread. Wonderful to have been involved in this study with our Strep A friends across the Tasman

Dr Danika Hill@precisionvaxlab.bsky.social · 2y ago

🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵 rdcu.be/d2gBV Quick intro for the new followers: I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky

This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV

Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections

Nature Communications - Streptococcus pyogenes is a deadly bacteria without a vaccine. Here, researchers measured antibodies in serum and saliva from a strep throat human challenge trial. Baseline...

rdcu.be

🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵 rdcu.be/d2gBV Quick intro for the new followers: I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky

Hi everyone still plenty of room in the B cell starter pack please message if want to join the party! go.bsky.app/8avwjYw

This week in #ScienceImmunology: @jackiheraudfarlow.bsky.social , Carl Walkley, & colleagues used a genome-wide #CRISPRscreen to determine that a GGNBP2– CNOT10/11 complex is required for the accumulation of unedited #immunogenic self- #dsRNA & its sensing by #MDA5!

GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing

GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.

science.org

Today I had a collaborator say “I never share my findings with anyone before they’re published. I’ve been burnt before”. It’s got me wondering how widespread ‘getting burnt’ is in science. 🤔 #ImmunoSky I’m keen to hear horror stories and what impact it had on your approach to science!!

I spent this last week at Biomolecular Horizons conference in Melbourne and fell in love with the “Stories and Structures” art exhibit on display from Microscopy Australia. (1/2) It’s worth a look! micro.org.au/stories-stru...

My X feed is mostly gun violence and pro-Trump nonsense. Time for a radical change! Hoping to find the twitter community I’ve lost. I’m interested in all things immunology, but particularly adaptive immune responses to vaccines and infectious disease. Bring on bluer skies!