Just Published ! #Clathrin superstar! onlinelibrary.wiley.com/doi/10.1111/...

From Pits to Plaques: Electron Microscopy Reveals Clathrin Structural Plasticity in Trafficking, Sorting and Adhesion

Clathrin plaques (magenta) form large, flat membrane-associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin-coated pits (yellow). These....

onlinelibrary.wiley.com

Endosomal membrane state governs trafficking and cell migration under TFEB control www.biorxiv.org/content/10.6...

Endosomal membrane state governs trafficking and cell migration under TFEB control

Transcription Factor EB (TFEB) regulates the biogenesis of lysosomes, which are acidic organelles of the endosomal network. While its role in cellular clearance is well established, the pleiotropic fu...

biorxiv.org

Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear mechanobiology: www.tandfonline.com/doi/full/10....

Nuclear mechanobiology: a brief history and five unresolved questions

Published in Nucleus (Vol. 17, No. 1, 2026)

tandfonline.com

🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical? Thrilled to share our new paper in @NatureCellBio : Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇 www.nature.com/articles/s41... 1/11

Elevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell Biology

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

nature.com

How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

Everyone says AI will accelerate science. I don't think it will -- at least not in biology, and at least not soon. New post where I explain why, and how the productivity paradox can be resolved: blekhman.substack.com/p/why-ai-wil...

Why AI will not speed up science (yet)

You can see AI everywhere except in the productivity statistics

blekhman.substack.com

1/5 🎉 Finally, the results of my main postdoctoral project are out in @natcomms.nature.com! Adhesion-derived condensates control component availability to regulate adhesion dynamics bit.ly/4y9E8Xr Also excited to see the paper highlighted in Nat Comms Editors’ Highlights 🥳 bit.ly/44n4O9i

Excited to share our new paper, now published in Nature Cell Biology! 🎉 We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces? www.nature.com/articles/s41556-026-01981-1

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

nature.com

This is huge! Triple Negative Breast Cancers (TNBCs) are aggressive & disproportionately strike younger women. Historically, TNBCs have limited treatment options. Trodelvy, which targets Trop-2 is now approved in the US for first line treatment of metastatic TNBC. 🧪 www.gilead.com/news/news-de...

My first time seeing actin geodesic domes, and I have to say: they are *gorgeous*. Nature really knows how to get organized! Little is known about their function, so any input is very welcome! #FluorescenceFriday #Actin

Excited to share that our work on ‘How the gut gets patterned during regeneration’ is out now cell.com/cell/fulltext/S0092-8674(26)00696-3 Thanks a lot to @priscaliberali.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social and all co-authors! 🧵

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

www.nature.com/articles/s41...

Boundary geometry controls a topological defect transition that determines lumen nucleation in embryonic development - Nature Materials

The geometry of confining boundaries is shown to control three-dimensional topological defect configurations that precede formation of the central lumen in the developing mouse embryo, a key process i...

nature.com

Delighted to share our latest preprint "NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations" www.biorxiv.org/content/10.6... Code and App: github.com/CellMigratio...

Galvanin (TMEM154) is an electric-field sensor for directed cell migration: Cell www.cell.com/cell/fulltex...

Galvanin (TMEM154) is an electric-field sensor for directed cell migration

Galvanin is an electric-field sensor that links electrical cues to directed migration in rapidly moving cells.

cell.com

rupress.org/jcb/article/...

Procollagen 1 assembles into phase-separated condensates in the endoplasmic reticulum

In contrast to prevailing dogma, we report that procollagen 1 assembles into a liquid condensate within cells, resolving the long-standing problem of how c

rupress.org

Starting to write up the first mechanistic paper from my lab about regulation of endosomal PI(3)P. We see retromer tubules (Vps35) budding from PI(3)P positive sorting endosomes with Actin at the neck. When PI(3)P homeostasis is perturbed this organisation breaks down and cells cant recycle cargo.

Alright, I am pausing my social media break to share with you the final review of my PhD erra (times fly by 🥲). Featuring 2 of my favorite science fields: #RNAbiology and #celladhesion 😍. Also a fantastic collab with one of my top #women_in_sci role models: Stavroula Mili 💙

Paying peer reviewers works. Expanded Fast & Fair experiment @biologyopen.bsky.social: • 5.5 vs 37.7 working days to decision with reviews • ~3 vs ~9 reviewer invitations per manuscript • no reduction in editor-assessed review quality • similar acceptance rates www.biorxiv.org/content/10.6...

Hämälistö, @fadelvalle.bsky.social, Yuseff, and @mattilalab.bsky.social review how #BCells have adopted specialized ways to use endolysosomal vesicles to promote adaptive immune responses. rupress.org/jcb/article/... 📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...

How to determine the proteome of cellular compartments? We established a method to do just that, published n @eLife.bsky.social: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLif...

NEW PREPRINT ALERT (shameless plug: www.biorxiv.org/content/10.6...) We’ve all been there: Sitting in a cell biology talk when suddenly— cytoskeleton fireworks EB1-GFP comets streaking across the screen. Tiny glowing microtubules everywhere. Absolute cinema.

For this #FluorescenceFriday, some endosomes imaged with MI-SIM. Green: Rab21, Magenta: F-actin, Cyan: EPLINalpha.

A membrane-permeable small molecule biosensor accesses intractable cells and animals without genetic manipulation www.biorxiv.org/content/10.6...

i visited DSHB @dshb-antibodies.bsky.social 2 years ago, incredible how such a critical community scientific resource is run so efficiently, economically and humbly. they maintain 1000s of mAbs at cost, and are fully self-supported from just a couple lab rooms!

Mark Peifer (He, him)@peiferlabunc.bsky.social · 5mo ago

By the way, @dshb-antibodies.bsky.social is a non-profit that sells quality antibodies to many proteins at exceptionally reasonable prices, without AI generated faux-validation images. Check them out. dshb.biology.uiowa.edu

🚨 New preprint from the Feigin Lab! 🚨 www.biorxiv.org/content/10.6... Opioids have profound effects on the pancreatic cancer microenvironment! An FDA-approved opioid antagonist that doesn't cross the blood brain barrier decreases tumor aggressiveness in a mouse model of pancreatic cancer!

Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis rupress.org/jcb/article/...

Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis

Lysosomal cargo sorting from the early endosomes should involve mechanisms that prevent their recycling to the plasma membrane. Here, Chouhan P and Phogat

rupress.org

Beautiful work published by my new Lab at @nature.com today! @dorie00.bsky.social et al. created MouseMapper, an AI-powered tool that identifies & maps cells/tissues throughout the whole mouse body. We can now use this for different diseases, such as #LongCovid. This is AI being used the right way!

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...