Biological aging and generational shifts in early-onset cancer risk - Nature Medicine

Analyses of population cohorts found that young adults exhibited earlier systemic and organ-specific aging, which was associated with increased risk of early-onset cancer compared with older adults born decades earlier.

dlvr.it

The long-lived immune system of centenarians

Nature Reviews Immunology, Published online: 23 April 2026; doi:10.1038/s41577-026-01291-5What is unique about the immune system of people who live to extreme old age? Here the authors describe that centenarians may achieve such longevity through several mechanisms, including limiting the pathological effects of inflammageing and immunosenescence, preservation of immune surveillance, sustained gut microbial diversity and maintenance of intestinal barrier integrity.

dlvr.it

Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis

Objective Pain is the hallmark symptom of osteoarthritis (OA), and its biologic drivers remain poorly understood. Although the role of innate immunity in OA has been extensively studied, the involve...

acrjournals.onlinelibrary.wiley.com

Interpretable inflammation landscape of circulating immune cells - Nature Medicine

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

nature.com

COPA syndrome spans multiple organs but is defined by STING in the lung

Nature Reviews Rheumatology, Published online: 07 January 2026; doi:10.1038/s41584-025-01350-6A large European cohort clarifies COPA syndrome as a multi-organ interferonopathy defined by STING-driven interstitial lung disease (ILD). These findings refine diagnosis and treatment and establish COPA syndrome as a model for systemic autoimmune rheumatic disease-associated ILD.

dlvr.it

Remembering Atul Butte

This Medical News article is in remembrance of Atul Butte, MD, PhD, a pioneer in using data science to improve health.

jamanetwork.com

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

science.org

T-cell receptor repertoire and HLA in osteoarthritis: A systematic literature review

The aim of this systematic literature review was to provide a comprehensive overview of T-Cell Receptor (TCR) mediated immunity research in osteoarthritis (OA).

oarsijournal.com

UCSF Bioinformatics Pioneer Atul Butte Dies at 55

Atul Butte, who championed the use of big data in science and health care and inspired a generation of trainees at UC San Francisco and beyond to pursue the fields he pioneered — translational and cli...

tiny.ucsf.edu

Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases - Nature Reviews Rheumatology

In this Review article, the potential of cytometry- and single-cell RNA sequencing-based immune profiling for aiding the diagnosis and personalized treatment of rheumatic diseases is discussed.

nature.com

Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3

Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.

science.org

Molecular endotypes and theratypes in osteoarthritis: transforming a concept into reality with deep learning and multiomics

Osteoarthritis (OA) is now understood as a heterogeneous disease in many respects, including its clinical presentation, underlying pathophysiological mechanisms, and response to treatments. Distinct p...

ard.eular.org

UCSF Scientist Receives High Honor for Exceptional Career

Researcher and campus leader Atul Butte, MD, PhD, has been recognized for his outstanding career in the computational and health sciences with induction into the American Academy of Arts and Sciences,...

tiny.ucsf.edu

Serum intestinal permeability biomarkers are associated with erosive hand osteoarthritis and radiographic severity: results from the DIGICOD cohort

To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA).

oarsijournal.com

Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies

Nature Reviews Rheumatology, Published online: 07 February 2025; doi:10.1038/s41584-025-01218-9Garrido-Mesa and Brown review findings from TCR profiling studies in rheumatic diseases and discuss how improved study design might help elicit information…

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